Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01) | Apply Online

Opportunity Summary:

The Behavioral Interventions to Address Multiple Chronic Health Conditions in Primary Care (R01) opportunity (Funding Opportunity Number PA-12-024) is a National Institutes of Health (NIH) discretionary grant announcement designed to support research project grants (R01s) focused on improving outcomes for patients who are dealing with multiple chronic conditions at the same time. The central idea is to fund primary care-based research that tackles the real-world complexity of comorbidity, where patients often have overlapping physical and behavioral health challenges that cannot be effectively addressed through separate, condition-by-condition programs. Instead of stacking multiple standalone interventions on a single patient, applicants are expected to propose a unified behavioral intervention strategy grounded in a common conceptual model, aiming to modify key behaviors and ultimately improve patient-level health outcomes.

A defining feature of this FOA is its focus on people with three or more chronic health conditions, reflecting a population that is common in primary care and often at high risk for poor health outcomes, fragmented care, and increased healthcare utilization. The interventions supported under this announcement should take a multi-disease care management approach and be designed for implementation in primary care settings, where coordination and feasibility matter. The expectation is that the proposed work will demonstrate strong potential for meaningful impact, not just small improvements in isolated metrics, and that it will be structured in a way that accounts for the complexity of managing several conditions simultaneously.

The FOA also makes clear what it means by a "common approach." Rather than offering a separate intervention for smoking cessation, another for diabetes self-management, and a third for depression, the project should use a single overarching framework to drive behavior change across conditions. This could involve shared mechanisms like improving self-regulation, enhancing motivation and adherence, strengthening problem-solving skills, building routines, addressing stress and coping, or leveraging care team supports in a way that benefits multiple conditions at once. The chronic diseases and conditions relevant to this announcement are broad and include, but are not limited to, mental health disorders such as depression, diabetes, smoking, obesity, chronic pain, alcohol and substance abuse and dependence, chronic obstructive pulmonary disorder (COPD), cancer, and hypertension. The breadth of examples signals that NIH is open to a variety of comorbidity combinations, as long as the proposed intervention is cohesive and targets common behavioral pathways.

In terms of administrative details, this is an NIH Research Project Grant (R01) funding mechanism, categorized under health and education-related funding activities. It is explicitly noted that there is no cost sharing or matching requirement, which means applicants are not required to provide matching funds as a condition of eligibility. The program was posted and created on November 18, 2011, with an original and current closing date of January 7, 2014, and an archive date of February 7, 2014, indicating the opportunity is no longer active but remains useful as a reference for how NIH frames this research area.

Eligibility is broad across many types of U.S.-based organizations. Eligible applicants include small businesses, private and public institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (other than small businesses), and various units of government such as state governments, county governments, city or township governments, special district governments, and independent school districts. The FOA also highlights additional eligible entities including Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), tribally controlled colleges and universities (TCCUs), regional organizations, U.S. territories or possessions, and certain tribal organizations and tribal governments (with distinctions noted between federally recognized and other tribal entities). At the same time, the announcement is explicit that non-U.S. entities are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components are not allowed under NIH policy as referenced in the NIH Grants Policy Statement.

The FOA is associated with multiple CFDA program areas, reflecting the cross-cutting nature of multi-condition behavioral intervention research. These include Mental Health Research Grants (93.242), Alcohol Research Programs (93.273), Drug Abuse and Addiction Research Programs (93.279), Nursing Research (93.361), Cancer Control (93.399), Cardiovascular Diseases Research (93.837), and Aging Research (93.866). That mix reinforces the intent to draw multidisciplinary proposals that may span behavioral health, chronic disease management, and primary care delivery, especially in populations where aging and comorbidity overlap.

For applicants and researchers looking to understand the full scope of expectations, the archived NIH program page is provided as the official reference: http://grants.nih.gov/grants/guide/pa-files/PA-12-024.html. For access or technical issues related to the electronic announcement, the contact listed is the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.

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