Opportunity Information: Apply for RFA MH 11 092

  • The National Institutes of Health in the health sector is offering a public funding opportunity titled "Behavioral Mechanisms in Biomedical Strategies to Prevent HIV Infections (R34)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants.
  • This funding opportunity was created on Aug 17, 2010 and posted on Aug 17, 2010.
  • Applicants must submit their applications by Jan 4, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $2,000,000.00 to eligible and selected applicants.
  • Each selected applicant is eligible to receive up to $225,000.00 in funding.
  • Eligible applicants include: Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Special district governments Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Small businesses Private institutions of higher education Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses State governments.
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
Apply for RFA MH 11 092

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Opportunity Summary:

The Behavioral Mechanisms in Biomedical Strategies to Prevent HIV Infections (R34) grant opportunity (Funding Opportunity Number RFA-MH-11-092) was a discretionary research grant issued by the National Institutes of Health, specifically through the National Institute of Mental Health (NIMH). Its main goal was to support studies that dig into the behavioral and social factors that can influence how well new biomedical HIV prevention strategies work in real-world settings. In practical terms, the FOA recognized that even highly promising biomedical tools to prevent HIV can fall short if people cannot, will not, or do not consistently use them as intended, or if social environments and structural barriers make use difficult. The focus, therefore, was on improving understanding of those human, interpersonal, and community-level mechanisms that shape uptake, adherence, persistence, risk behavior changes, partner dynamics, stigma, access, and other contextual drivers that ultimately affect prevention outcomes.

This announcement used the NIMH R34 mechanism, which is typically intended for clinical trial planning and early-stage preparatory work. In the context of HIV prevention, the R34 mechanism generally fits projects aimed at piloting or refining research approaches, developing or adapting behavioral measures, testing recruitment and retention strategies, building intervention components that align with biomedical prevention, and assembling the groundwork needed for later, larger-scale efficacy or effectiveness trials. The FOA also noted that it ran in parallel with two companion announcements that shared the same scientific scope but offered different activity codes: MH-11-090 for the R01 mechanism and MH-11-091 for the R21 mechanism. That structure allowed applicants to choose a mechanism that matched the maturity and scale of their proposed work, while keeping the central scientific theme consistent across the set.

Funding for this initiative was projected at about $2,000,000 in fiscal year 2011, with an expectation of making roughly four to six awards across this FOA and its companion FOAs combined. For the R34 specifically, the listed award ceiling was $225,000. There was no cost sharing or matching requirement, which meant applicants were not required to provide non-federal funds to receive an award. The opportunity was posted on August 17, 2010, with an original and current closing date of January 4, 2011, and it was later archived on February 4, 2011. The CFDA number associated with it was 93.242 (Mental Health Research Grants), reflecting its placement within NIMH and its emphasis on behavioral and social science as essential components of HIV prevention science.

Eligibility was broad and included many types of organizations that might be positioned to conduct behavioral, clinical, community-based, or implementation-oriented HIV prevention research. Eligible applicants included public and private institutions of higher education, nonprofits (including those with and without 501(c)(3) status), small businesses, for-profit organizations other than small businesses, and multiple levels of government (state, county, city/township, special district, and independent school districts). The FOA also explicitly included a range of institutions and communities often central to HIV prevention work, such as federally recognized and other tribal governments and organizations, tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and even non-U.S. entities (foreign organizations). Federal agencies were also listed as eligible, reflecting NIH policies that can allow certain federal components to apply under specific circumstances.

Overall, the grant opportunity can be summarized as an effort by NIMH to make biomedical HIV prevention research more realistic and more effective by taking behavior and social context seriously, not as side issues but as core determinants of outcomes. Rather than focusing on inventing a new biomedical product, the FOA emphasized the real-world pathways through which biomedical prevention succeeds or fails: what people believe, what they fear, what resources they can access, how relationships and communities shape decision-making, and how social and structural pressures influence consistent engagement with prevention methods. Applicants were directed to the full announcement for details via the NIH grants guide link provided in the notice, and technical issues were routed to the NIH Office of Extramural Research (OER) webmaster contact.

Frequently Asked Questions (FAQs)

What is the name of this grant opportunity?

The opportunity is titled Behavioral Mechanisms in Biomedical Strategies to Prevent HIV Infections (R34).

What is the Funding Opportunity Number (FON)?

The Funding Opportunity Number is RFA-MH-11-092.

Which agency and institute issued this funding opportunity?

This was a discretionary research grant issued by the National Institutes of Health (NIH), specifically through the National Institute of Mental Health (NIMH).

What is the main purpose of this FOA?

The main goal was to support studies examining the behavioral and social factors that influence how well biomedical HIV prevention strategies work in real-world settings.

Why does this FOA focus on behavioral and social factors if the prevention strategies are biomedical?

The FOA recognized that biomedical tools can underperform if people do not or cannot use them consistently or correctly, or if social and structural barriers make use difficult. The emphasis is on the human and contextual mechanisms that determine whether prevention succeeds in practice.

What kinds of mechanisms or factors were within scope?

The opportunity emphasized mechanisms and contextual drivers such as uptake, adherence, persistence, risk behavior changes, partner dynamics, stigma, access, and other interpersonal, community-level, and structural influences affecting prevention outcomes.

What grant mechanism does this announcement use?

This announcement used the NIMH R34 mechanism.

What is the R34 mechanism generally intended for in this context?

In this HIV prevention context, the R34 generally fits clinical trial planning and early-stage preparatory work, such as piloting or refining research approaches, developing or adapting behavioral measures, testing recruitment and retention strategies, building intervention components aligned with biomedical prevention, and laying the groundwork for later, larger-scale trials.

Does this FOA fund development of new biomedical HIV prevention products?

Based on the description provided, the emphasis was not on inventing a new biomedical product, but on understanding the real-world behavioral and social pathways through which biomedical prevention succeeds or fails.

Were there companion funding announcements related to this FOA?

Yes. This FOA ran in parallel with two companion announcements with the same scientific scope but different activity codes: MH-11-090 (R01) and MH-11-091 (R21).

How were applicants expected to choose between the R34 and the companion mechanisms?

The structure was designed so applicants could select a mechanism that matched the maturity and scale of their proposed work while keeping the central scientific theme consistent across the set.

How much funding was projected for this initiative?

Funding for the initiative was projected at about $2,000,000 in fiscal year 2011.

How many awards were expected?

Across this FOA and its companion FOAs combined, the expectation was roughly four to six awards.

What was the award ceiling for the R34 under this FOA?

For the R34 specifically, the listed award ceiling was $225,000.

Was cost sharing or matching required?

No. There was no cost sharing or matching requirement, so applicants were not required to provide non-federal funds to receive an award.

When was this opportunity posted?

The opportunity was posted on August 17, 2010.

What was the closing date?

The original and current closing date was January 4, 2011.

Is this funding opportunity still active?

No. It was later archived on February 4, 2011.

What CFDA number is associated with this opportunity?

The CFDA number associated with this FOA is 93.242, titled Mental Health Research Grants.

Who was eligible to apply?

Eligibility was broad and included many organization types, including: public and private institutions of higher education; nonprofits (with or without 501(c)(3) status); small businesses; for-profit organizations other than small businesses; and multiple levels of government (state, county, city/township, special district, and independent school districts).

Were tribal governments and tribal organizations eligible?

Yes. The FOA explicitly included federally recognized and other tribal governments and organizations, as well as tribally controlled colleges and universities.

Were minority-serving institutions and community organizations included in eligibility?

Yes. The FOA explicitly included institutions and organizations often central to HIV prevention work, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian Serving Institutions, faith-based and community-based organizations, and regional organizations.

Could organizations in U.S. territories apply?

Yes. The FOA included U.S. territories or possessions among eligible applicants.

Were foreign (non-U.S.) organizations eligible to apply?

Yes. The FOA explicitly stated that non-U.S. entities (foreign organizations) were eligible.

Were federal agencies eligible to apply?

Yes. Federal agencies were listed as eligible, reflecting NIH policies that can allow certain federal components to apply under specific circumstances.

What is the overall takeaway of this opportunity in plain terms?

It was an NIMH effort to make biomedical HIV prevention research more realistic and effective by treating behavior and social context as core determinants of outcomes, focusing on what people do, what barriers they face, and how relationships and communities shape consistent engagement with prevention methods.

Where were applicants directed for full details and official instructions?

Applicants were directed to the full announcement in the NIH grants guide link provided in the notice.

Where were technical issues routed?

Technical issues were routed to the NIH Office of Extramural Research (OER) webmaster contact.

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