Opportunity Information: Apply for PAR 12 094

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research.
  • This funding opportunity was created on Feb 2, 2012 and posted on Feb 2, 2012.
  • Applicants must submit their applications by Nov 20, 2014. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $200,000.00 in funding.
  • Eligible applicants include: County governments Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Native American tribal governments (Federally recognized) Small businesses Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts City or township governments For profit organizations other than small businesses Public and State controlled institutions of higher education Special district governments Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:

The Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21) is a National Institutes of Health (NIH), National Cancer Institute (NCI) funding opportunity designed to spark early stage, high impact basic science projects focused on why cancer outcomes differ across populations. Specifically, the program is sponsored through the NCI Center to Reduce Cancer Health Disparities (CRCHD) and the NCI Division of Cancer Biology (DCB), and it targets research that digs into biological, genetic, and mechanistic factors that may contribute to cancer health disparities. The emphasis is on basic research rather than clinical or purely social/behavioral work, with the goal of generating strong preliminary evidence and new approaches that can later be scaled into larger, R01 level studies.

This R21 mechanism is meant for exploratory and developmental work, so it supports projects such as pilot and feasibility studies, innovative mechanistic investigations, development and testing of new laboratory or analytic methods, and secondary analyses of existing datasets or biospecimen resources. In practice, that means applicants could propose smaller, tightly focused studies that test a novel hypothesis about molecular pathways, genetic variants, tumor biology, host factors, or other underlying mechanisms that might help explain disproportionate cancer incidence, aggressiveness, or mortality in particular groups. The program is also structured to encourage innovation, allowing investigators to take on ideas that may be too preliminary for larger grants but are important for building the evidence base needed to compete successfully for future R01 funding.

A key purpose of the opportunity is capacity building in the cancer disparities basic science workforce. Beyond funding individual projects, the FOA explicitly aims to help grow a nationwide community of scientists with strong expertise in mechanistic, biology driven cancer health disparities research. It is positioned as a stepping stone for investigators who need targeted resources and support to strengthen their research trajectory, publish foundational findings, develop tools, and establish the kind of preliminary data that typically underpins competitive R01 applications in basic cancer biology and disparities related mechanisms.

Administratively, this is a discretionary grant program under the NIH umbrella, listed under CFDA numbers 93.393 (Cancer Cause and Prevention Research) and 93.396 (Cancer Biology Research). The funding opportunity number is PAR-12-094, and the program carried an award ceiling of $200,000. There is no cost sharing or matching requirement, which is consistent with many NIH research grant mechanisms and can reduce barriers for organizations that might not have flexible institutional funds to contribute.

Eligibility is broad and includes a wide range of organizations. Eligible applicants include public and private institutions of higher education (including public/state controlled universities), nonprofits with or without 501(c)(3) status, state and local governments (including counties, cities/townships, special districts, and independent school districts), public housing authorities/Indian housing authorities, small businesses and other for-profit organizations (with small businesses explicitly listed), and Native American tribal governments and tribal organizations (both federally recognized and other than federally recognized). The FOA also calls out many institution types that are often central to training and research in underserved communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined under the NIH Grants Policy Statement, which creates room for international collaboration when it strengthens the science.

In terms of timing and status, the FOA was posted on February 2, 2012, and it originally closed on November 20, 2014, with an archive date of December 21, 2014. While it is archived as listed in the source data, it remains a useful reference point for understanding NCI priorities around biologically grounded cancer disparities research and the types of exploratory projects NCI has sought to seed through the R21 mechanism.

For applicants who wanted the full official requirements, submission instructions, and scientific scope language, the FOA pointed to the NIH Grants Guide posting at http://grants.nih.gov/grants/guide/pa-files/PAR-12-094.html, and the contact pathway for technical access issues was the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).

FAQs: Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21) - PAR-12-094

What is this grant opportunity?

This opportunity is the NIH National Cancer Institute (NCI) Exploratory/Developmental Grants Program for Basic Cancer Research in Cancer Health Disparities (R21). It is designed to spark early-stage, high-impact basic science projects focused on understanding why cancer outcomes differ across populations.

Which NIH institute and NCI components sponsor the program?

The program sits under the NIH umbrella and is offered by the National Cancer Institute (NCI). It is sponsored through the NCI Center to Reduce Cancer Health Disparities (CRCHD) and the NCI Division of Cancer Biology (DCB).

What kind of research does this FOA emphasize?

The emphasis is on basic, biology-driven research that investigates biological, genetic, and mechanistic factors that may contribute to cancer health disparities. The focus is on underlying mechanisms (for example, molecular pathways, genetic variants, tumor biology, and host factors) that could help explain disproportionate cancer incidence, aggressiveness, or mortality in particular groups.

Is this intended for clinical research or social/behavioral research?

Based on the provided description, the FOA emphasizes basic research rather than clinical research or purely social/behavioral work.

What does the R21 mechanism support in practice?

This R21 mechanism supports exploratory and developmental work. Examples described include pilot and feasibility studies, innovative mechanistic investigations, development and testing of new laboratory or analytic methods, and secondary analyses of existing datasets or biospecimen resources.

Why is this considered an exploratory or developmental award?

The opportunity is structured to encourage innovation and allow investigators to pursue ideas that may be too preliminary for larger grants. It is meant to help generate strong preliminary evidence and new approaches that can later be scaled into larger R01-level studies.

What is the long-term goal of projects funded under this FOA?

A major goal is to generate foundational findings, preliminary data, and new tools or methods that position investigators to compete successfully for future R01 funding in basic cancer biology and disparities-related mechanisms.

Does the FOA mention workforce or capacity-building goals?

Yes. In addition to funding individual projects, the FOA explicitly aims at capacity building in the cancer disparities basic science workforce by helping grow a nationwide community of scientists with expertise in mechanistic, biology-driven cancer health disparities research.

What is the funding opportunity number?

The funding opportunity number is PAR-12-094.

What is the award ceiling mentioned for this program?

The program carried an award ceiling of $200,000 (as stated in the provided information).

Is cost sharing or matching required?

No. The opportunity states there is no cost sharing or matching requirement.

Which CFDA numbers are associated with this program?

The program is listed under CFDA 93.393 (Cancer Cause and Prevention Research) and CFDA 93.396 (Cancer Biology Research).

What types of organizations are eligible to apply?

Eligibility is broad. Eligible applicants include public and private institutions of higher education, nonprofits (with or without 501(c)(3) status), state and local governments, public housing authorities/Indian housing authorities, small businesses and other for-profit organizations, and Native American tribal governments and tribal organizations (federally recognized and other than federally recognized).

Are specific institution types called out as eligible?

Yes. The FOA calls out institution types often central to training and research in underserved communities, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, regional organizations, and U.S. territories or possessions.

Can for-profit entities apply?

Yes. The eligibility list includes small businesses and other for-profit organizations, with small businesses explicitly listed.

Are foreign (non-U.S.) institutions eligible?

Yes. The provided information states that non-U.S. entities (foreign institutions) are eligible to apply.

Are non-U.S. components of U.S. organizations eligible?

Yes. Non-U.S. components of U.S. organizations are described as eligible.

Are foreign components allowed on applications?

Yes. Foreign components are allowed as defined under the NIH Grants Policy Statement, which can support international collaboration when it strengthens the science.

When was this FOA posted, and what is its current status?

The FOA was posted on February 2, 2012. It originally closed on November 20, 2014, and has an archive date of December 21, 2014. Based on the provided information, it is archived.

If it is archived, why might it still be useful?

Even though it is archived, it can still be a useful reference point for understanding NCI priorities around biologically grounded cancer disparities research and the types of exploratory projects NCI has sought to seed through the R21 mechanism.

Where can applicants find the official NIH Grants Guide posting for this FOA?

The FOA points to the NIH Grants Guide posting at: http://grants.nih.gov/grants/guide/pa-files/PAR-12-094.html

Who is the contact for technical access issues?

For technical access issues, the FOA lists the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.

What is the program trying to explain about cancer outcomes?

The program is focused on research into why cancer outcomes differ across populations, with an emphasis on biological, genetic, and mechanistic explanations that may contribute to disparities in incidence, aggressiveness, or mortality.

What types of study approaches are explicitly mentioned as suitable?

The description explicitly mentions pilot and feasibility studies, innovative mechanistic investigations, development and testing of new laboratory or analytic methods, and secondary analyses of existing datasets or biospecimen resources.

How does this FOA describe the role of innovation?

Innovation is encouraged by design. The FOA is positioned to let investigators pursue promising ideas that are still early and may not yet be ready for larger grants, while building the evidence base needed for future, larger-scale studies.

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Funding Number: PA 12 129
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Translational Research at the Aging/Cancer Interface (TRACI) (R21) Apply for PA 12 135

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Funding Number: PA 12 136
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Early Detection and Prevention of Mild Cognitive Impairment (R01) Apply for RFA NR 12 010

Funding Number: RFA NR 12 010
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Funding Number: PAS 12 122
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Funding Number: PA 12 117
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Technology Based Interventions to Promote Engagement in Care and Treatment Adherence and For Substance Abusing Populations with HIV (R34) Apply for PA 12 118

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