Opportunity Information: Apply for PAR 12 095

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Basic Cancer Research in Cancer Health Disparities (U01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research 93.399 Cancer Control.
  • This funding opportunity was created on Feb 2, 2012 and posted on Feb 2, 2012.
  • Applicants must submit their applications by Nov 20, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $250,000.00 in funding.
  • Eligible applicants include: County governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses City or township governments Independent school districts Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) State governments Public and State controlled institutions of higher education Special district governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Basic Cancer Research in Cancer Health Disparities (U01) opportunity (Funding Opportunity Number PAR-12-095) was a National Institutes of Health (NIH) funding announcement led by the National Cancer Institute (NCI), specifically involving the Center to Reduce Cancer Health Disparities (CRCHD) along with NCI's Division of Cancer Biology (DCB) and Division of Cancer Prevention (DCP). The central purpose of the program was to stimulate and support basic, mechanistic research that digs into the biological and genetic drivers behind cancer health disparities. In other words, it was aimed at studies that go beyond describing unequal outcomes and instead try to explain, at a fundamental level, why certain populations experience different cancer risks, tumor behavior, responses to prevention strategies, or outcomes, based on underlying biologic or genetic factors.

This announcement used the U01 cooperative agreement mechanism, meaning funded projects were expected to involve an active partnership with NIH/NCI program staff rather than operating as fully independent investigator-initiated grants. The intent was to fund innovative research programs that could clarify biological mechanisms contributing to disparities, including studies that create or refine research tools needed to do that work well. The FOA explicitly encouraged projects that might involve development and testing of new methodologies and experimental models, mechanistic studies of previously identified biological factors linked to disparities, and secondary analyses of existing datasets when those analyses could reveal biologic or genetic mechanisms. It also left room for basic research connected to prevention, as long as it remained focused on mechanistic understanding relevant to disparity-related differences.

A major theme of the opportunity was capacity-building for the field. Beyond producing publishable findings, the program was designed to help grow a nationwide cohort of scientists with strong basic research expertise specifically focused on cancer health disparities. Part of that vision included generating shared resources and practical tools that would make future disparity-focused basic research more feasible and rigorous, such as well-annotated biospecimen collections, cell lines, and validated methods and models tailored to studying disparity-associated biology. In effect, the program was not just funding individual projects but also trying to strengthen the scientific infrastructure and workforce needed to sustain this area of research over the long term.

From an administrative standpoint, this was a discretionary funding opportunity categorized under education and health-related research activity areas, and it aligned with multiple NCI-related CFDA listings: 93.393 (Cancer Cause and Prevention Research), 93.396 (Cancer Biology Research), and 93.399 (Cancer Control). The announcement indicated there was no cost-sharing or matching requirement. The posting date and creation date were February 2, 2012, with an original and current closing date listed as November 20, 2014, and an archive date of December 21, 2014. The listed award ceiling was $250,000, signaling an upper limit referenced in the source summary for funding levels under this announcement.

Eligibility was broad and intentionally inclusive to attract a wide range of institutions and organizational types capable of contributing to this research space. Eligible applicants included public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) organizations), small businesses and other for-profit organizations (with small businesses explicitly called out), and multiple levels of government entities (state, county, city/township, special district governments), as well as independent school districts and public housing authorities/Indian housing authorities. The eligibility language also emphasized inclusion of institutions and organizations often central to health disparity work, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and other tribal organizations and governments (including federally recognized tribal governments). The FOA further allowed non-U.S. entities to apply, permitted non-U.S. components of U.S. organizations, and allowed foreign components as defined under NIH policy, reflecting an openness to international collaboration or expertise when relevant to the science.

For reference and full details, the FOA was hosted through the NIH grants guide (link provided in the source: http://grants.nih.gov/grants/guide/pa-files/PAR-12-095.html). The provided contact route for access or technical issues was the NIH Office of Extramural Research (OER) webmaster email (FBOWebmaster@OD.NIH.GOV), which was included to help applicants who had trouble reaching the full announcement online.

Frequently Asked Questions (FAQs): Basic Cancer Research in Cancer Health Disparities (U01) - PAR-12-095

What is the Basic Cancer Research in Cancer Health Disparities (U01) opportunity (PAR-12-095)?

PAR-12-095 was a National Institutes of Health (NIH) funding announcement led by the National Cancer Institute (NCI). It supported basic, mechanistic cancer research focused on understanding biological and genetic contributors to cancer health disparities.

Which NIH/NCI groups led or participated in this announcement?

The announcement was led by NCI, specifically involving the Center to Reduce Cancer Health Disparities (CRCHD), along with NCI's Division of Cancer Biology (DCB) and Division of Cancer Prevention (DCP).

What was the main purpose of this program?

The central purpose was to stimulate and support basic, mechanistic research that investigates biological and genetic drivers behind cancer health disparities. The focus was on explaining disparity-related differences at a fundamental level, not just describing unequal outcomes.

What types of disparity-related questions was the research expected to address?

The program aimed to support studies examining why certain populations experience differences in cancer risk, tumor behavior, responses to prevention strategies, or outcomes, where those differences are connected to underlying biologic or genetic factors.

What funding mechanism did this FOA use?

This FOA used the U01 cooperative agreement mechanism. Under a cooperative agreement, funded projects are expected to involve an active partnership with NIH/NCI program staff, rather than operating as fully independent investigator-initiated grants.

What does "cooperative agreement" imply for how projects are managed?

Based on the information provided, projects funded under the U01 mechanism were expected to include active involvement and partnership with NIH/NCI program staff during the conduct of the research.

What kinds of research activities were encouraged under PAR-12-095?

The FOA explicitly encouraged innovative research programs that clarify biological mechanisms contributing to disparities, including development or refinement of research tools. Examples mentioned include new methodologies, experimental models, mechanistic studies of previously identified factors, and secondary analyses of existing datasets when they can reveal biologic or genetic mechanisms.

Were projects focused on prevention allowed?

Yes. The FOA left room for basic research connected to prevention, as long as it stayed focused on mechanistic understanding relevant to disparity-related differences.

Did the program allow secondary analyses of existing data?

Yes. Secondary analyses of existing datasets were encouraged when those analyses could reveal biologic or genetic mechanisms relevant to cancer health disparities.

Was tool and resource development part of the program's goals?

Yes. In addition to producing scientific findings, the program emphasized creating shared resources and practical tools to make future disparity-focused basic research more feasible and rigorous.

What kinds of shared resources or tools were highlighted?

Examples mentioned include well-annotated biospecimen collections, cell lines, and validated methods and models tailored to studying disparity-associated biology.

Was capacity-building a major theme of the opportunity?

Yes. A major theme was strengthening the field by growing a nationwide cohort of scientists with strong basic research expertise specifically focused on cancer health disparities, while also building infrastructure and shared resources for long-term sustainability.

How was this opportunity categorized administratively?

It was described as a discretionary funding opportunity categorized under education and health-related research activity areas.

Which CFDA program listings did this FOA align with?

The announcement aligned with multiple NCI-related CFDA listings: 93.393 (Cancer Cause and Prevention Research), 93.396 (Cancer Biology Research), and 93.399 (Cancer Control).

Was cost-sharing or matching required?

No. The announcement indicated there was no cost-sharing or matching requirement.

What were the key dates for this funding opportunity?

The posting date and creation date were February 2, 2012. The original and current closing date were listed as November 20, 2014. The archive date was December 21, 2014.

What was the award ceiling listed for PAR-12-095?

The listed award ceiling was $250,000, described as an upper limit referenced in the source summary for funding levels under this announcement.

Who was eligible to apply?

Eligibility was broad and included public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3)), small businesses and other for-profit organizations (with small businesses explicitly called out), and multiple types of government entities (state, county, city/township, special district governments), as well as independent school districts and public housing authorities/Indian housing authorities.

Were minority-serving institutions and tribal entities specifically included?

Yes. The eligibility language emphasized inclusion of organizations often central to health disparity work, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian serving institutions, and other tribal organizations and governments (including federally recognized tribal governments).

Could non-U.S. organizations or foreign components apply?

Yes. The FOA allowed non-U.S. entities to apply, permitted non-U.S. components of U.S. organizations, and allowed foreign components as defined under NIH policy.

Where could applicants find the full FOA details?

The FOA was hosted through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PAR-12-095.html

Who should be contacted for access or technical issues with the FOA link?

The provided contact route for access or technical issues was the NIH Office of Extramural Research (OER) webmaster email: FBOWebmaster@OD.NIH.GOV

Is this opportunity still open?

No. The provided dates indicate the closing date was November 20, 2014, and the archive date was December 21, 2014.

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