Opportunity Information: Apply for RFA AE 10 001
Apply for RFA AE 10 001
- The National Institutes of Health in the health recovery act sector is offering a public funding opportunity titled "ARRA OS Recovery Act 2009 Accelerating Adoption of Comparative Effectiveness Research Results by Providers and Patients (R18)" and is now available to receive applicants.
- This funding opportunity was created on Jan 11, 2010 and posted on Jan 11, 2010.
- Applicants must submit their applications by Mar 11, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $14,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Private institutions of higher education.
- Other Eligible Applicants include the following Integrated health care systems Integrated provider systems Academic Medical Centers Provider consortia Community Health Center Networks Private payers Other non governmental organizations that administer or directly provide health care services Organizations that serve health care consumers University based school (e.g. School of Public Policy or Public Health) Private research institutes
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Opportunity Summary:
The ARRA OS Recovery Act 2009 grant opportunity, titled "Accelerating Adoption of Comparative Effectiveness Research Results by Providers and Patients (R18)," was a National Institutes of Health funding announcement supported with American Recovery and Reinvestment Act of 2009 (ARRA) funds provided to the HHS Office of the Assistant Secretary for Planning and Evaluation (ASPE). The central goal was to move existing comparative effectiveness research (CER) from published evidence into real-world use by patients and clinicians. In practical terms, the program was looking for projects that could close the gap between what CER already shows works best and what actually happens in clinics, hospitals, and health systems, with the expectation that better adoption would both show a return on federal CER investments and improve patient health outcomes.
The opportunity focused on two main types of work. First, applicants were expected to develop and implement evidence-informed, innovative interventions designed to increase the uptake of CER findings, with interventions aimed at providers, patients, or both. Second, applicants needed to rigorously test how well these CER-based adoption strategies work when implemented within a single organization or across multiple organizations and delivery systems, and then analyze whether the intervention produced measurable behavior change. That behavior change could include clinician actions (like prescribing choices, use of diagnostics, adherence to guidelines, or shared decision-making practices) and patient actions (like adherence to medications, engagement in recommended care pathways, follow-up behavior, or informed choices aligned with CER findings).
A key requirement was that proposals had to be explicitly "CER-based," meaning the applicant needed to clearly identify the existing comparative evidence being promoted and justify why that particular body of evidence was appropriate to target for adoption. The program was not primarily about generating brand-new comparative effectiveness findings; it was about translating and implementing what was already known. Because the emphasis was on measurable real-world impact, applicants were expected to use existing measurement systems or build new ones to track adoption and adherence over time. In other words, funded projects needed credible ways to quantify whether clinicians and patients actually changed what they did as a result of the intervention. Where feasible, projects were also encouraged to measure downstream health outcomes, not just process measures, and to examine the underlying factors that drive or hinder adoption (for example, workflow barriers, incentives, organizational culture, patient preferences, communication challenges, or access constraints).
Funding was offered through the NIH R18 mechanism, which is commonly used for research and demonstration projects focused on health services and systems-level interventions. Individual awards were expected to range from $300,000 to $3,000,000, with an anticipated 5 to 10 awards and an estimated total program funding level of about $14,000,000. There was no cost sharing or matching requirement. The opportunity was posted on January 11, 2010, with an application deadline of March 11, 2010, and it was later archived on April 11, 2010.
Eligibility was broad but centered on organizations positioned to implement and evaluate adoption interventions in real care settings. Eligible applicants included private institutions of higher education and other entities such as integrated health care systems, integrated provider systems, academic medical centers, provider consortia, community health center networks, private payers, university-based schools (such as public health or public policy), private research institutes, and other non-governmental organizations that administer or directly provide health care services or serve health care consumers. This mix reflects the program's emphasis on practical deployment of CER adoption strategies across both public and private sector health care environments, including delivery systems and payer-linked settings where policy, incentives, and clinical practice intersect.
Overall, this FOA was designed to fund implementation-focused projects that take credible comparative evidence and build, deploy, and test strategies that make that evidence easier to use, more likely to be trusted, and more consistently applied in day-to-day decisions by clinicians and patients, with careful measurement of adoption, adherence, and any resulting improvements in care and outcomes.
Frequently Asked Questions (FAQs)
What is the "Accelerating Adoption of Comparative Effectiveness Research Results by Providers and Patients (R18)" opportunity?
This was a National Institutes of Health (NIH) funding opportunity supported with American Recovery and Reinvestment Act of 2009 (ARRA) funds provided to the HHS Office of the Assistant Secretary for Planning and Evaluation (ASPE). The purpose was to speed up real-world use of already-published comparative effectiveness research (CER) by clinicians and patients.
What problem was this grant trying to solve?
The program targeted the gap between what existing CER evidence indicates works best and what actually happens in everyday clinical practice. The goal was to improve uptake of proven approaches in clinics, hospitals, and health systems so federal investments in CER translate into measurable changes in care and improved patient outcomes.
What was the central goal of the program?
The central goal was to move existing CER findings from published evidence into routine, real-world use by patients and clinicians through practical, measurable adoption strategies.
Was this grant intended to fund new comparative effectiveness research?
No. The emphasis was not on generating brand-new comparative effectiveness findings. The focus was on translating and implementing what was already known from existing CER, and demonstrating measurable adoption and behavior change as a result.
What kinds of projects were expected to be proposed?
Projects were expected to (1) develop and implement evidence-informed, innovative interventions to increase uptake of CER findings by providers, patients, or both, and (2) rigorously test how well those adoption strategies work in real care settings, whether within a single organization or across multiple organizations and delivery systems.
What does it mean that proposals had to be "CER-based"?
"CER-based" meant applicants needed to clearly identify the specific existing comparative evidence they intended to promote, and justify why that particular body of evidence was appropriate to target for adoption. The intervention had to be grounded in identifiable published comparative evidence.
Who were the intended targets of the interventions?
Interventions could be aimed at providers, patients, or both. The program was designed to support strategies that influence decision-making and behavior at the clinician level, the patient level, or across the clinician-patient interface.
What kinds of provider behavior change did the program expect to measure?
Examples of clinician behavior change included prescribing choices, use of diagnostic tests, adherence to guidelines, and shared decision-making practices aligned with CER findings.
What kinds of patient behavior change did the program expect to measure?
Examples of patient behavior change included medication adherence, engagement in recommended care pathways, follow-up behavior, and informed choices aligned with CER findings.
What did "rigorously test" mean in the context of this opportunity?
The opportunity required applicants to evaluate how well CER adoption strategies work when implemented in real delivery settings and to analyze whether the intervention produced measurable behavior change. Testing could occur within a single organization or across multiple organizations and delivery systems.
Were applicants expected to measure outcomes, or only process changes?
Because the emphasis was on real-world impact, applicants were expected to track adoption and adherence over time. Where feasible, projects were also encouraged to measure downstream health outcomes in addition to process measures.
How were projects expected to measure adoption and adherence?
Applicants were expected to use existing measurement systems or build new measurement approaches capable of credibly quantifying whether clinicians and patients actually changed what they did as a result of the intervention.
Were projects expected to study why adoption succeeds or fails?
Yes. Projects were encouraged to examine factors that drive or hinder adoption, such as workflow barriers, incentives, organizational culture, patient preferences, communication challenges, and access constraints.
What funding mechanism was used?
Funding was offered through the NIH R18 mechanism, which is commonly used for research and demonstration projects focused on health services and systems-level interventions.
How much funding was available per award?
Individual awards were expected to range from $300,000 to $3,000,000.
How many awards were anticipated?
The program anticipated making about 5 to 10 awards.
What was the estimated total funding level for the program?
The estimated total program funding level was about $14,000,000.
Was cost sharing or matching required?
No. There was no cost sharing or matching requirement.
Who was eligible to apply?
Eligibility was broad but centered on organizations positioned to implement and evaluate CER adoption interventions in real care settings. Eligible applicants included private institutions of higher education and entities such as integrated health care systems, integrated provider systems, academic medical centers, provider consortia, community health center networks, private payers, university-based schools (for example, public health or public policy), private research institutes, and other non-governmental organizations that administer or directly provide health care services or serve health care consumers.
What types of settings did the program emphasize?
The program emphasized practical deployment of CER adoption strategies in real-world health care environments across public and private sectors, including delivery systems and payer-linked settings where policy, incentives, and clinical practice intersect.
When was the opportunity posted and when was the deadline?
The opportunity was posted on January 11, 2010, with an application deadline of March 11, 2010.
Is this funding opportunity still active?
No. The opportunity was later archived on April 11, 2010.
What was the expected value of improving CER adoption?
The program anticipated that better adoption of CER findings would demonstrate a return on federal CER investments and improve patient health outcomes by making proven approaches more consistently used in day-to-day clinical and patient decisions.
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| Funding Opportunity |
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| Recovery Act Limited Competition Institutional Comparative Effectiveness Research Mentored Career Development Award (KM1) Apply for RFA OD 10 011 Funding Number: RFA OD 10 011 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Limited Competition Enhanced Registries for Quality Improvement and Comparative Effectiveness Research (R01) Apply for RFA HS 10 020 Funding Number: RFA HS 10 020 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $4,000,000 |
| Recovery Act Limited Competition Framework Programs for Global Health Signature Innovations Initiative (R24) Apply for RFA OD 10 007 Funding Number: RFA OD 10 007 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $250,000 |
| Recovery Act Limited Competition Program to Enhance NIH supported Global Health Research Involving Human Subjects (S07) Apply for RFA OD 10 006 Funding Number: RFA OD 10 006 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $50,000 |
| ARRA OS Recovery Act 2009 Limited Competition Accelerating Implementation of Comparative Effectiveness Findings on Clinical and Delivery System Interventions by Leveraging AHRQ Networks (R18) Apply for RFA HS 10 014 Funding Number: RFA HS 10 014 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $16,660,000 |
| ARRA OS Recovery Act 2009 Limited Competition Comparative Effectiveness Delivery System Evaluation Grants (R01) Apply for RFA HS 10 012 Funding Number: RFA HS 10 012 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: $500,000 |
| ARRA OS Recovery Act 2009 Limited Competition Comparative Effectiveness Delivery System Demonstration Grants (R18) Apply for RFA HS 10 013 Funding Number: RFA HS 10 013 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: Case Dependent |
| ARRA OS Recovery Act 2009 Limited Competition Enhanced State Data for Analysis and Tracking of Comparative Effectiveness Impact Improved Clinical Content and Race Ethnicity Data (R01) Apply for RFA HS 10 010 Funding Number: RFA HS 10 010 Agency: Agency for Health Care Research and Quality Category: Health Recovery Act Funding Amount: Case Dependent |
| Recovery Act Limited Competition The NIH Directors ARRA Funded Pathfinder Award to Promote Diversity in the Scientific Workforce (DP4) Apply for RFA OD 10 013 Funding Number: RFA OD 10 013 Agency: National Institutes of Health Category: Health Recovery Act Funding Amount: $2,000,000 |
| 2010 ARRA Prevention and Wellness Leveraging National Organizations Apply for OS PAW 10 001 Funding Number: OS PAW 10 001 Agency: Office of the Assistant Secretary for Health Category: Health Recovery Act Funding Amount: $1,500,000 |
| ARRA Training in Primary Care Medicine Interdisciplinary and Interprofessional Joint Graduate Degree Apply for HRSA 10 236 Funding Number: HRSA 10 236 Agency: Health Resources and Services Administration Category: Health Recovery Act Funding Amount: Case Dependent |
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| ARRA Training in Primary Care Medicine Administrative Academic Units in Primary Care Apply for HRSA 10 231 Funding Number: HRSA 10 231 Agency: Health Resources and Services Administration Category: Health Recovery Act Funding Amount: Case Dependent |
| American Recovery and Reinvestment Act of 2009, Funding to Beacon Communities Apply for HHS 2010 ONC BC 006 Funding Number: HHS 2010 ONC BC 006 Agency: Office of the National Coordinator Category: Health Recovery Act Funding Amount: $18,000,000 |
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