Application of Metabolomics for Translational and Biological Research (R01) | Apply Online

Opportunity Summary:

The NIH funding opportunity titled "Application of Metabolomics for Translational and Biological Research (R01)" (Funding Opportunity Number PA-07-301) supports research projects that use metabolomics to answer practical, health-focused questions in humans and disease-relevant biology. Metabolomics refers to measuring many small molecules (metabolites) at once in samples such as cells, tissues, or body fluids, with the goal of capturing a real-time snapshot of biochemical activity. The core intent of this announcement is to push metabolomic technologies beyond method development alone and into translational research that can directly improve how diseases are detected and understood in real-world settings. Projects are expected to show how metabolomics can contribute to better disease detection and diagnosis, improved risk assessment, stronger prognostic tools, and more accurate prediction of how patients will respond to therapies.

This announcement uses the NIH Research Project Grant (R01) mechanism, which is designed for full-scale, hypothesis-driven or well-justified research programs with clear aims, strong preliminary rationale, and a plan that can deliver meaningful outcomes. It also runs alongside a companion announcement with the same scientific scope that uses the R21 mechanism (PA-07-302), which is aimed more at pilot or exploratory work. In practice, that pairing signals that NIH is trying to support both early-stage feasibility studies (through R21) and more mature, comprehensive projects (through R01) that are ready to produce translationally relevant results.

The opportunity is sponsored by multiple NIH institutes and spans a wide range of health areas, reflecting how broadly metabolomics can be applied across disease biology and clinical research. The associated CFDA program areas include oral diseases and disorders, drug abuse and addiction research, multiple cancer research categories (cause and prevention, detection and diagnosis, treatment, and biology), cardiovascular diseases, blood diseases and resources, diabetes/digestive/kidney diseases, and aging research. This breadth indicates that NIH is interested in metabolomics as a cross-cutting platform that can uncover biomarkers, illuminate mechanisms, and improve clinical decision-making across many conditions rather than being limited to a single disease field.

In terms of eligibility, the announcement is open to a broad set of applicant organizations, including public and state-controlled institutions of higher education, private institutions of higher education, for-profit organizations (other than small businesses), and small businesses. Foreign institutions are also eligible, which is notable because not all NIH opportunities allow foreign applicants. There is no cost sharing or matching requirement, so applicants are not required to provide non-federal funds as a condition of the award. Like most NIH grants, funding is not guaranteed; awards depend on the availability of funds and whether enough high-quality applications are received and judged meritorious through peer review.

Administratively, the opportunity was posted on January 17, 2007, and it used multiple receipt dates rather than a single deadline, meaning applications could be submitted on recurring standard NIH due dates specified in the full announcement. The archived date is February 2, 2010, which indicates the specific announcement is no longer active, but it still serves as a clear example of NIH priorities around applying metabolomics to translational questions. For the authoritative details such as application instructions, due dates, review criteria emphases, and institute-specific interests, applicants were directed to the full FOA text and to NIH Office of Extramural Research support contacts for access or linking issues.

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Previous opportunity: Hypersensitivity Pneumonitis Early Identification and Mechanisms of Disease (R01)

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