Opportunity Information: Apply for PA 10 150
Apply for PA 10 150
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Bioengineering Nanotechnology Initiative (SBIR R43/R44)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research 93.172 Human Genome Research 93.173 Research Related to Deafness and Communication Disorders 93.233 National Center on Sleep Disorders Research 93.242 Mental Health Research Grants 93.279 Drug Abuse and Addiction Research Programs 93.281 Mental Health Research Career/Scientist Development Awards 93.282 Mental Health National Research Service Awards for Research Training 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.846 Arthritis, Musculoskeletal and Skin Diseases Research 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Apr 6, 2010 and posted on Apr 6, 2010.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Small businesses.
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Opportunity Summary:
The Bioengineering Nanotechnology Initiative (SBIR R43/R44), Funding Opportunity Number PA 10 150, was a National Institutes of Health (NIH) trans-NIH funding opportunity designed to push forward practical, commercially oriented health technologies that rely on nanotechnology. In this context, nanotechnology is defined in the classic NIH/NNI sense as the ability to understand and control matter at roughly 1 to 100 nanometers, a size range where materials and devices can behave differently than they do at larger scales. The opportunity focused on using those nanoscale properties and tools (such as imaging, measuring, modeling, and manipulating matter at the nanoscale) to create new or improved diagnostics and therapeutic interventions for diseases, meaning it was aimed at tangible products and platforms rather than basic nanoscience alone.
This announcement used the Small Business Innovation Research (SBIR) grant mechanisms, specifically R43/R44, and supported Phase I, Phase II, and Fast Track applications. Phase I typically centers on early feasibility and proof-of-concept work, Phase II supports more advanced development and validation toward a product, and Fast Track allows applicants to propose a streamlined Phase I-to-Phase II path under a single combined submission. The FOA also ran in parallel with an equivalent-scoped opportunity for the Small Business Technology Transfer (STTR) program (PA 10 149; R41/R42), which is relevant for applicants deciding whether their project is better positioned as SBIR (small business-led R&D, with subcontracting allowed) or STTR (formally requiring collaboration with a nonprofit research institution).
Eligibility was limited to small businesses, consistent with SBIR rules, and there was no cost sharing or matching requirement. The funding instrument type was a discretionary grant, and the participating NIH ecosystem spanned multiple program areas, reflected in the wide list of CFDA numbers associated with institutes and topics such as oral health, genomics, deafness and communication disorders, sleep disorders, mental health, substance abuse, technological innovations for human health, arthritis and skin diseases, child health and development, aging, and vision research. Practically, that breadth signaled that nanoscale-enabled diagnostics and interventions could be relevant across many NIH missions, and that proposals might fit within many disease areas as long as the core innovation depended meaningfully on nanotechnology and aimed at improving detection, monitoring, or treatment.
In terms of award size and volume, NIH did not commit to a fixed number of awards or a set pool of money within the text provided. Instead, awards were explicitly contingent on annual appropriations, availability of funds, and the submission of a sufficient number of high-quality, meritorious applications. The actual amounts and number of awards were expected to vary based on the quality of applications and practical factors like the proposed project duration and budget.
Administratively, the opportunity was posted and created on April 6, 2010, with an original and final closing date of May 7, 2013, and it was archived on June 7, 2013. The official NIH program page was listed at http://grants.nih.gov/grants/guide/pa-files/PA-10-150.html, and NIH Office of Extramural Research (OER) webmaster contact emails were provided for access or linking issues. Overall, the grant opportunity was meant to accelerate early-stage and mid-stage commercialization-focused R&D in nanoscale biomedical technologies, helping small businesses translate nanotechnology concepts into real diagnostic tools and therapeutic approaches that could ultimately be deployed in clinical care.
Frequently Asked Questions (FAQs): Bioengineering Nanotechnology Initiative (SBIR R43/R44) - PA-10-150
What is the Bioengineering Nanotechnology Initiative (SBIR R43/R44) funding opportunity?
It is a National Institutes of Health (NIH) trans-NIH Small Business Innovation Research (SBIR) funding opportunity (Funding Opportunity Number PA 10 150) intended to advance practical, commercially oriented health technologies that rely on nanotechnology. The emphasis is on developing tangible diagnostics and therapeutic interventions rather than conducting basic nanoscience alone.
Which grant mechanisms are used under this opportunity?
This announcement uses the SBIR grant mechanisms R43 (Phase I) and R44 (Phase II). It supports Phase I applications, Phase II applications, and Fast Track applications that combine Phase I and Phase II into a single submission.
What does NIH mean by "nanotechnology" in this FOA?
Nanotechnology is defined in the classic NIH/NNI sense as the ability to understand and control matter at roughly 1 to 100 nanometers, where materials and devices can behave differently than at larger scales. The FOA focuses on using those nanoscale properties and related tools (such as imaging, measuring, modeling, and manipulating matter at the nanoscale) to create or improve biomedical technologies.
What kinds of projects is this FOA designed to support?
The opportunity is designed to support development of new or improved diagnostics and therapeutic interventions for diseases that meaningfully depend on nanotechnology. The intent is commercialization-focused R&D aimed at real products or platforms for detection, monitoring, or treatment, not basic nanoscience by itself.
What is the difference between Phase I, Phase II, and Fast Track under this SBIR opportunity?
Phase I typically focuses on early feasibility and proof-of-concept work. Phase II supports more advanced development and validation toward a product. Fast Track allows applicants to propose a streamlined Phase I-to-Phase II path by submitting a single, combined application covering both phases.
Who is eligible to apply?
Eligibility is limited to small businesses, consistent with SBIR program rules.
Is cost sharing or matching required?
No. The FOA explicitly indicates there is no cost sharing or matching requirement.
What is the funding instrument type for this opportunity?
The funding instrument type is a discretionary grant.
Does NIH specify a fixed total funding amount or a set number of awards?
No. The text provided does not commit to a fixed number of awards or a set pool of money. Awards are contingent on annual appropriations, availability of funds, and the receipt of a sufficient number of high-quality, meritorious applications.
What factors influence the actual award amounts and number of awards made?
The actual amounts and number of awards are expected to vary based on the quality of applications and practical factors such as proposed project duration and budget, along with available funds and appropriations.
Is this opportunity limited to a specific disease area or NIH institute?
No. It is described as trans-NIH and tied to a broad set of program areas. The wide list of associated CFDA numbers signals that nanoscale-enabled diagnostics and interventions may be relevant across many NIH missions, as long as the core innovation depends meaningfully on nanotechnology and aims to improve detection, monitoring, or treatment.
Which general topic areas are reflected by the CFDA numbers mentioned?
The CFDA list spans many areas, including oral health, genomics, deafness and communication disorders, sleep disorders, mental health, substance abuse, technological innovations for human health, arthritis and skin diseases, child health and development, aging, and vision research.
Is there a related STTR opportunity connected to this FOA?
Yes. This SBIR FOA ran in parallel with an equivalent-scoped Small Business Technology Transfer (STTR) opportunity: PA 10 149, using mechanisms R41/R42.
How is SBIR positioned differently from STTR in the description provided?
Based on the information provided, SBIR is described as small business-led R&D with subcontracting allowed. STTR is described as formally requiring collaboration with a nonprofit research institution. Applicants could consider which structure better fits their project.
When was the FOA posted and what were the closing dates?
The opportunity was posted and created on April 6, 2010. The original and final closing date was May 7, 2013. It was archived on June 7, 2013.
Is this funding opportunity still open?
No. Based on the dates provided, it closed on May 7, 2013 and was archived on June 7, 2013.
Where can the official NIH program page for PA-10-150 be found?
The official NIH program page listed for this FOA is: http://grants.nih.gov/grants/guide/pa-files/PA-10-150.html.
Who is listed as a contact for access or linking issues related to the NIH program page?
The NIH Office of Extramural Research (OER) webmaster contact emails were provided for access or linking issues (as described in the opportunity summary).
What is the overall goal of this NIH SBIR nanotechnology initiative?
The overall goal is to accelerate early-stage and mid-stage commercialization-focused R&D in nanoscale biomedical technologies, helping small businesses translate nanotechnology concepts into real diagnostic tools and therapeutic approaches that could ultimately be deployed in clinical care.
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