Opportunity Information: Apply for RFA HL 17 001
Apply for RFA HL 17 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Asthma Empowerment Collaborations to Reduce Childhood Asthma Disparities (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Dec 9, 2014 and posted on Dec 9, 2014.
- Applicants must submit their applications by Nov 16, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Special district governments Public housing authorities/Indian housing authorities Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Small businesses County governments State governments City or township governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Asthma Empowerment Collaborations to Reduce Childhood Asthma Disparities (U01) (Funding Opportunity Number RFA HL 17 001) is a National Institutes of Health cooperative agreement grant designed to fund clinical trials that test community-based Asthma Care Implementation Programs (ACIPs) for children who are at high risk of poor asthma outcomes. The core idea is to move beyond isolated clinical care and instead evaluate a comprehensive, real-world program that can reduce disparities in childhood asthma by coordinating proven interventions across the settings where children live, learn, and receive care.
The ACIP model required under this opportunity is intentionally multi-sector and community-tailored. Applicants are expected to build a program that fits the needs of the specific U.S. community where the study will take place and to integrate interventions with demonstrated efficacy from four sectors: medical care, family, home, and community. In practice, that means a successful application would not simply propose education in a clinic or a single home visit program; it would assemble and coordinate multiple evidence-based components that work together, such as guideline-based clinical management and medication access supports (medical care), caregiver training and adherence support (family), home environmental assessments and remediation strategies targeting triggers (home), and linkages with schools, housing, local public health, or community health workers (community). A key expectation is that investigators already have established collaborations with partners representing each of these four sectors, and those partners must be committed to contributing resources to make the ACIP feasible.
The funded projects must include a clinical trial that directly tests whether the ACIP improves asthma outcomes compared with an appropriate comparator or comparators. The announcement emphasizes that the trial design must be rigorous enough to evaluate program impact, while also reflecting how the program would operate in the community. In addition to the intervention period, the project must include a subsequent observation phase to assess sustainability, recognizing that short-term improvements are not enough if the program falls apart once intensive research support ends. Because these are implementation-focused trials, the outcomes cannot be limited to clinical endpoints alone. A critical requirement is that endpoints include measures of the process used to implement the evidence-based interventions, meaning applicants need to track and evaluate implementation quality and fidelity (how well the intervention is delivered as intended), reach and uptake (who actually receives it), and other practical implementation metrics that explain why the program did or did not work.
Sustainability and dissemination are central to the purpose of this funding opportunity. Given that ACIPs may change how local systems deliver asthma care, the FOA requires applicants to formally assess sustainability during the project period, not as an afterthought. Investigators must also plan for dissemination beyond their own community, signaling NIH interest in generating lessons, tools, and best practices that can be adopted elsewhere, especially in communities facing similar asthma disparities. This dissemination expectation pushes applicants to think about scalability, local ownership, ongoing financing or resource commitments, and how program elements could be packaged and shared with other health systems, schools, housing partners, or community organizations.
This FOA uses a cooperative agreement (U01) mechanism, which means NIH is expected to have substantial involvement with awardees rather than acting only as a funder. The structure is intended to enable collaboration among investigators across funded projects on shared implementation metrics, ongoing quality improvement activities throughout the funding period, and the development of best practices. In other words, awardees are not just running independent trials; they are also contributing to a coordinated effort to improve how implementation is measured and how effective asthma care programs can be delivered in diverse communities.
Administratively, this opportunity falls under the Health activity category and is associated with CFDA 93.838 (Lung Diseases Research). NIH anticipated making about four awards, and it did not require cost sharing or matching. The opportunity was posted December 9, 2014, with an original and final closing date of November 16, 2016, and it was archived December 17, 2016. A wide range of applicants were eligible, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses), and various units of government (state, county, city/township, special district, independent school districts, public housing authorities), as well as tribal governments and tribal organizations. The eligibility information also highlighted inclusion of institutions serving specific populations (for example HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian Serving Institutions), and it allowed foreign components as defined by NIH policy, while stating that non-U.S. entities and non-U.S. components of U.S. organizations were not eligible to apply.
Overall, the opportunity is best understood as funding implementation-oriented, community-embedded asthma trials that combine proven interventions across medical, family, home, and community settings, measure both health outcomes and the practical mechanics of implementation, and generate sustainable, shareable models for reducing childhood asthma disparities at the community level.
Frequently Asked Questions (FAQs)
What is the Asthma Empowerment Collaborations to Reduce Childhood Asthma Disparities (U01) opportunity?
It is a National Institutes of Health (NIH) cooperative agreement grant opportunity that supports clinical trials testing community-based Asthma Care Implementation Programs (ACIPs) for children at high risk of poor asthma outcomes, with a focus on reducing childhood asthma disparities.
What is the Funding Opportunity Number (FON) for this program?
The Funding Opportunity Number is RFA HL 17 001.
What type of NIH funding mechanism is used?
This opportunity uses a cooperative agreement mechanism (U01), meaning NIH expects substantial involvement with awardees during the project.
How is a U01 cooperative agreement different from a typical grant?
Under a U01, NIH is expected to be substantially involved with funded projects, supporting collaboration across awardees, alignment on shared implementation metrics, and ongoing quality improvement activities over the funding period (not simply providing funds and stepping back).
What is the main purpose of the funded projects?
The purpose is to evaluate a comprehensive, real-world, community-embedded asthma program that coordinates proven interventions across multiple settings (where children live, learn, and receive care) to improve asthma outcomes and reduce disparities.
What is an Asthma Care Implementation Program (ACIP) in this FOA?
An ACIP is a multi-sector, community-tailored program that integrates evidence-based interventions across four required sectors: medical care, family, home, and community.
What are the four sectors that must be included in the ACIP model?
The program must integrate interventions with demonstrated efficacy from: (1) medical care, (2) family, (3) home, and (4) community.
Does the ACIP have to be tailored to a specific community?
Yes. Applicants are expected to build an ACIP that fits the needs of the specific U.S. community where the study will take place.
Can an application focus on only one setting, like a clinic-based education program?
No. The description emphasizes that the ACIP should move beyond isolated clinical care and should not be limited to a single-component approach (for example, education only in a clinic or a single home visit program). The expectation is a coordinated package of multiple evidence-based components across the four sectors.
What are examples of interventions that could fit within the required sectors?
The opportunity description gives examples such as guideline-based clinical management and medication access supports (medical care), caregiver training and adherence support (family), home environmental assessments and remediation strategies targeting triggers (home), and linkages with schools, housing, local public health, or community health workers (community).
Do applicants need to have partners in place across all four sectors?
Yes. A key expectation is that investigators already have established collaborations with partners representing each of the four sectors, and that those partners are committed to contributing resources to make the ACIP feasible.
Is a clinical trial required under this opportunity?
Yes. Funded projects must include a clinical trial that directly tests whether the ACIP improves asthma outcomes compared with an appropriate comparator or comparators.
What does the FOA mean by an "appropriate comparator"?
The information provided states that the ACIP must be tested against an appropriate comparator or comparators, but it does not specify what those comparators must be. The key requirement is that the trial design supports a rigorous evaluation of program impact while reflecting real-world community operation.
Does the project need to include follow-up after the intervention ends?
Yes. In addition to the intervention period, the project must include a subsequent observation phase to assess sustainability, reflecting that short-term improvements are not sufficient if the program is not sustained.
Are clinical outcomes alone enough for study endpoints?
No. The opportunity requires endpoints that include measures of the process used to implement the evidence-based interventions, not only clinical endpoints.
What kinds of implementation endpoints are expected?
Applicants are expected to track and evaluate implementation quality and fidelity (how well interventions are delivered as intended), reach and uptake (who actually receives them), and other practical implementation metrics that help explain why the program did or did not work.
How important are sustainability and dissemination in this FOA?
They are central. Applicants must formally assess sustainability during the project period and plan for dissemination beyond their own community, with an emphasis on generating lessons, tools, and best practices that can be adopted elsewhere.
What does dissemination mean in the context of this opportunity?
Based on the description, dissemination refers to planning to share program lessons, tools, and best practices beyond the study community so that other communities (especially those facing similar asthma disparities) can adopt effective approaches.
What does the FOA emphasize about scalability and local ownership?
The dissemination expectation pushes applicants to think about scalability, local ownership, ongoing financing or resource commitments, and how program elements could be packaged and shared with other health systems, schools, housing partners, or community organizations.
Will awardees be expected to collaborate with other funded projects?
Yes. The cooperative agreement structure is intended to enable collaboration among investigators across funded projects on shared implementation metrics, ongoing quality improvement activities, and the development of best practices.
What is the activity category and CFDA number associated with this opportunity?
The opportunity is associated with the Health activity category and CFDA 93.838 (Lung Diseases Research).
How many awards did NIH anticipate making?
NIH anticipated making about four awards.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
When was this opportunity posted and when did it close?
It was posted on December 9, 2014. The original and final closing date was November 16, 2016. It was archived on December 17, 2016.
Is this opportunity currently open for applications?
No. Based on the provided information, it is archived and had a final closing date of November 16, 2016.
What types of organizations were eligible to apply?
A wide range of applicants were eligible, including public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses), and multiple types of government entities (state, county, city/township, special district, independent school districts, and public housing authorities), as well as tribal governments and tribal organizations.
Were institutions serving specific populations included in the eligibility list?
Yes. The eligibility information highlighted inclusion of institutions serving specific populations, including HBCUs, Hispanic-serving institutions, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian Serving Institutions.
Are foreign components allowed?
Yes. The opportunity allowed foreign components as defined by NIH policy.
Are non-U.S. entities eligible to apply?
No. The eligibility language states that non-U.S. entities are not eligible to apply.
Are non-U.S. components of U.S. organizations eligible to apply?
No. The eligibility language states that non-U.S. components of U.S. organizations were not eligible to apply.
What kind of research is this opportunity best described as supporting?
It supports implementation-oriented, community-embedded asthma trials that coordinate proven interventions across medical, family, home, and community settings, measure both health outcomes and implementation mechanics, and generate sustainable, shareable models to reduce childhood asthma disparities.
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