Opportunity Information: Apply for RFA AI 12 059
Apply for RFA AI 12 059
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Autoimmunity Centers of Excellence, Clinical Research Program (UM1)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.855 Allergy and Infectious Diseases Research 93.856 Microbiology and Infectious Diseases Research.
- This funding opportunity was created on Jan 15, 2013 and posted on Jan 15, 2013.
- Applicants must submit their applications by Jun 13, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,200,000.00 to eligible and selected applicants.
- Eligible applicants include: Private institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) City or township governments County governments Public housing authorities/Indian housing authorities Small businesses Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The Autoimmunity Centers of Excellence, Clinical Research Program (UM1) funding opportunity (RFA-AI-12-059) is a National Institutes of Health (NIH) cooperative agreement designed to support participation in the Autoimmunity Centers of Excellence (ACE) program, a coordinated research network focused on improving the understanding and treatment of autoimmune diseases. The ACE program is built around the idea that tightly coordinated collaboration between basic scientists and clinical researchers can move the field faster than isolated efforts, helping translate mechanistic discoveries into better therapeutic strategies and, conversely, using clinical observations to sharpen basic research questions.
For this reissuance, NIH restructures the ACE program by splitting what were previously integrated Centers into two distinct but intentionally linked components: a Basic Research Program and a Clinical Research Program. This particular FOA solicits applications specifically for the Clinical Research Program, while a companion FOA covers the Basic Research Program. Even though the programs are separated administratively, they are expected to function as a unified, cooperative network. Clinical ACE awardees are meant to work closely with Basic ACE investigators to jointly design and conduct studies that examine mechanisms of action for immune-modulating agents being tested in clinical trials. In practical terms, that emphasis points toward clinical research that is not only about whether an intervention works, but also about understanding how it affects immune pathways, biomarkers, and disease-relevant mechanisms in humans.
The award mechanism is a UM1 cooperative agreement, meaning the project is supported through an assistance relationship where NIH typically has substantial programmatic involvement compared with a standard research project grant. The opportunity sits within NIH health-related research and is associated with CFDA numbers 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research). Cost sharing or matching is not required. The estimated total funding listed for the opportunity is $1,200,000.
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include public and private institutions of higher education, nonprofit organizations with or without 501(c)(3) status, state and local governments (including counties, cities/townships, special districts, and independent school districts), public housing authorities/Indian housing authorities, tribal governments and tribal organizations (including tribally controlled colleges and universities), small businesses, and for-profit organizations (other than small businesses). The FOA also explicitly recognizes eligibility for a wide range of institution types such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI organizations, as well as faith-based or community-based organizations and certain federal agencies. At the same time, the announcement is clear that foreign institutions are not eligible to apply, non-U.S. components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.
Key dates show the announcement was posted and created on January 15, 2013, with an original and current closing date of June 13, 2013, and an archive date of July 14, 2013. The full funding announcement was made available through the NIH Grants Guide, and the provided contact for access or technical problems is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
FAQs: Autoimmunity Centers of Excellence (ACE), Clinical Research Program (UM1) - RFA-AI-12-059
What is this funding opportunity?
This opportunity is the Autoimmunity Centers of Excellence (ACE), Clinical Research Program (UM1) funding opportunity announcement (FOA) RFA-AI-12-059. It is a National Institutes of Health (NIH) cooperative agreement intended to support participation in the ACE program, a coordinated research network focused on improving the understanding and treatment of autoimmune diseases.
What is the main purpose of the ACE program?
The ACE program is designed to accelerate progress in autoimmune disease research by promoting tightly coordinated collaboration between basic scientists and clinical researchers. The goal is to speed translation of mechanistic discoveries into therapeutic strategies and to use clinical observations to refine and strengthen basic research questions.
Is this FOA for basic research, clinical research, or both?
This FOA solicits applications specifically for the Clinical Research Program. NIH restructured the ACE program so that what had been integrated Centers are now split into two linked components: a Basic Research Program and a Clinical Research Program. A separate, companion FOA covers the Basic Research Program.
How are the Clinical and Basic ACE Programs expected to work together?
Although the Basic and Clinical Programs are separated administratively, they are expected to function as a unified, cooperative network. Clinical ACE awardees are intended to work closely with Basic ACE investigators to jointly design and conduct studies, particularly those that examine mechanisms of action for immune-modulating agents being tested in clinical trials.
What kinds of clinical studies are emphasized under this Clinical Research Program?
The emphasis is on clinical research that goes beyond evaluating whether an intervention works. Clinical studies are expected to help understand how immune-modulating agents affect immune pathways, biomarkers, and disease-relevant mechanisms in humans, with a focus on mechanism-of-action questions within the context of clinical trials.
What is the award mechanism for this opportunity?
The award mechanism is a UM1 cooperative agreement.
What does it mean that this is a cooperative agreement (UM1)?
A UM1 cooperative agreement is an assistance mechanism where NIH typically has substantial programmatic involvement compared with a standard research project grant. In other words, the project is supported through a relationship that generally involves active NIH participation consistent with the cooperative agreement structure.
What is the program/network called that awardees would join?
Awardees would participate in the Autoimmunity Centers of Excellence (ACE) program, described as a coordinated research network.
What agency is offering this grant?
The opportunity is offered through the National Institutes of Health (NIH).
What CFDA numbers are associated with this opportunity?
The opportunity is associated with CFDA 93.855 (Allergy and Infectious Diseases Research) and 93.856 (Microbiology and Infectious Diseases Research).
Is cost sharing or matching required?
No. The FOA states that cost sharing or matching is not required.
How much total funding is estimated for this opportunity?
The estimated total funding listed for the opportunity is $1,200,000.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and governmental entities. Eligible applicants include:
- Public and private institutions of higher education
- Nonprofit organizations with or without 501(c)(3) status
- State governments
- Local governments (including counties, cities/townships, special districts, and independent school districts)
- Public housing authorities/Indian housing authorities
- Tribal governments and tribal organizations (including tribally controlled colleges and universities)
- Small businesses
- For-profit organizations (other than small businesses)
Are minority-serving institutions and community-based organizations included in eligible applicants?
Yes. The FOA explicitly recognizes eligibility for a wide range of institution types, including HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and AANAPISI organizations. It also notes eligibility for faith-based or community-based organizations.
Are any federal entities eligible to apply?
Yes. The FOA indicates that certain federal agencies are included among eligible applicants.
Are foreign institutions eligible to apply?
No. The FOA states that foreign institutions are not eligible to apply.
Can a U.S. organization include a non-U.S. component?
No. The FOA states that non-U.S. components of U.S. organizations are not eligible.
Are foreign components allowed under NIH policy for this FOA?
No. The FOA states that foreign components (as defined by NIH policy) are not allowed.
When was this FOA posted and created?
The announcement was posted and created on January 15, 2013.
What was the application closing date?
The FOA lists an original and current closing date of June 13, 2013.
When was this FOA archived?
The archive date listed is July 14, 2013.
Where was the full funding announcement made available?
The full funding announcement was made available through the NIH Grants Guide.
Who should be contacted for access or technical problems related to the announcement?
The provided contact for access or technical problems is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
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