Assay Development for High Throughput Screening for Nicotinic Receptor Subunits (R21) | Apply Online

Opportunity Information: Apply for RFA DA 11 007

The National Institute on Drug Abuse (NIDA) has announced a grant opportunity titled "Assay Development for High Throughput Screening for Nicotinic Receptor Subunits (R21)." This funding initiative invites applications aimed at creating biological assays that aid in discovering new molecular probes to study the functions of neuronal nicotinic acetylcholine receptors (nAChRs). These receptors, made up of various combinations of membrane-spanning alpha and beta subunits, play a key role in nicotine addiction and related health issues.

The opportunity highlights the importance of specific subunits, particularly those in the 5 3 4 gene cluster linked to nicotine dependency, with particular focus on developing assays for receptor combinations involving subunits 3, 4, 5, and 6. The goal is to create high throughput screening (HTS) assays that can later be submitted to the NIH Molecular Libraries Production Centers Network for identifying biologically active compounds from a vast library of small molecules. The results could lead to the development of selective ligands and potential drug candidates for smoking cessation therapies.

The funding mechanism will use the NIH Exploratory/Developmental (R21) grant format with some modifications. NIDA has set aside approximately $1.5 million for this grant opportunity in 2011, anticipating making around 5 to 7 awards. The size and duration of individual grants will vary based on the proposals submitted, considering the diverse nature of the research topics.

• The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Assay Development for High Throughput Screening for Nicotinic Receptor Subunits (R21)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279 Drug Abuse and Addiction Research Programs.
• This funding opportunity was created on Sep 16, 2010 and posted on Sep 16, 2010.
• Applicants must submit their applications by Jan 18, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2025.)
• The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
• Each selected applicant is eligible to receive up to $150,000.00 in funding.
• Eligible applicants include: Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) County governments Public housing authorities/Indian housing authorities City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Special district governments Private institutions of higher education Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education For profit organizations other than small businesses.
• Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.

Apply for RFA DA 11 007

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