Opportunity Information: Apply for RFA HS 10 006
Apply for RFA HS 10 006
- The Agency for Health Care Research and Quality in the health recovery act sector is offering a public funding opportunity titled "ARRA AHRQ Recovery Act 2009 Limited Competition Electronic Data Methods (EDM) Forum for Comparative Effectiveness Research (U13)" and is now available to receive applicants.
- This funding opportunity was created on Dec 8, 2009 and posted on Dec 8, 2009.
- Applicants must submit their applications by Jan 20, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $4,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Indian/Native American Tribal Governments (Other than Federally Recognized) Units of local government Under the most recently enacted reauthorization legislation, AHRQ is authorized to enter into cooperative agreements with for profit organizations, as well as with public and not for profit entities. Thus for the purpose of this FOA, AHRQ will make grants only to non profit organizations. For profit organizations may participate in projects as members of consortia or as subcontractors only. Foreign institutions may participate in projects as members of consortia or as subcontractors only. Applications submitted by for profit organizations and foreign institutions will be returned without review. Organizations described in section 501(c) 4 of the Internal Revenue Code that engage in lobbying are not eligible. Any individual(s) with the skills, knowledge, and resources necessary to carry out the proposed research as the PD/PI is invited to work with his/her organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for AHRQ support. This project requires a minimum PD/PI effort of 10 percent.
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Opportunity Summary:
The ARRA AHRQ Recovery Act 2009 Limited Competition Electronic Data Methods (EDM) Forum for Comparative Effectiveness Research (U13) was a 2009 funding opportunity from the Agency for Healthcare Research and Quality (AHRQ) designed to support a large, structured forum focused on improving how researchers use electronic clinical data for comparative effectiveness research (CER). Funded through the American Recovery and Reinvestment Act of 2009 (ARRA), this cooperative agreement aimed to strengthen the practical infrastructure and methodological toolkit needed to collect and analyze prospective data drawn from electronic clinical databases, especially for studies comparing tests, treatments, and real-world clinical interventions.
At the center of the announcement was the creation and operation of an Electronic Data Methods (EDM) forum that would bring together a targeted set of stakeholders. AHRQ specifically envisioned convening investigators running PROSPECT studies (Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies), along with experts in clinical registries, distributed research network methods, health information technology, and outcomes research. The forum was also intended to include practicing clinicians and representatives of relevant organizations, plus additional stakeholders when needed, so the discussion would reflect real operational constraints and the realities of care delivery settings, not just academic theory.
The main deliverable was not a traditional research project, but an organized series of meetings and workshops that would systematically surface the barriers to doing high-quality CER using electronic data and then push toward actionable solutions. The FOA highlighted a broad range of challenge areas the forum should address, including scientific issues (such as validity of measures, confounding, and comparability across sites), technical issues (data standards, interoperability, extraction and transformation, data quality, and linkage), and organizational and clinical workflow issues (how data are captured in routine care and what that means for research use). It also emphasized legal and ethical barriers, with explicit attention to HIPAA compliance and the complexities of privacy, consent, governance, and data sharing across institutions. Beyond identifying problems, the EDM forum was expected to propose realistic solutions where feasible, and when solutions were not immediately available, to outline a concrete research agenda or structured discussions that could move the field toward resolution.
Administratively, this was a discretionary funding opportunity using a cooperative agreement mechanism (U13), which typically means AHRQ anticipated substantial program involvement and collaboration rather than a hands-off grant. There was no cost sharing or matching requirement. The opportunity was posted on December 8, 2009, and closed on January 20, 2010, with an archive date of February 20, 2010. The estimated total funding amount listed was $4,000,000, reflecting the Recovery Act investment in accelerating health research capabilities and near-term impact.
Eligibility was focused on non-profit organizations, even though AHRQ generally has authority to enter cooperative agreements with for-profit entities. Under this FOA, applications from for-profit organizations and foreign institutions were not eligible as lead applicants and would be returned without review, though those entities could participate as consortium members or subcontractors. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, federally recognized tribal governments, other tribal organizations, units of local government, and eligible federal agencies. The FOA also excluded 501(c)(4) organizations that engage in lobbying. The principal investigator requirement included a minimum effort commitment of 10 percent, and AHRQ reiterated its standing encouragement for applications involving individuals from underrepresented racial and ethnic groups and individuals with disabilities.
In practical terms, this grant opportunity was about building shared methods and consensus across the CER community at a moment when electronic health records, registries, and distributed data networks were expanding quickly, but the field still faced major gaps in standardization, governance, and trustworthy analytic approaches. By funding a dedicated EDM forum, AHRQ sought to accelerate progress by convening the right mix of experts and stakeholders to map the toughest obstacles and define workable paths forward for using electronic clinical data in comparative effectiveness research.
Frequently Asked Questions (FAQs)
What is the ARRA AHRQ Recovery Act 2009 Limited Competition Electronic Data Methods (EDM) Forum for Comparative Effectiveness Research (U13)?
It was a 2009 funding opportunity from the Agency for Healthcare Research and Quality (AHRQ), supported by the American Recovery and Reinvestment Act of 2009 (ARRA). The award used a cooperative agreement mechanism (U13) to support the creation and operation of a large, structured Electronic Data Methods (EDM) forum focused on improving how electronic clinical data can be used for comparative effectiveness research (CER).
What was the overall purpose of this funding opportunity?
The purpose was to strengthen the practical infrastructure and methodological toolkit needed to collect and analyze prospective data drawn from electronic clinical databases, especially for studies that compare tests, treatments, and real-world clinical interventions.
What type of award mechanism was used (and what does it imply)?
The opportunity used a cooperative agreement (U13). This typically means AHRQ expected substantial program involvement and collaboration with the awardee, rather than a fully hands-off relationship.
Was this a traditional research grant?
No. The main deliverable was not a traditional research project. It centered on organizing and running meetings and workshops that would identify barriers to high-quality CER using electronic data and push toward actionable solutions or a concrete research agenda when solutions were not immediately available.
What was the primary deliverable expected from the award?
The primary deliverable was an organized series of meetings and workshops (an EDM forum) designed to systematically surface key barriers in conducting CER with electronic clinical data and to propose realistic solutions where feasible.
Who did AHRQ expect to participate in the EDM forum?
AHRQ envisioned a targeted set of stakeholders, including investigators running PROSPECT studies (Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies), experts in clinical registries, distributed research network methods, health information technology, and outcomes research. The forum was also intended to include practicing clinicians and representatives of relevant organizations, with additional stakeholders included as needed.
Why were practicing clinicians and organizations included in the forum design?
The forum was intended to reflect real operational constraints and the realities of care delivery settings, not just academic theory. Including clinicians and organizational representatives helped ensure discussions addressed how data are actually captured in routine care and what that means for research use.
What kinds of barriers and challenge areas was the forum expected to address?
The forum was expected to address scientific, technical, organizational, clinical workflow, and legal/ethical barriers to conducting CER using electronic data.
What scientific issues were highlighted as areas for discussion?
Highlighted scientific issues included validity of measures, confounding, and comparability across sites.
What technical issues were highlighted as areas for discussion?
Highlighted technical issues included data standards, interoperability, extraction and transformation, data quality, and linkage.
What organizational and clinical workflow issues were highlighted?
The forum was expected to address how data are captured in routine care and how clinical workflows affect the research use of those data.
What legal and ethical topics were explicitly emphasized?
The opportunity emphasized legal and ethical barriers, explicitly including HIPAA compliance and the complexities of privacy, consent, governance, and data sharing across institutions.
Was the forum expected only to identify problems, or also to propose solutions?
It was expected to do both. The EDM forum was to identify barriers and propose realistic solutions where feasible. When solutions were not immediately available, it was expected to outline a concrete research agenda or structured discussions to move toward resolution.
What does CER mean in the context of this opportunity?
Comparative effectiveness research (CER) in this context focused on using electronic clinical data to compare tests, therapies, and real-world clinical interventions in routine care settings.
What are PROSPECT studies (as referenced in the opportunity)?
PROSPECT stands for Prospective Outcome Systems using Patient-specific Electronic data to Compare Tests and therapies. The forum specifically envisioned convening investigators running PROSPECT studies as part of the stakeholder mix.
How much funding was available under this opportunity?
The estimated total funding amount listed was $4,000,000.
Did the opportunity require cost sharing or a match?
No. There was no cost sharing or matching requirement.
When was the opportunity posted and when did it close?
It was posted on December 8, 2009, and closed on January 20, 2010.
When was the archive date for the opportunity?
The archive date was February 20, 2010.
Who was eligible to apply as the lead applicant?
Eligibility was focused on non-profit organizations. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, federally recognized tribal governments, other tribal organizations, units of local government, and eligible federal agencies.
Were for-profit organizations eligible to apply as the lead applicant?
No. Under this FOA, applications from for-profit organizations were not eligible as lead applicants and would be returned without review. However, for-profit entities could participate as consortium members or subcontractors.
Were foreign institutions eligible to apply as the lead applicant?
No. Foreign institutions were not eligible as lead applicants and applications from foreign institutions would be returned without review. Foreign entities could participate as consortium members or subcontractors.
Could ineligible organizations participate in some other way?
Yes. Entities that were not eligible as lead applicants (such as for-profit organizations and foreign institutions) could participate as consortium members or subcontractors.
Were any types of nonprofit organizations explicitly excluded?
Yes. The FOA excluded 501(c)(4) organizations that engage in lobbying.
What was the principal investigator (PI) minimum effort requirement?
The principal investigator was required to commit a minimum of 10 percent effort.
Did AHRQ encourage participation by any specific groups of individuals?
Yes. AHRQ reiterated its standing encouragement for applications involving individuals from underrepresented racial and ethnic groups and individuals with disabilities.
Why was this opportunity tied to the Recovery Act (ARRA)?
The funding was part of the Recovery Act investment aimed at accelerating health research capabilities and near-term impact, especially at a time when electronic health records, registries, and distributed data networks were expanding quickly.
What gap in the field was this EDM forum intended to address?
It was intended to address major gaps in standardization, governance, and trustworthy analytic approaches for using electronic clinical data in comparative effectiveness research.
What was AHRQ trying to achieve by funding a dedicated forum rather than separate individual projects?
AHRQ sought to accelerate progress by convening the right mix of experts and stakeholders to map the toughest obstacles and define workable paths forward for using electronic clinical data in CER, emphasizing shared methods and consensus-building.
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| AHRQ ARRA Recovery Act 2009 Limited Competition AHRQ Institutional National Research Service Award (NRSA) Postdoctoral Comparative Effectiveness Development Training Award (T32) Apply for RFA HS 10 011 Funding Number: RFA HS 10 011 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $900,000 |
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| American Recovery and Reinvestment Act of 2009, Information Technology Professionals in Health Care Competency Examination for Individuals Apply for FOA OC HIT 10 002 Funding Number: FOA OC HIT 10 002 Agency: Office of the National Coordinator Category: Health Recovery Act Funding Amount: $6,000,000 |
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| Recovery Act 2009 Limited Competition Expansion of Research Capability to Study Comparative Effectiveness in Complex Patients (R24) Apply for RFA HS 10 001 Funding Number: RFA HS 10 001 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $500,000 |
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| ARRAOS Recovery Act Limited Competition Behavioral Economics for Nudging the Implementation of Comparative Effectiveness Research Pilot Research (RC4) Apply for RFA OD 10 002 Funding Number: RFA OD 10 002 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $500,000 |
| Recovery Act Limited Competition Comparative Effectiveness Research on Upper Endoscopy in Gastroesophageal Reflux Disease, Eradication Methods for Methicillin Resistant Staphylococcus aureus and Dementia Detection and Management Strategies (RC4) Apply for RFA OD 10 008 Funding Number: RFA OD 10 008 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $500,000 |
| Recovery Act Limited Competition NIH Directors Opportunity for Research in Five Thematic Areas (RC4) Apply for RFA OD 10 005 Funding Number: RFA OD 10 005 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
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| Recovery Act Limited Competition Research On Biosamples From Selected Diabetes Clinical Studies (RC4) Apply for RFA OD 10 010 Funding Number: RFA OD 10 010 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Accelerating Adoption of Comparative Effectiveness Research Results by Providers and Patients (R18) Apply for RFA AE 10 001 Funding Number: RFA AE 10 001 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| Recovery Act Limited Competition Institutional Comparative Effectiveness Research Mentored Career Development Award (KM1) Apply for RFA OD 10 011 Funding Number: RFA OD 10 011 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
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| Recovery Act Limited Competition Program to Enhance NIH supported Global Health Research Involving Human Subjects (S07) Apply for RFA OD 10 006 Funding Number: RFA OD 10 006 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $50,000 |
| ARRA OS Recovery Act 2009 Limited Competition Accelerating Implementation of Comparative Effectiveness Findings on Clinical and Delivery System Interventions by Leveraging AHRQ Networks (R18) Apply for RFA HS 10 014 Funding Number: RFA HS 10 014 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $16,660,000 |
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