Opportunity Information: Apply for RFA NR 12 002
Apply for RFA NR 12 002
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Application of Genomic Advances to Wound Repair (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research.
- This funding opportunity was created on Nov 18, 2011 and posted on Nov 18, 2011.
- Applicants must submit their applications by Jan 23, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: For profit organizations other than small businesses Native American tribal governments (Federally recognized) Independent school districts Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Public and State controlled institutions of higher education County governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Special district governments Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments State governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The National Institute of Nursing Research (NINR), part of the National Institutes of Health (NIH), offered this R01 grant opportunity to push forward research on why chronic wounds start and why they fail to heal, using modern genomic science as the main lens. In this announcement, a chronic wound is defined as a wound that has not moved through a normal repair process within three months. The overall goal is twofold: first, to deepen scientific understanding of the genomic mechanisms involved in the development and repair of these difficult-to-heal wounds; and second, to develop and test interventions that are explicitly informed by genomics, with the aim of preventing chronic wounds or speeding up healing once they occur. The underlying expectation is that stronger genomic knowledge will help clinicians and researchers identify which individuals are most at risk for chronic wounds and will support the longer-term shift toward more customized therapies tailored to a persons genomic profile.
The research focus is centered on applying advances in genomics to wound repair, which can include studying how genes are turned on or off during different phases of healing, how genetic variation may affect inflammation, tissue regeneration, vascular function, infection susceptibility, or collagen and extracellular matrix remodeling, and how these biological differences might explain why some wounds stall. The opportunity also emphasizes translation, meaning it is not limited to basic discovery; it encourages building on genomic insights to design and test interventions that use genomic information in a meaningful way. In practical terms, this could involve identifying genomic markers associated with poor healing and then using that information to guide prevention strategies, risk stratification, or targeted treatments. The announcement frames the payoff as improved prediction of chronic wound risk and stronger evidence for individualized or precision-style wound care approaches.
Administratively, this was a discretionary grant opportunity using the NIH R01 mechanism (Funding Opportunity Number RFA-NR-12-002, titled Application of Genomic Advances to Wound Repair (R01)). It was posted on November 18, 2011, with an application closing date of January 23, 2012, and an archive date of February 23, 2012. The estimated total funding available was $2,000,000, and the listed award ceiling was $300,000. There was no cost sharing or matching requirement. The program falls under the Nursing Research CFDA listing (93.361), reflecting NINRs mission and the grants emphasis on research that can ultimately strengthen nursing-relevant science and care outcomes for patients dealing with chronic wounds.
Eligibility was broad across many U.S.-based organization types. Eligible applicants included public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, small businesses, and a wide range of government entities such as state governments, county governments, and city or township governments, as well as special district governments and independent school districts. The opportunity also explicitly included various mission-focused institutions and community-linked organizations, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and certain eligible federal agencies. At the same time, the announcement clearly excluded non-U.S. entities and foreign institutions, non-U.S. components of U.S. organizations, and foreign components as defined by NIH policy.
For applicants or reviewers, the core idea behind this funding opportunity is that chronic wounds are a major, persistent clinical problem and that genomics offers a path to explain individual differences in healing and to design smarter interventions. NINR positioned this program as a way to build the evidence base for identifying high-risk individuals earlier and for developing more tailored therapeutics and interventions grounded in each persons biology, rather than relying solely on one-size-fits-all approaches to wound prevention and treatment. For additional details, the full announcement was made available through the NIH grants website at the link provided in the source, and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is this grant opportunity?
This is a National Institutes of Health (NIH) R01 funding opportunity from the National Institute of Nursing Research (NINR) titled Application of Genomic Advances to Wound Repair (R01), Funding Opportunity Number RFA-NR-12-002. It supports research that uses modern genomic science to better understand chronic wounds and to develop genomics-informed interventions.
Which NIH institute offered this program?
The program was offered by the National Institute of Nursing Research (NINR), which is part of the NIH.
What problem area is the program trying to address?
The program targets chronic wounds as a major, persistent clinical problem, focusing on why these wounds begin and why they fail to heal normally.
How does this announcement define a chronic wound?
In this announcement, a chronic wound is defined as a wound that has not moved through a normal repair process within three months.
What are the main goals of the funding opportunity?
The goals are twofold: (1) to deepen scientific understanding of the genomic mechanisms involved in the development and repair of chronic wounds, and (2) to develop and test interventions that are explicitly informed by genomics to prevent chronic wounds or speed healing once they occur.
What kind of science is emphasized in this opportunity?
The emphasis is on applying advances in genomics to wound repair, including understanding how genomic factors may shape different phases of healing and why healing can stall in some individuals.
Does the opportunity focus only on basic research, or does it include intervention work?
It includes translation and is not limited to basic discovery. The announcement encourages building on genomic insights to design and test interventions that use genomic information in a meaningful way.
What are examples of research topics that fit the program focus?
Examples described in the announcement include studying: how genes are turned on or off across healing phases; how genetic variation may influence inflammation, tissue regeneration, vascular function, infection susceptibility, or collagen and extracellular matrix remodeling; and how these differences might explain why some wounds stall.
How is genomics expected to improve chronic wound care?
The underlying expectation is that stronger genomic knowledge will help identify which individuals are most at risk for chronic wounds and will support a longer-term shift toward customized therapies tailored to a person’s genomic profile (precision-style approaches).
What does the announcement mean by "translation" in this context?
Translation here means moving from genomic discovery toward practical use, such as identifying genomic markers associated with poor healing and then using that information to guide prevention strategies, risk stratification, or targeted treatments.
What funding mechanism was used?
The opportunity used the NIH R01 research project grant mechanism.
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-NR-12-002.
When was the opportunity posted and when did it close?
It was posted on November 18, 2011. The application closing date was January 23, 2012.
Is this funding opportunity still active?
No. The announcement lists an archive date of February 23, 2012, indicating it is archived rather than currently open.
How much total funding was expected to be available?
The estimated total funding available was $2,000,000.
What was the award ceiling?
The listed award ceiling was $300,000.
Was cost sharing or matching required?
No. The announcement states there was no cost sharing or matching requirement.
What CFDA program listing applies to this opportunity?
The opportunity falls under the Nursing Research CFDA listing 93.361.
Who was eligible to apply?
Eligibility was broad across many U.S.-based organization types, including: public and private institutions of higher education; nonprofit organizations (with or without 501(c)(3) status); for-profit organizations other than small businesses; small businesses; and government entities such as state, county, and city or township governments, as well as special district governments and independent school districts.
Were community-linked or mission-focused institutions included?
Yes. The opportunity explicitly included organizations such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, and certain eligible federal agencies.
Were foreign organizations eligible to apply?
No. The announcement excluded non-U.S. entities and foreign institutions, as well as non-U.S. components of U.S. organizations and other foreign components as defined by NIH policy.
What is the broader clinical and research rationale behind this program?
NINR framed the program around the idea that chronic wounds remain difficult to manage and that genomics offers a path to explain individual differences in healing. The intended payoff is improved prediction of chronic wound risk and stronger evidence to support individualized, precision-style wound prevention and treatment approaches.
Where were applicants directed for the full official announcement?
The full announcement was made available through the NIH grants website (at the link provided in the original source materials).
Who was listed as the contact for technical access issues?
Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
Browse more opportunities from the same category: Education Health
Next opportunity: Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01)
Previous opportunity: Application of Genomic Advances to Wound Repair (R21)
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| Early Stage Innovative Technology Development for Cancer Research (R21) Apply for RFA CA 12 002 Funding Number: RFA CA 12 002 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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