Opportunity Information: Apply for PA 15 015
Apply for PA 15 015
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Biobehavioral and Technological Interventions to Attenuate Cognitive Decline in Individuals with Cognitive Impairment or Dementia (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.866 Aging Research.
- This funding opportunity was created on Oct 14, 2014 and posted on Oct 14, 2014.
- Applicants must submit their applications by Jan 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Independent school districts For profit organizations other than small businesses Special district governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) State governments Native American tribal organizations (other than Federally recognized tribal governments) Public housing authorities/Indian housing authorities City or township governments Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The grant opportunity titled "Biobehavioral and Technological Interventions to Attenuate Cognitive Decline in Individuals with Cognitive Impairment or Dementia (R21)" (Funding Opportunity Number PA 15-015) is a National Institutes of Health (NIH) discretionary grant aimed at sparking early-stage clinical research on practical ways to slow or reduce cognitive decline. It focuses on people living with dementia (including Alzheimer's disease, Lewy body dementia, and vascular dementia), mild cognitive impairment (MCI), and cognitive decline tied to aging or disease. The central idea is to support innovative, exploratory projects that test or refine interventions designed to preserve thinking abilities and day-to-day functioning for as long as possible.
A key emphasis of this FOA is on biobehavioral and technological interventions. Biobehavioral approaches can include strategies that combine behavioral change, psychosocial support, and health-related routines that may influence cognition or coping, while technological interventions may involve tools or platforms that help monitor, train, assist, or support cognition and function. The announcement highlights particular interest in interventions that can realistically be used in community settings rather than only in specialized clinics. That includes interventions delivered or carried out by the affected individual, informal caregivers (such as family members), or other community members and organizations. In other words, projects that can work in real-world living environments, and not just in tightly controlled research settings, align strongly with the intent of this funding.
Beyond testing an intervention itself, the FOA also welcomes research that informs intervention development. This includes preparatory or foundational studies that help design, optimize, adapt, or tailor interventions for people with cognitive impairment or dementia. It also supports work that investigates why an intervention works (or does not work) by examining underlying mechanisms and biomarkers linked to response. That could mean identifying measurable biological or behavioral indicators associated with improvement, stability, or slower decline, helping researchers better understand which subgroups benefit and how future interventions might be targeted more effectively.
The anticipated impact described in the announcement is broad and patient- and caregiver-centered. NIH expects supported projects to generate findings that help individuals maintain independence and quality of life, including stronger ability to manage activities of daily living (ADLs) like bathing, dressing, and eating, and instrumental activities of daily living (IADLs) like managing medications, handling finances, preparing meals, transportation, and other tasks required for independent living. The FOA also explicitly recognizes the caregiver dimension of cognitive impairment and dementia, aiming for outcomes that reduce caregiver stress, burden, and related negative health and social consequences. In practical terms, this means projects that improve the daily experience of both the individual and the caregiver, such as reducing crises, improving routines, supporting safer home living, or easing supervisory demands, are consistent with the goals of the program.
This is an R21 mechanism, which is typically used by NIH to support exploratory and developmental research rather than large-scale definitive trials. The listed award ceiling is $275,000, and the FOA states there is no cost sharing or matching requirement. The funding activity categories connected to this opportunity include health and education, and it is associated with CFDA numbers 93.361 (Nursing Research) and 93.866 (Aging Research), signaling that projects may be relevant to multiple research communities focused on aging, caregiving, clinical intervention development, and supportive care.
Eligibility is broad and includes many types of applicants across public, private, nonprofit, and for-profit sectors. Eligible applicants include state and local governments (including county and city/township governments), special district governments, public housing authorities/Indian housing authorities, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, small businesses, and other for-profit organizations that are not small businesses. The FOA also includes nonprofits with and without 501(c)(3) status. Additional eligible applicants explicitly include faith-based and community-based organizations, a range of minority-serving institutions (such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities), federally recognized tribal governments and other tribal organizations, and certain eligible federal agencies. Notably, non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations are eligible, and foreign components are allowed as defined by NIH policy, which makes this opportunity open to international participation where appropriate.
The FOA was posted on October 14, 2014, with an original and current closing date listed as January 7, 2018, and an archive date of February 7, 2018, meaning the opportunity as shown is historical rather than currently open. The full announcement was hosted through the NIH grants guide at the provided link (http://grants.nih.gov/grants/guide/pa-files/PA-15-015.html). For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV), reflecting that the contact is oriented to access and linking problems rather than scientific questions about project fit.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Biobehavioral and Technological Interventions to Attenuate Cognitive Decline in Individuals with Cognitive Impairment or Dementia (R21)" and the Funding Opportunity Number is PA 15-015.
Which agency is offering this grant opportunity?
This is a discretionary grant opportunity from the National Institutes of Health (NIH).
What is the overall purpose of this funding opportunity?
The goal is to spark early-stage clinical research on practical, innovative ways to slow or reduce cognitive decline, with an emphasis on preserving thinking abilities and day-to-day functioning for as long as possible.
What populations are the focus of this FOA?
The FOA focuses on individuals living with dementia (including Alzheimer's disease, Lewy body dementia, and vascular dementia), mild cognitive impairment (MCI), and cognitive decline tied to aging or disease.
What types of interventions are emphasized?
The FOA emphasizes biobehavioral and technological interventions. Biobehavioral approaches may combine behavioral change strategies, psychosocial support, and health-related routines. Technological interventions may involve tools or platforms that monitor, train, assist, or support cognition and function.
Is the FOA interested in interventions that can be used outside specialized clinics?
Yes. A key interest is interventions that can realistically be used in community settings and real-world living environments, not only in tightly controlled research settings or specialized clinics.
Who can deliver or carry out the interventions supported by this FOA?
The FOA highlights interventions that can be delivered or carried out by the affected individual, informal caregivers (such as family members), or other community members and organizations.
Does this funding opportunity support studies beyond testing an intervention?
Yes. The FOA also welcomes foundational or preparatory research that informs intervention development, such as studies to design, optimize, adapt, or tailor interventions for people with cognitive impairment or dementia.
Are studies on mechanisms or biomarkers within scope?
Yes. The FOA supports work that investigates why an intervention works (or does not work) by examining underlying mechanisms and biomarkers linked to intervention response, including measurable biological or behavioral indicators associated with improvement, stability, or slower decline.
What outcomes or impacts is NIH aiming for?
NIH anticipates projects will generate findings that help individuals maintain independence and quality of life. The FOA specifically mentions outcomes related to activities of daily living (ADLs) and instrumental activities of daily living (IADLs), as well as outcomes that reduce caregiver stress and burden.
What are examples of daily functioning areas mentioned in the FOA?
The FOA references ADLs such as bathing, dressing, and eating, and IADLs such as managing medications, handling finances, preparing meals, transportation, and other tasks required for independent living.
How does this FOA address caregivers?
The FOA explicitly recognizes the caregiver dimension of cognitive impairment and dementia and supports outcomes that reduce caregiver stress, burden, and related negative health and social consequences. Projects that improve daily experiences for both the individual and the caregiver (for example, improving routines or easing supervisory demands) align with the program goals.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R21 mechanism, which is typically intended for exploratory and developmental research rather than large-scale definitive trials.
What is the maximum award amount listed?
The listed award ceiling is $275,000.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
What are the related funding activity categories?
The funding activity categories connected to this opportunity include health and education.
Which CFDA numbers are associated with this FOA?
The FOA is associated with CFDA 93.361 (Nursing Research) and 93.866 (Aging Research).
Who is eligible to apply?
Eligibility is broad and includes many applicant types across public, private, nonprofit, and for-profit sectors. Examples listed include state and local governments (including county and city/township governments), special district governments, public housing authorities/Indian housing authorities, independent school districts, public and state-controlled institutions of higher education, private institutions of higher education, small businesses, other for-profit organizations (not small businesses), and nonprofits with and without 501(c)(3) status.
Are faith-based and community-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations among eligible applicants.
Are minority-serving institutions included in eligibility?
Yes. The FOA explicitly includes a range of minority-serving institutions such as HBCUs, Hispanic-serving institutions, AANAPISIs, Alaska Native and Native Hawaiian Serving Institutions, and tribally controlled colleges and universities.
Are tribal governments or tribal organizations eligible?
Yes. Federally recognized tribal governments and other tribal organizations are listed as eligible applicants.
Can non-U.S. (foreign) organizations apply?
Yes. The FOA states that non-U.S. entities (foreign organizations and foreign institutions) are eligible to apply. It also indicates that non-U.S. components of U.S. organizations are eligible and that foreign components are allowed as defined by NIH policy.
Is this opportunity currently open?
No. The FOA information shown is historical. It lists a closing date of January 7, 2018 and an archive date of February 7, 2018.
When was the FOA posted?
The FOA was posted on October 14, 2014.
Where can the full FOA be found?
The full announcement is hosted in the NIH grants guide at: http://grants.nih.gov/grants/guide/pa-files/PA-15-015.html
Who should be contacted for technical issues accessing the announcement?
For technical issues accessing the announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV. The listing indicates this contact is for access and linking problems rather than scientific or programmatic fit questions.
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Previous opportunity: 2015 NOAA California Bay Watershed Education and Training (B WET) Program
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| Funding Opportunity |
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| Biobehavioral and Technological Interventions to Attenuate Cognitive Decline in Individuals with Cognitive Impairment or Dementia (R01) Apply for PA 15 017 Funding Number: PA 15 017 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Biobehavioral and Technological Interventions to Attenuate Cognitive Decline in Individuals with Cognitive Impairment or Dementia (R15) Apply for PA 15 016 Funding Number: PA 15 016 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| Limited Competition for the Continuation of Rare Diseases Clinical Research Consortia in the Rare Diseases Clinical Research Network (U54) Apply for PAR 15 019 Funding Number: PAR 15 019 Agency: National Institutes of Health Category: Education Health Funding Amount: $1,250,000 |
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| Mechanistic Studies of Pain and Alcohol Dependence (R01) Apply for PA 15 026 Funding Number: PA 15 026 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Promoting Research in Basic Neuroscience (R01) Apply for PAS 15 029 Funding Number: PAS 15 029 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Early Detection Research Network Biomarker Developmental Laboratories (U01) Apply for RFA CA 14 014 Funding Number: RFA CA 14 014 Agency: National Institutes of Health Category: Education Health Funding Amount: $400,000 |
| The Early Detection Research Network Clinical Validation Centers (U01) Apply for RFA CA 14 015 Funding Number: RFA CA 14 015 Agency: National Institutes of Health Category: Education Health Funding Amount: $600,000 |
| The Early Detection Research Network Biomarker Reference Laboratories (U24) Apply for RFA CA 14 016 Funding Number: RFA CA 14 016 Agency: National Institutes of Health Category: Education Health Funding Amount: $300,000 |
| The Early Detection Research Network Data Management and Coordinating Center (U24) Apply for RFA CA 14 017 Funding Number: RFA CA 14 017 Agency: National Institutes of Health Category: Education Health Funding Amount: $4,500,000 |
| Cancer Prevention, Control, Behavioral Sciences, and Population Sciences Career Development Award (K07) Apply for PAR 15 033 Funding Number: PAR 15 033 Agency: National Institutes of Health Category: Education Health Funding Amount: $130,000 |
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| NCI Mentored Clinical Scientist Research Career Development Award to Promote Diversity (K08) Apply for PAR 15 060 Funding Number: PAR 15 060 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Mentored Patient Oriented Research Career Development Award to Promote Diversity (K23) Apply for PAR 15 062 Funding Number: PAR 15 062 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Transition Career Development Award to Promote Diversity (K22) Apply for PAR 15 063 Funding Number: PAR 15 063 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| NCI Mentored Research Scientist Development Award to Promote Diversity (K01) Apply for PAR 15 064 Funding Number: PAR 15 064 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The NCI Transition Career Development Award (K22) Apply for PAR 15 056 Funding Number: PAR 15 056 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
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