Opportunity Information: Apply for PA 14 168
Apply for PA 14 168
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Biology of Manual Therapies (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
- This funding opportunity was created on Mar 28, 2014 and posted on Mar 28, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: For profit organizations other than small businesses Small businesses Private institutions of higher education Public housing authorities/Indian housing authorities Independent school districts Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments State governments Native American tribal governments (Federally recognized) Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Biology of Manual Therapies (R01) funding opportunity (PA 14-168) was a National Institutes of Health (NIH) discretionary grant program in the Health funding activity area (CFDA 93.213, Research and Training in Complementary and Integrative Health). It invited standard NIH R01 research grant applications aimed at understanding the basic biology and mechanisms of action behind commonly used manual therapy approaches. The central purpose was not simply to test whether these therapies work, but to clarify how they work at a mechanistic level, with particular emphasis on neurophysiological effects and especially responses involving the central nervous system. At the same time, the FOA also encouraged studies that examine immunological, endocrinological, and biomechanical consequences of interventions such as spinal manipulation, mobilization, and massage therapy.
In practical terms, the opportunity supported projects that could connect manual therapy inputs (for example, the type of mechanical stimulus delivered, treatment parameters, or clinician-applied forces) to measurable biological outputs. Examples of the kinds of mechanistic domains highlighted by the announcement include changes in brain or spinal cord processing of pain and sensory information, autonomic nervous system activity, inflammatory or immune signaling, hormone or stress-axis responses, and tissue or movement-related biomechanics. The goal was to build a stronger basic-science foundation for manual therapies by identifying pathways and processes that explain observed clinical effects, variability in patient response, and potential markers that could predict who is most likely to benefit.
Eligibility was broad and included many organization types across the public, private, and nonprofit sectors. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (including both 501(c)(3) and certain non-501(c)(3) organizations outside universities), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state governments, county governments, cities or townships, special district governments, and public housing authorities/Indian housing authorities. The FOA also allowed applications from tribal governments (both federally recognized and other than federally recognized) and tribal organizations, as well as tribally controlled colleges and universities. It explicitly included eligibility for a number of institution categories such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, AANAPISI institutions, and other community-based and faith-based organizations, as applicable under NIH policy.
Notably, the program allowed non-U.S. participation. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, were eligible to apply, and non-domestic components of U.S. organizations could participate. Foreign components, as defined by the NIH Grants Policy Statement, were also allowed, meaning the FOA could support international collaborations when scientifically justified.
The funding opportunity did not require cost sharing or matching. It was posted on March 28, 2014, with the original closing date listed as May 7, 2017, and the final (current) closing date also May 7, 2017. The archive date was June 7, 2017, indicating that the announcement is no longer active for new submissions under that specific FOA. The official NIH listing and details were made available through the NIH Grants Guide at http://grants.nih.gov/grants/guide/pa-files/PA-14-168.html, and the NIH Office of Extramural Research (OER) webmaster contact was provided for access or technical issues (FBOWebmaster@OD.NIH.GOV).
Frequently Asked Questions (FAQs): The Biology of Manual Therapies (R01) - PA 14-168
What is the name of this NIH funding opportunity?
The opportunity is titled The Biology of Manual Therapies (R01) and is identified as PA 14-168.
What type of grant mechanism did this opportunity use?
It invited applications using the standard NIH R01 research project grant mechanism.
Which federal agency offered this program?
This was a National Institutes of Health (NIH) discretionary grant program.
What funding activity area and CFDA number were associated with this FOA?
The funding activity area was Health. The program was associated with CFDA 93.213, listed as Research and Training in Complementary and Integrative Health.
What was the main purpose of the FOA?
The central purpose was to support research that clarifies the basic biology and mechanisms of action behind commonly used manual therapy approaches. The emphasis was on explaining how these therapies work, not simply testing whether they work.
Did the FOA focus on clinical effectiveness or biological mechanisms?
The FOA emphasized mechanistic research. It was not designed primarily to evaluate whether manual therapies are effective; instead, it prioritized studies that explain the biological pathways and processes that might underlie observed effects.
Which manual therapy approaches were specifically mentioned?
Examples of interventions highlighted included spinal manipulation, mobilization, and massage therapy.
What kinds of biological effects were especially emphasized?
The announcement placed particular emphasis on neurophysiological effects, especially responses involving the central nervous system (for example, brain and spinal cord processing related to pain and sensory information).
Were non-neurophysiological mechanisms also encouraged?
Yes. The FOA also encouraged studies of immunological, endocrinological, and biomechanical consequences of manual therapy interventions.
What does it mean to connect "manual therapy inputs" to "biological outputs"?
Projects were encouraged to relate measurable features of the intervention (such as the type of mechanical stimulus, treatment parameters, or clinician-applied forces) to measurable biological responses (such as changes in nervous system activity, immune/inflammatory signaling, hormonal responses, or biomechanics).
What mechanistic domains were highlighted as examples in the FOA?
The FOA highlighted domains such as:
- Changes in brain or spinal cord processing of pain and sensory information
- Autonomic nervous system activity
- Inflammatory or immune signaling
- Hormone and stress-axis responses
- Tissue or movement-related biomechanics
Why did NIH sponsor this type of mechanistic manual therapy research?
The stated goal was to build a stronger basic-science foundation for manual therapies by identifying pathways and processes that could explain:
- Observed clinical effects
- Variability in patient response
- Potential markers that might predict who is most likely to benefit
Was cost sharing or matching required?
No. The FOA stated that it did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was broad and included many organization types across public, private, and nonprofit sectors. Eligible applicants included:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Nonprofits, including both 501(c)(3) and certain non-501(c)(3) organizations outside universities
- For-profit organizations, including small businesses and other for-profits
- Government entities such as state governments, county governments, cities or townships, special district governments, and public housing authorities/Indian housing authorities
Were tribal governments and tribal organizations eligible?
Yes. The FOA allowed applications from tribal governments (both federally recognized and other than federally recognized), as well as tribal organizations and tribally controlled colleges and universities.
Did the FOA mention eligibility for specific institution categories such as HBCUs and Hispanic-serving institutions?
Yes. It explicitly included eligibility for institution categories such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, AANAPISI institutions, and other community-based and faith-based organizations, as applicable under NIH policy.
Could non-U.S. organizations apply?
Yes. Non-domestic (non-U.S.) entities, including foreign organizations and foreign institutions, were eligible to apply.
Could a U.S. organization include non-U.S. components in the project?
Yes. Non-domestic components of U.S. organizations could participate, and foreign components (as defined by the NIH Grants Policy Statement) were allowed when scientifically justified.
When was this FOA posted?
The FOA was posted on March 28, 2014.
What were the closing dates for submission?
The original closing date was listed as May 7, 2017, and the final (current) closing date was also May 7, 2017.
Is PA 14-168 still open for new applications?
No. The FOA has an archive date of June 7, 2017, indicating the announcement is no longer active for new submissions under that specific FOA.
Where can someone find the official NIH listing for PA 14-168?
The official listing was available through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/pa-files/PA-14-168.html
Who was listed as a contact for access or technical issues related to the announcement?
The NIH Office of Extramural Research (OER) webmaster contact provided was FBOWebmaster@OD.NIH.GOV.
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