Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01) | Apply Online

Opportunity Summary:

The National Cancer Institute (NCI), within the National Institutes of Health (NIH), released this Funding Opportunity Announcement (FOA) to strengthen the foundational capabilities of Cancer Epidemiology Cohorts (CECs) and to advance methodological research that improves how cohort-based cancer epidemiology is conducted. The central idea is to provide targeted, practical infrastructure support for the core functions that make large, long-running cohort studies useful and sustainable over time. Rather than focusing on a single hypothesis-driven research project, this opportunity emphasizes the shared systems, resources, and methods that allow cohorts to reliably collect, manage, and use data and biospecimens, maintain participant follow-up, and generate high-quality evidence about cancer causes, prevention, detection, and related outcomes. Importantly, the infrastructure supported under this FOA can be used for either existing cohorts or new cohorts, and it is explicitly intended to help cohorts that may already be funded through other mechanisms within NCI, particularly through the Epidemiology and Genetics Program (EGRP) and other parts of the Division of Cancer Control and Population Sciences (DCCPS).

The award mechanism is a U01 cooperative agreement, which signals a collaborative relationship between the funded investigators and NIH/NCI program staff. In practice, cooperative agreements generally involve substantial scientific or programmatic involvement from the funding agency compared to a standard research project grant. For applicants, that typically means the work is expected to align closely with NCI priorities for cohort infrastructure and methods development, and there may be coordinated activities, shared expectations around deliverables, or participation in broader cohort-related initiatives depending on the specific terms of the award.

The announcement lists the opportunity as discretionary funding and associates it with health and education-related activities. It is tied to multiple CFDA numbers that cover a broad range of cancer research areas, including cancer cause and prevention research (93.393), cancer detection and diagnosis research (93.394), cancer biology research (93.396), and cancer centers support grants (93.397). The FOA does not require cost sharing or matching, which reduces barriers for organizations that may not have resources to provide non-federal matching funds.

Funding levels and the number of awards are not specified as fixed amounts. Instead, NCI indicates that the total funds awarded and the number of awards will depend on the quality of applications received, along with the proposed duration and costs. This structure is common when an agency wants flexibility to support a variable number of strong proposals and to scale awards according to the scope of proposed infrastructure and methodological work.

Eligibility is broad and includes many organization types that might operate, host, or support epidemiology cohorts. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, state governments, U.S. territories or possessions, nonprofit organizations (including those with and without 501(c)(3) status, with the exception noted for institutions of higher education), small businesses, and for-profit organizations other than small businesses. The FOA also allows certain additional applicant categories, including eligible federal agencies, foreign (non-U.S.) entities, and regional organizations, indicating that NCI was open to supporting cohort infrastructure and methods work that could involve international collaboration or be housed outside the United States when appropriate.

Key administrative details in the source information include the funding opportunity number PAR 10 283 and the title "Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01)." The FOA was posted on September 16, 2010, with an original closing date of July 10, 2013, and a listed current closing date of May 7, 2011, with an archive date of June 7, 2011. For applicants or interested parties who cannot access the full announcement or have technical problems with the online listing, the notice provides contact information for the NIH Office of Extramural Research (OER) webmaster via FBOWebmaster@OD.NIH.GOV and points to the full FOA text hosted on the NIH grants site at http://grants.nih.gov/grants/guide/pa-files/PAR-10-283.html.

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