Opportunity Information: Apply for RFA MH 11 090

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Behavioral Mechanisms in Biomedical Strategies to Prevent HIV Infections (R01)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
  • This funding opportunity was created on Aug 17, 2010 and posted on Aug 17, 2010.
  • Applicants must submit their applications by Jan 4, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $500,000.00 in funding.
  • Eligible applicants include: Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education State governments Native American tribal governments (Federally recognized) For profit organizations other than small businesses City or township governments Special district governments County governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Public and State controlled institutions of higher education Independent school districts.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Behavioral Mechanisms in Biomedical Strategies to Prevent HIV Infections (R01) opportunity (Funding Opportunity Number RFA-MH-11-090) was a discretionary NIH grant announcement led by the National Institute of Mental Health (NIMH). Its central goal was to fund research that explains why promising biomedical HIV prevention tools do not always perform the same way in real-world settings as they do under controlled clinical conditions. In plain terms, the FOA focused on the behavioral and social "mechanisms" that shape whether biomedical prevention strategies actually get used correctly, consistently, and effectively, and how factors like relationships, stigma, adherence, risk perception, social networks, and structural barriers can strengthen or weaken the impact of biomedical approaches designed to reduce HIV transmission.

This FOA used the NIH Research Project Grant (R01) mechanism, which generally supports mature, hypothesis-driven projects with substantial scope and a clear research plan. It was issued alongside two companion announcements with the same scientific focus but different grant mechanisms: an R21 version (RFA-MH-11-091) intended for exploratory or early-stage work, and an R34 version (RFA-MH-11-092) intended for early phases of treatment development. The R01 described here was therefore aimed at more developed projects ready for a full-scale research study, rather than purely pilot or early development efforts.

NIMH indicated it planned to commit about $2,000,000 in FY 2011 across this FOA and its companion announcements, with an expectation of making roughly four to six total awards. The listed award ceiling was $500,000, and the program did not require cost sharing or matching funds. The assistance listing associated with the opportunity was CFDA 93.242 (Mental Health Research Grants), emphasizing that the behavioral science component and mental health-related determinants of prevention success were a core interest, even though the topic area is HIV prevention.

Eligibility was broad and included a wide range of applicant types across the public, private, nonprofit, and academic sectors. Eligible applicants included public and private institutions of higher education, nonprofit organizations (both with and without 501(c)(3) status), for-profit organizations (other than small businesses) as well as small businesses, and multiple levels of government (state, county, city/township, special district). The FOA also explicitly included tribal governments and tribal organizations, public and Indian housing authorities, independent school districts, and a variety of mission-focused or designated institutions and entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs). It also allowed non-U.S. (foreign) organizations, regional organizations, U.S. territories or possessions, federal agencies, and faith-based or community-based organizations, reflecting an intent to support work that could be conducted in diverse geographic and organizational contexts, including global settings where HIV prevention implementation questions are often pressing.

Administratively, the opportunity was posted and created on Aug 17, 2010, with an original and current closing date of Jan 4, 2011, and an archive date of Feb 4, 2011. The official full announcement was hosted through the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-11-090.html). For technical access issues, the contact listed was the NIH Office of Extramural Research webmaster (FBOWebmaster@OD.NIH.GOV).

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled Behavioral Mechanisms in Biomedical Strategies to Prevent HIV Infections (R01).

What is the Funding Opportunity Number (FOA number)?

The Funding Opportunity Number is RFA-MH-11-090.

Which agency and institute led this announcement?

This was a discretionary NIH funding announcement led by the National Institute of Mental Health (NIMH).

What is the main purpose of this FOA?

The FOA aimed to fund research that explains why promising biomedical HIV prevention tools may not perform the same way in real-world settings as they do in controlled clinical conditions. The focus was on identifying and testing behavioral and social mechanisms that influence whether biomedical prevention strategies are used correctly, consistently, and effectively.

What does "behavioral mechanisms" mean in the context of this FOA?

In this FOA, behavioral and social "mechanisms" refer to the factors and pathways that shape real-world use and impact of biomedical HIV prevention strategies, including influences such as relationships, stigma, adherence, risk perception, social networks, and structural barriers.

What kind of research projects was this FOA trying to support?

The FOA emphasized research on how behavioral and social determinants can strengthen or weaken the effectiveness of biomedical approaches designed to reduce HIV transmission, particularly in real-world implementation contexts.

What grant mechanism does this opportunity use?

This opportunity used the NIH Research Project Grant (R01) mechanism.

What does it mean that this is an R01 opportunity?

The R01 mechanism generally supports more mature, hypothesis-driven projects with substantial scope and a clear, full research plan. In this FOA, the R01 was positioned for projects ready for full-scale research, rather than purely pilot studies or early development efforts.

Were there companion announcements related to this FOA?

Yes. The R01 announcement was issued alongside two companion announcements with the same scientific focus but different mechanisms: an R21 version (RFA-MH-11-091) intended for exploratory or early-stage work, and an R34 version (RFA-MH-11-092) intended for early phases of treatment development.

How much funding did NIMH plan to commit, and how many awards were expected?

NIMH indicated it planned to commit about $2,000,000 in FY 2011 across this FOA and its companion announcements, with an expectation of making roughly four to six total awards.

What was the maximum award amount listed for this opportunity?

The listed award ceiling was $500,000.

Was cost sharing or matching required?

No. The program did not require cost sharing or matching funds.

What is the Assistance Listing (CFDA) number for this opportunity?

The associated Assistance Listing was CFDA 93.242, labeled Mental Health Research Grants.

Why is a mental health research listing associated with an HIV prevention FOA?

The CFDA listing underscores that behavioral science and mental health-related determinants of prevention success were a core interest for this opportunity, even though the overall topic area is HIV prevention.

Who was eligible to apply?

Eligibility was broad and included many public, private, nonprofit, and academic sectors, as well as government entities and other organizational types explicitly named in the FOA.

Are institutions of higher education eligible?

Yes. Eligible applicants included public and private institutions of higher education.

Are nonprofit organizations eligible to apply?

Yes. Eligible applicants included nonprofit organizations with or without 501(c)(3) status.

Are for-profit organizations eligible to apply?

Yes. Eligible applicants included for-profit organizations (other than small businesses) and also small businesses.

Are government entities eligible to apply?

Yes. Eligibility included multiple levels of government such as state, county, city/township, and special district governments, as well as federal agencies.

Are tribal governments and tribal organizations eligible?

Yes. The FOA explicitly included tribal governments and tribal organizations.

Are U.S. territories or possessions eligible?

Yes. The eligibility list included U.S. territories or possessions.

Can non-U.S. (foreign) organizations apply?

Yes. The FOA allowed non-U.S. (foreign) organizations and also included regional organizations, reflecting an intent to support work in diverse geographic contexts, including global settings.

Are faith-based and community-based organizations eligible?

Yes. The FOA included faith-based and community-based organizations among eligible applicant types.

Are housing authorities and school districts eligible?

Yes. The FOA explicitly included public and Indian housing authorities and independent school districts.

Did the FOA highlight eligibility for mission-focused or designated institutions?

Yes. The eligibility list explicitly included institutions and entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).

When was this opportunity posted?

The opportunity was posted and created on Aug 17, 2010.

What was the application closing date?

The original and current closing date listed was Jan 4, 2011.

When was the opportunity archived?

The archive date was Feb 4, 2011.

Where can applicants find the official full announcement?

The official announcement was hosted in the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-MH-11-090.html.

Who should be contacted for technical access issues?

For technical access issues, the listed contact was the NIH Office of Extramural Research webmaster at FBOWebmaster@OD.NIH.GOV.

Is this opportunity focused more on clinical efficacy or real-world implementation?

Based on the description provided, the FOA was centered on understanding why results may differ between controlled clinical conditions and real-world settings, with particular attention to behavioral and social factors that influence real-world use and effectiveness.

Does this FOA focus only on biomedical tools?

No. While the prevention approaches are biomedical, the FOA specifically targeted the behavioral and social mechanisms that shape how those biomedical strategies are adopted, adhered to, and ultimately how effective they are in practice.

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