Behavioral and Integrative Treatment Development Program (R01) | Apply Online

Opportunity Summary:

The Behavioral and Integrative Treatment Development Program (R01) is a National Institutes of Health (NIH) funding opportunity designed to support research that meaningfully improves treatment for drug and alcohol abuse and dependence. The focus is on behavioral and integrative treatment development, meaning projects are expected to advance practical, evidence-based interventions that can improve real-world outcomes for people with substance use disorders. In general terms, this includes developing, refining, and testing treatment approaches that may involve behavioral therapies as well as integrative strategies that complement standard care, with the overarching goal of strengthening the effectiveness, accessibility, and impact of treatment.

This opportunity uses the NIH Research Project Grant (R01) mechanism, which is typically intended for more mature or larger-scope research projects that require substantial support and time to complete. The announcement notes that it runs in parallel with two related NIH opportunities of the same scientific scope but different grant mechanisms: an Exploratory/Developmental Grant (R21) and a Small Research Grant (R03). In practice, that means investigators should choose the mechanism that best fits the stage and scale of their work, with the R01 serving as the main pathway for full research projects, while the R21 and R03 options exist for earlier-stage or smaller, targeted studies.

Funding levels and the number of awards are not fixed in advance. Instead, NIH anticipates that award size and project duration will vary depending on what applicants propose, since the nature and scope of behavioral and integrative treatment research can differ widely across studies. As a result, the total dollars awarded and the number of funded projects depend on several factors at the time of review and selection, including the number of applications received, their scientific and technical quality, the requested budgets, and the proposed project periods.

The opportunity is listed as discretionary and uses a grant funding instrument. It aligns with federal assistance listings that include complementary and integrative health research and drug abuse and addiction research programs (CFDA 93.213 and 93.279). There is no cost sharing or matching requirement, so applicants are not required to provide non-federal matching funds as a condition of eligibility.

Eligibility is broad and includes many types of domestic organizations and governments, such as state and local governments (including counties, cities, townships, and special districts), public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status, with exceptions noted for institutions of higher education), for-profit organizations (including small businesses and other for-profits), independent school districts, and public housing authorities/Indian housing authorities. The announcement also explicitly states that foreign institutions are eligible to apply, eligible federal government agencies may apply, and faith-based or community-based organizations may apply, which widens participation beyond the traditional academic and medical research settings.

Key administrative details include the funding opportunity number PA 07 111 and an original posting date of December 7, 2006, with the record indicating multiple receipt dates rather than a single deadline. The current closing date shown is September 7, 2009, with an archive date of October 7, 2009, reflecting that this particular announcement is no longer active but remains relevant as a reference point for the program’s intent and structure. The full announcement was available through the NIH grants website, and NIH provided contact support through the NIH Office of Extramural Research (OER) webmaster for access or linking issues.

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Next opportunity: Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R01)

Previous opportunity: Research on Rural Mental Health and Drug Abuse Disorders (R01)

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