Opportunity Information: Apply for RFA NS 27 001
Apply for RFA NS 27 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.372.
- This funding opportunity was created on 2026-02-09.
- Applicants must submit their applications by 2028-10-06.
- The number of recipients for this funding is limited to 20 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Opportunity Summary:
The BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24, Clinical Trial Not Allowed) is an NIH funding opportunity designed to help proven neuroscience resources reach broad, routine use across the research community. The central idea is not to invent a brand-new technology from scratch, but to take an existing, valuable resource and make it easier for many labs to access, adopt, and integrate into day-to-day neuroscience research. NIH is looking for resources that clearly align with the BRAIN Initiative scientific priorities described in BRAIN 2025: A Scientific Vision and The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures, and that can be shared widely rather than kept within a narrow set of collaborators.
Projects must include dissemination of an existing resource, meaning applicants need to show they already have something workable and useful, and the proposed award would primarily support getting it into the hands of more users. Beyond basic dissemination, applicants may also propose complementary activities that make dissemination realistic and impactful. Examples called out in the notice include distributing tools and reagents; providing user training so researchers can correctly implement new methods or technologies; offering access to established technology platforms and/or specialized facilities that are otherwise hard to reach; and making minor improvements that increase the scale, efficiency, reliability, or throughput of producing and delivering the resource. Minor adaptations are also allowed when they are needed to meet the practical needs of a broader user community, but the emphasis stays on integration and spread, not major redevelopment.
This opportunity uses the U24 cooperative agreement mechanism, which typically means NIH expects an active partnership with awardees rather than a hands-off grant. While the notice text provided does not list all management expectations, applicants should generally anticipate milestone-driven planning, strong user-support and outreach components, clear governance and operations plans, and a credible strategy for maintaining quality and availability as demand grows. Importantly, the NOFO explicitly states "Clinical Trial Not Allowed," so the activities supported here should not involve clinical trial work as defined by NIH.
Eligibility is broad across U.S.-based organizations and includes many common applicant types: state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (including small businesses and other for-profits); and other eligible entities as described in the full NOFO. The key limitation is that non-U.S. entities cannot apply: non-domestic (non-U.S.) organizations are not eligible applicants, and non-domestic components of U.S. organizations are also not eligible to apply as the applicant organization.
The notice includes significant restrictions related to international collaboration and funding flows. While foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed, NIH policy effective May 1, 2025 prohibits NIH from issuing awards that involve foreign subawards or subcontracts unless the application is submitted under a funding opportunity specifically designated for funded international collaborations. As a result, applications to this NOFO that include foreign subawards/subcontracts will be considered noncompliant and will not be reviewed for funding. At the same time, the policy does not bar all forms of international involvement: it does not preclude unfunded international collaborations, permitted foreign components, paying foreign consultants, or purchasing unique equipment or supplies from foreign vendors, as long as the arrangement does not constitute a foreign subaward/subcontract that violates the stated restriction.
Administratively, the program is offered by the National Institutes of Health under CFDA (Assistance Listing) 93.372, categorized under Health. The funding instrument is a cooperative agreement, and the opportunity number is RFA-NS-27-001. The opportunity is listed with an original closing date of October 6, 2028, and NIH anticipates making about 20 awards. No award ceiling is specified in the provided listing, so applicants would need to consult the full NOFO for budget guidance, allowable cost details, and any institute-specific expectations.
Overall, NIH is signaling a strong preference for practical, community-serving projects that remove barriers to adoption of BRAIN-relevant tools, platforms, or methods. Competitive applications will typically be those that can clearly articulate the unmet need, demonstrate the resource is already credible and useful, provide a concrete dissemination and user-support plan (distribution logistics, training, access model, documentation, and outreach), and show how small, targeted improvements or adaptations will materially increase usability and impact across the broader neuroscience community while staying within the non-clinical-trial scope.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is an NIH BRAIN Initiative funding opportunity called "The BRAIN Initiative: Research Resource Grants for Technology Integration and Dissemination (U24, Clinical Trial Not Allowed)." It supports efforts to help proven neuroscience resources reach broad, routine use across the research community by making them easier to access, adopt, and integrate into day-to-day research.
What is the main goal of the program?
The main goal is dissemination and integration of an existing, valuable neuroscience resource so that many labs can use it routinely. The focus is on removing barriers to adoption and enabling wide sharing rather than keeping a resource limited to a narrow group of collaborators.
Is this opportunity meant to fund brand-new technology development?
No. The central idea is not to invent a brand-new technology from scratch. Applicants are expected to already have something workable and useful, and the award would primarily support getting it into the hands of more users.
What kinds of resources are appropriate for this program?
Resources that align with the BRAIN Initiative scientific priorities described in BRAIN 2025: A Scientific Vision and The BRAIN Initiative 2.0: From Cells to Circuits, Toward Cures, and that can be shared widely across the neuroscience research community.
What does NIH mean by "dissemination" in this context?
Dissemination means distributing an existing resource and supporting its uptake so it can be used broadly and routinely. Applicants should be able to show the resource already exists, is credible and useful, and that the proposed work is primarily about scaling access and adoption.
What activities can be included to support dissemination?
The notice highlights complementary activities that make dissemination realistic and impactful, including distributing tools and reagents; providing user training so researchers can implement methods correctly; offering access to established technology platforms and/or specialized facilities that are otherwise hard to reach; and making minor improvements that increase the scale, efficiency, reliability, or throughput of producing and delivering the resource.
Are improvements or changes to the resource allowed?
Yes, but they are expected to be minor. Minor improvements are allowed when they increase scale, efficiency, reliability, or throughput. Minor adaptations are also allowed when needed to meet practical needs of a broader user community. The emphasis remains on integration and dissemination, not major redevelopment.
What type of award mechanism is used?
This opportunity uses the U24 cooperative agreement mechanism.
What does a U24 cooperative agreement typically imply for award management?
A U24 cooperative agreement typically means NIH expects an active partnership with awardees rather than a hands-off grant. Based on the notice summary, applicants should generally anticipate milestone-driven planning, strong user-support and outreach components, clear governance and operations plans, and a credible strategy for maintaining quality and availability as demand grows.
Are clinical trials allowed under this opportunity?
No. The NOFO explicitly states "Clinical Trial Not Allowed," so supported activities should not involve clinical trial work as defined by NIH.
Who is eligible to apply?
Eligibility is broad across U.S.-based organizations and includes state, county, and local governments; special districts; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (with or without 501(c)(3) status); for-profit organizations (including small businesses); and other eligible entities as described in the full NOFO.
Are non-U.S. (non-domestic) organizations eligible to apply?
No. Non-domestic (non-U.S.) organizations are not eligible applicants. In addition, non-domestic components of U.S. organizations are not eligible to apply as the applicant organization.
Are foreign components allowed?
Yes. Foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed, but they must be handled in a way that complies with NIH restrictions described for this opportunity.
Are foreign subawards or subcontracts allowed?
No. NIH policy effective May 1, 2025 prohibits NIH from issuing awards that involve foreign subawards or subcontracts unless the application is submitted under a funding opportunity specifically designated for funded international collaborations. Applications to this NOFO that include foreign subawards/subcontracts will be considered noncompliant and will not be reviewed for funding.
Does the restriction on foreign subawards/subcontracts prohibit all international collaboration?
No. The policy does not bar all forms of international involvement. It does not preclude unfunded international collaborations, permitted foreign components, paying foreign consultants, or purchasing unique equipment or supplies from foreign vendors, as long as the arrangement does not constitute a foreign subaward/subcontract that violates the stated restriction.
What is the opportunity number for this NOFO?
The opportunity number is RFA-NS-27-001.
What is the Assistance Listing (CFDA) number associated with this opportunity?
The program is offered under CFDA (Assistance Listing) 93.372.
What type of funding instrument is this?
The funding instrument is a cooperative agreement.
What is the original closing date listed for this opportunity?
The listing shows an original closing date of October 6, 2028.
How many awards does NIH expect to make?
NIH anticipates making about 20 awards.
Is there an award ceiling (maximum budget) stated in the provided information?
No award ceiling is specified in the provided listing. Applicants are expected to consult the full NOFO for budget guidance, allowable costs, and any institute-specific expectations.
What kinds of dissemination plans are likely to be viewed as competitive?
Based on the description provided, competitive projects typically articulate the unmet need, demonstrate the resource is already credible and useful, provide a concrete dissemination and user-support plan (distribution logistics, training, access model, documentation, and outreach), and explain how small, targeted improvements or adaptations will materially increase usability and impact across the broader neuroscience community while remaining within the non-clinical-trial scope.
What is NIH signaling it wants to see in proposed projects?
NIH is signaling a strong preference for practical, community-serving projects that remove barriers to adoption of BRAIN-relevant tools, platforms, or methods and make them broadly available for routine use.
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