Opportunity Information: Apply for PA 14 167
Apply for PA 14 167
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Biology of Manual Therapies (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213 Research and Training in Complementary and Integrative Health.
- This funding opportunity was created on Mar 28, 2014 and posted on Mar 28, 2014.
- Applicants must submit their applications by May 7, 2017. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Small businesses Public housing authorities/Indian housing authorities Special district governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Native American tribal governments (Federally recognized) For profit organizations other than small businesses City or township governments Public and State controlled institutions of higher education County governments State governments Independent school districts.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
The Biology of Manual Therapies (R21) funding opportunity (PA 14-167) was a National Institutes of Health (NIH) discretionary grant program designed to support exploratory, early-stage research on the basic biology and mechanisms behind manual therapy interventions. The central purpose of the announcement was to encourage studies that move beyond clinical outcomes alone and instead clarify how therapies like spinal manipulation, mobilization, and massage produce measurable effects in the body. A major emphasis was placed on neurophysiological mechanisms, particularly responses involving the central nervous system, while also welcoming research on immunological, endocrinological, and biomechanical consequences. In practical terms, applicants were being invited to propose mechanistic studies that could explain what manual therapies are doing at the level of neural signaling and processing, immune activity and inflammation-related pathways, hormone and stress-response systems, and the mechanical and functional behavior of tissues and joints.
This opportunity used the NIH R21 mechanism, which is typically aimed at supporting innovative, higher-risk projects that can generate foundational data, establish feasibility, or open up new research directions. The listed award ceiling was $200,000, and there was no cost sharing or matching requirement, making it a relatively accessible pathway for teams seeking to build preliminary mechanistic evidence that could later justify larger-scale grants. The funding activity category was health, and it fell under CFDA 93.213, Research and Training in Complementary and Integrative Health, aligning the program with research priorities that examine complementary and integrative approaches through rigorous biomedical investigation.
Eligibility was broad and included many types of U.S.-based organizations, such as public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government applicants (state, county, city or township, special district governments, and independent school districts). The FOA also explicitly included a wide range of mission-driven and community-centered institution types, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based and community-based organizations where appropriate for the proposed work. Importantly, foreign participation was allowed: non-U.S. entities (foreign organizations and foreign institutions) could apply, non-U.S. components of U.S. organizations were eligible, and foreign components (as defined by NIH policy) were permitted. This structure signaled interest in supporting strong mechanistic science regardless of geography, provided the work met NIH standards and the FOA goals.
From an administrative timeline standpoint, the opportunity was posted and created on March 28, 2014, with an original and current closing date of May 7, 2017, and it was archived on June 7, 2017. The sponsoring agency was NIH, and the official announcement and details were hosted on the NIH grants site. The FOA also provided basic support contacts through the NIH Office of Extramural Research (OER) web help addresses for access or linking problems.
In summary, PA 14-167 was built to accelerate rigorous mechanistic research on manual therapies by funding exploratory R21 projects that could explain how hands-on interventions influence central nervous system activity and related physiological systems, including immune and endocrine signaling as well as biomechanical function. The underlying goal was to strengthen the scientific foundation for manual therapy approaches by identifying and characterizing measurable biological processes that could account for observed therapeutic effects.
FAQs: The Biology of Manual Therapies (R21) - PA 14-167
What is the Biology of Manual Therapies (R21) funding opportunity (PA 14-167)?
PA 14-167 was a National Institutes of Health (NIH) discretionary grant opportunity that supported exploratory, early-stage research focused on the basic biology and underlying mechanisms of manual therapy interventions.
What was the main purpose of PA 14-167?
The announcement aimed to encourage studies that go beyond measuring clinical outcomes and instead clarify how manual therapies (such as spinal manipulation, mobilization, and massage) produce measurable biological effects in the body.
What kinds of therapies were specifically mentioned as examples of manual therapies?
The opportunity highlighted therapies such as spinal manipulation, mobilization, and massage as examples of manual therapy interventions of interest.
What type of research was this FOA trying to promote?
This FOA emphasized mechanistic, basic biology research designed to explain what manual therapies are doing at a biological and physiological level, rather than focusing only on whether a therapy improves symptoms or outcomes.
What biological systems or mechanisms were emphasized?
A major emphasis was placed on neurophysiological mechanisms, particularly responses involving the central nervous system. The FOA also welcomed studies examining immunological, endocrinological, and biomechanical consequences of manual therapy interventions.
What does “mechanistic study†mean in the context of this opportunity?
In this context, mechanistic studies are designed to identify and characterize measurable biological processes that could explain observed effects of manual therapies. The FOA pointed to areas such as neural signaling and processing, immune activity and inflammation-related pathways, hormone and stress-response systems, and the mechanical and functional behavior of tissues and joints.
What grant mechanism was used for this opportunity?
The opportunity used the NIH R21 mechanism.
What is the intent of the NIH R21 mechanism?
The R21 mechanism is typically used to support innovative, higher-risk projects that can generate foundational data, establish feasibility, or open new research directions. In this program, it was positioned as a way to build preliminary mechanistic evidence that could support later, larger studies.
What was the award ceiling for PA 14-167?
The listed award ceiling was $200,000.
Was cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
What was the funding activity category?
The funding activity category was health.
Which CFDA number was associated with this opportunity?
The opportunity fell under CFDA 93.213, Research and Training in Complementary and Integrative Health.
How does CFDA 93.213 relate to the focus of this FOA?
CFDA 93.213 aligns with research priorities examining complementary and integrative approaches through rigorous biomedical investigation, which matches the FOA’s goal of strengthening the biological and mechanistic evidence base for manual therapies.
Who was eligible to apply?
Eligibility was broad and included many types of U.S.-based organizations, including public and private institutions of higher education, nonprofit organizations (both 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses and other for-profit entities), and multiple levels of government applicants (state, county, city or township, special district governments, and independent school districts).
Were mission-driven and community-centered institutions included in the eligible applicant types?
Yes. The FOA explicitly included a wide range of institution types, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), and also referenced faith-based and community-based organizations where appropriate for the proposed work.
Were for-profit organizations eligible to apply?
Yes. For-profit organizations, including small businesses and other for-profit entities, were included among eligible applicants.
Were government entities eligible to apply?
Yes. The eligible applicant types included state governments, county governments, city or township governments, special district governments, and independent school districts.
Was foreign participation allowed?
Yes. The FOA allowed foreign participation, including applications from non-U.S. entities (foreign organizations and foreign institutions), non-U.S. components of U.S. organizations, and foreign components (as defined by NIH policy).
What did the FOA’s foreign eligibility language suggest about NIH priorities for this program?
Based on the FOA description provided, it signaled an interest in supporting strong mechanistic science regardless of geography, as long as the work met NIH standards and aligned with the FOA’s goals.
When was PA 14-167 posted and created?
The opportunity was posted and created on March 28, 2014.
What was the closing date for this opportunity?
The original and current closing date was May 7, 2017.
Is this funding opportunity still active?
No. The opportunity was archived on June 7, 2017.
Who sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
Where were the official announcement and details hosted?
The official announcement and details were hosted on the NIH grants site.
What kinds of support contacts were referenced for administrative or website issues?
The FOA referenced basic support contacts through the NIH Office of Extramural Research (OER) web help addresses for access or linking problems.
What was the overall goal of PA 14-167 in plain terms?
The program aimed to accelerate rigorous mechanistic research on manual therapies by funding exploratory R21 projects that could identify and characterize measurable biological processes (especially central nervous system-related mechanisms, as well as immune, endocrine, and biomechanical pathways) that might account for observed therapeutic effects.
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