Opportunity Information: Apply for RFA AI 12 060
Apply for RFA AI 12 060
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Autoimmunity Centers of Excellence, Basic Research Program (U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 15, 2013 and posted on Jan 15, 2013.
- Applicants must submit their applications by Jun 13, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) State governments Special district governments For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses County governments Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Public and State controlled institutions of higher education City or township governments Native American tribal governments (Federally recognized) Private institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Autoimmunity Centers of Excellence (ACE), Basic Research Program (U19) funding opportunity (RFA-AI-12-060) is an NIH cooperative agreement intended to build and support a coordinated, multi-institution research network focused on improving the understanding and treatment of autoimmune diseases. The ACE program is structured around the idea that close, ongoing collaboration between basic scientists and clinical investigators can speed up progress by connecting mechanistic discovery to real-world therapeutic testing. Under this reissued announcement, NIH separates what had previously been integrated ACE Centers into two complementary tracks: a Basic Research Program (this FOA) and a separate Clinical Research Program (covered by a companion FOA). Even though the programs are split for funding and organizational purposes, the design is explicitly network-based, meaning the basic and clinical teams are expected to work together rather than operate as isolated projects.
The scientific emphasis for the Basic Research Program is on fundamental and translational immunology that can explain how immune-modulating therapies work in autoimmune disease settings. A central expectation is that Basic ACE investigators will collaborate with the Clinical ACE to design and carry out mechanistic and immunologic studies that align with agents being tested in clinical trials. In practical terms, this means basic research teams are positioned to help identify and measure biological pathways, immune cell behaviors, and molecular signatures that clarify mechanism of action, inform why a therapy helps or fails, and potentially guide better therapeutic selection or future intervention strategies. The cooperative agreement mechanism (U19) also signals that NIH intends to have substantial scientific involvement in the program, with an emphasis on coordinated planning, shared goals, and active program management across the network rather than purely investigator-directed work.
From an administrative and funding standpoint, the opportunity is categorized as discretionary funding and uses the cooperative agreement instrument. The estimated total funding level listed is $5,000,000. No cost sharing or matching is required. The FOA was posted on January 15, 2013, with an original and current closing date of June 13, 2013, and an archive date of July 14, 2013. The program sits within NIH and is tied to CFDA areas 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research), reflecting its immunology and infection-related scientific home even though the diseases of interest are autoimmune.
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and certain non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a range of government bodies (state, county, city/township, special district, and independent school districts). Tribal governments and tribal organizations are included, as are public housing authorities/Indian housing authorities. The FOA also explicitly recognizes eligibility for several institution types and community-serving categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions, along with faith-based or community-based organizations and eligible federal agencies. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are not eligible; additionally, foreign components as defined by NIH policy are not allowed.
Overall, the opportunity is best understood as a network-building, team-science center-style program for basic autoimmune research, designed to plug directly into ongoing and planned clinical testing of immune-modulating therapies. The key distinguishing feature is the required integration with clinical efforts to produce high-value mechanistic insight, rather than conducting basic immunology in a vacuum. For full details, NIH provided an announcement link through the NIH Grants Guide (http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-12-060.html), and listed NIH Office of Extramural Research webmaster contacts for access or linking issues.
Frequently Asked Questions (FAQs)
What is the Autoimmunity Centers of Excellence (ACE) Basic Research Program (U19)?
The ACE Basic Research Program is an NIH cooperative agreement (U19) funding opportunity (RFA-AI-12-060) intended to build and support a coordinated, multi-institution research network focused on improving the understanding and treatment of autoimmune diseases through basic and translational immunology.
What is the main goal of this funding opportunity?
The main goal is to support a network of basic research teams that work closely with clinical investigators to generate mechanistic and immunologic insights that help explain how immune-modulating therapies work (or do not work) in autoimmune disease settings, especially in the context of agents being tested in clinical trials.
Is this opportunity focused on building a research network or funding standalone projects?
It is explicitly network-based. The program is designed around coordinated, multi-institution collaboration rather than isolated, standalone projects.
What makes this FOA different from traditional basic research grants?
A key distinguishing feature is the required integration with clinical efforts. Basic research is expected to connect mechanistic discovery to real-world therapeutic testing by aligning studies with immune-modulating agents being tested in clinical trials, rather than conducting basic immunology without a clinical interface.
How does the Basic Research Program relate to the Clinical Research Program?
Under this reissued announcement, NIH separated what had previously been integrated ACE Centers into two complementary tracks: a Basic Research Program (this FOA) and a separate Clinical Research Program (covered by a companion FOA). Even though they are split for funding and organizational purposes, the design expects basic and clinical teams to work together as a coordinated network.
What kinds of research are emphasized under the Basic Research Program?
The scientific emphasis is on fundamental and translational immunology that can clarify how immune-modulating therapies operate in autoimmune disease. This includes mechanistic and immunologic studies that investigate biological pathways, immune cell behaviors, and molecular signatures relevant to therapeutic mechanism of action and outcomes.
What is meant by “mechanistic and immunologic studies†in this program?
In practical terms, these are studies designed to identify and measure the pathways and immune responses affected by therapies, helping explain why a therapy helps or fails, and potentially informing better therapeutic selection or future intervention strategies.
Are applicants expected to collaborate with clinical trial efforts?
Yes. A central expectation is that Basic ACE investigators will collaborate with the Clinical ACE to design and carry out mechanistic and immunologic studies that align with agents being tested in clinical trials.
What funding mechanism does this opportunity use?
The opportunity uses the NIH cooperative agreement mechanism (U19).
What does a cooperative agreement (U19) imply about NIH involvement?
The cooperative agreement mechanism signals that NIH intends to have substantial scientific involvement, with coordinated planning, shared goals, and active program management across the network, rather than purely investigator-directed work.
How is the funding categorized?
The opportunity is categorized as discretionary funding and uses a cooperative agreement instrument.
What is the estimated total funding level for this opportunity?
The estimated total funding level listed for this FOA is $5,000,000.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
When was the FOA posted?
The FOA was posted on January 15, 2013.
What is the application closing date?
The original and current closing date listed is June 13, 2013.
When is (or was) the archive date for this FOA?
The archive date listed is July 14, 2013.
Which NIH program areas (CFDA) are associated with this opportunity?
This FOA is tied to CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Why are the CFDA areas related to infectious diseases if the topic is autoimmunity?
The CFDA areas reflect the immunology and infection-related scientific home of the program within NIH, even though the diseases of interest are autoimmune.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and certain non-501(c)(3) entities); for-profit organizations (including small businesses and other for-profits); and government bodies such as state, county, city/township, special district, and independent school districts.
Are Tribal governments or Tribal organizations eligible?
Yes. Tribal governments and Tribal organizations are included in the eligible applicant categories.
Are public housing authorities eligible?
Yes. Public housing authorities/Indian housing authorities are included as eligible applicants.
Are minority-serving institutions (MSIs) specifically recognized as eligible?
Yes. The FOA explicitly recognizes eligibility for several institution types and community-serving categories, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, and Asian American Native American Pacific Islander Serving Institutions.
Are faith-based or community-based organizations eligible?
Yes. The FOA notes eligibility for faith-based or community-based organizations.
Are federal agencies eligible to apply?
Yes. The FOA indicates that eligible federal agencies are included among eligible applicants.
Are foreign institutions eligible to apply?
No. Foreign institutions are not eligible to apply under this FOA.
Can a U.S. organization include a non-U.S. component in its application?
No. Non-U.S. components of U.S. organizations are not eligible under this FOA.
Are foreign components allowed under NIH policy for this opportunity?
No. The FOA states that foreign components as defined by NIH policy are not allowed.
What is the overall purpose of splitting ACE into Basic and Clinical tracks?
NIH separated what had been integrated ACE Centers into two complementary tracks for funding and organizational purposes, while still maintaining an explicitly network-based design that expects close coordination between basic and clinical teams.
Where can applicants find the official NIH announcement?
The FOA is available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/rfa-files/RFA-AI-12-060.html
Who is listed for help with access or linking issues?
NIH provided NIH Office of Extramural Research webmaster contacts for access or linking issues related to the announcement.
Browse more opportunities from the same category: Health
Next opportunity: Autoimmunity Centers of Excellence, Clinical Research Program (UM1)
Previous opportunity: DoD Applied Research and Advanced Technology Development Psychological Health Award
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for RFA AI 12 060
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (RFA AI 12 060) also looked into and applied for these:
| Funding Opportunity |
|---|
| Autoimmunity Centers of Excellence, Clinical Research Program (UM1) Apply for RFA AI 12 059 Funding Number: RFA AI 12 059 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Family Planning and Reproductive Health Methods APS Apply for SOL OAA 13 000024 Funding Number: SOL OAA 13 000024 Agency: Agency for International Development Category: Health Funding Amount: $80,000,000 |
| Statewide Consumer Network Grant Apply for SM 13 004 Funding Number: SM 13 004 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $70,000 |
| Implementing Public Health Programs and Strengthening Public Health Capacity in Guatemala and Central American Apply for CDC RFA GH13 1306 Funding Number: CDC RFA GH13 1306 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $4,000,000 |
| Engaging Parents in Prevention of Child Sexual Abuse and Sexual Risk Behaviors Targeting Youth Scaling up the Implementation of Families Matter in the United Republic of Tanzania under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1324 Funding Number: CDC RFA GH13 1324 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,200,000 |
| Clinical Neuroscience and Entertainment Software Pilot Partnership Program to Develop Neuropsychiatric Interventions (R43/R44) Apply for RFA MH 14 010 Funding Number: RFA MH 14 010 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition Revisions for DNA Collection from Existing Longitudinal Aging Cohorts in Africa (R01) Apply for RFA AG 13 018 Funding Number: RFA AG 13 018 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIMHD Minority Health and Health Disparities International Research Training (T37) Apply for RFA MD 13 002 Funding Number: RFA MD 13 002 Agency: National Institutes of Health Category: Health Funding Amount: $250,000 |
| Biodynamics Grant Opportunity Apply for 13 01 Funding Number: 13 01 Agency: DOT FAA Aviation Research Grants Category: Health Funding Amount: $750,000 |
| Small Rural Hospital Improvement Grant Program (SHIP) Apply for HRSA 13 163 Funding Number: HRSA 13 163 Agency: Health Resources and Services Administration Category: Health Funding Amount: $9,000 |
| New Access Point Grants Apply for HRSA 13 228 Funding Number: HRSA 13 228 Agency: Health Resources and Services Administration Category: Health Funding Amount: $650,000 |
| Saving Lives at Birth A Grand Challenge for Development (Round 3) Apply for RFA OAA 13 000004 Funding Number: RFA OAA 13 000004 Agency: Agency for International Development Category: Health Funding Amount: Case Dependent |
| Strengthen Brazils National Response to HIV and other diseases through innovative and evidence based approaches in laboratory, strategic information, prevention and care activities and foster partnerships between Brazil, Angola and Mozambique (PEPFAR Apply for CDC RFA GH13 1343 Funding Number: CDC RFA GH13 1343 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $3,500,000 |
| Tanzanian Ministry of Health and Social Welfare System Strengthening for Enhanced Evidence Based Decision Making and Management and Delivery of Quality Health Services in the United Republic of Tanzania under the Presidents Emergency Plan for AIDS Re Apply for CDC RFA GH13 1319 Funding Number: CDC RFA GH13 1319 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $2,000,000 |
| Rural Training Track Technical Assistance Demonstration Program Apply for HRSA 13 247 Funding Number: HRSA 13 247 Agency: Health Resources and Services Administration Category: Health Funding Amount: $300,000 |
| Modification 1 Questions and Answer to the APS Apply for APS 442 13 000001 Funding Number: APS 442 13 000001 Agency: Cambodia USAID Phnom Penh Category: Health Funding Amount: $100,000 |
| Drug Free Communities (DFC) Support Program Apply for SP 13 002 Funding Number: SP 13 002 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $125,000 |
| Support for Community Vital Registration in the Republic of Zambia under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1349 Funding Number: CDC RFA GH13 1349 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,500,000 |
| HIV care and treatment services in the Dukwi refugee camp in Botswana under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1355 Funding Number: CDC RFA GH13 1355 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $500,000 |
| The Namibian Mechanism for Public Health and Medical Education (NAM PHAME) under the Presidents Emergency Plan for AIDS Relief (PEPFAR) Apply for CDC RFA GH13 1358 Funding Number: CDC RFA GH13 1358 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,200,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "RFA AI 12 060", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.