Opportunity Information: Apply for PAR 26 042
Apply for PAR 26 042
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Grants in Clinical Informatics (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.879.
- This funding opportunity was created on 2026-02-11.
- Applicants must submit their applications by 2029-03-05.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- The number of recipients for this funding is limited to 10 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Opportunity Summary:
Research Grants in Clinical Informatics (R01 Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity from the National Library of Medicine (NLM) aimed at pushing clinical informatics forward through genuinely innovative research. The program is built around the idea that health care generates massive amounts of digital data, but too much of it remains difficult to use in ways that reliably help clinicians, patients, health systems, and communities. NLM is looking for projects that develop and rigorously evaluate new informatics methods and tools that can turn messy, heterogeneous clinical data into actionable knowledge that improves care delivery and health outcomes. While clinical trials are optional under this opportunity, the core expectation is strong research that advances the science and practice of clinical informatics.
A central theme of the opportunity is generalizability: NLM emphasizes domain-independent approaches that can scale and be reused across diseases, institutions, and populations. Proposals should focus on methods that are not just one-off solutions for a single hospital, specialty, or dataset, but instead are designed to be broadly applicable and reproducible. The NOFO highlights the full range of health-related digital objects that modern informatics must handle, including electronic health records (EHRs), unstructured clinical notes, imaging data, and patient-generated data (for example, data from wearables, home monitoring, surveys, portals, or apps). Competitive projects will typically show how they will discover, organize, analyze, and manage these data types in ways that support data-driven discovery, evidence-based decision-making, and more personalized or precision-oriented care.
The kinds of outcomes NLM is signaling interest in include practical tools and methods that can be implemented in real settings and evaluated in terms that matter, such as improvements to clinical workflows, better decision support, stronger evidence generation from routine care data, and clearer pathways from raw data to usable clinical insights. This means proposals should not only introduce new algorithms, architectures, standards approaches, or evaluation methods, but also show a plan for implementation and assessment in realistic clinical environments. Overall, the program is positioned to fund work that accelerates scientific insight and converts innovation into something that could be adopted across multiple clinical settings rather than remaining a prototype.
From an administrative standpoint, this is an R01 research grant mechanism under a discretionary funding category in health (Assistance Listing/CFDA 93.879). The funding opportunity number is PAR-26-042, and it is expected to make about 10 awards. The listed award ceiling is $250,000 (as provided in the source data). The opportunity was created on 2026-02-11, and the original closing date is 2029-03-05, indicating a multi-year window during which applications may be accepted according to NIH submission cycles and the NOFOs schedule.
Eligibility is broad and includes many typical NIH-eligible organization types: state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (both 501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified); for-profit organizations other than small businesses; small businesses; and other eligible entities as described in the NOFOs Section III.
International participation is allowed but has an important compliance boundary. Foreign (non-U.S.) organizations may apply, and U.S. organizations may include non-U.S. components; foreign components as defined in NIH policy are permitted. However, NIH policy effective May 1, 2025 restricts awards that involve foreign subawards or subcontracts unless the application is submitted to a NOFO specifically designated for funded international collaborations. Under this particular opportunity, applications that include foreign subawards/subcontracts are considered noncompliant and will not be reviewed for funding. That said, the policy does not prohibit unfunded international collaborations, foreign components (as allowed under NIH rules), payment for foreign consultants, or purchasing unique equipment or supplies from foreign vendors. Applicants considering any international involvement need to structure collaborations carefully to avoid disallowed foreign subaward/subcontract arrangements under this NOFO.
Frequently Asked Questions (FAQs): Research Grants in Clinical Informatics (R01 Clinical Trial Optional) - PAR-26-042
What is this funding opportunity?
This opportunity is an NIH research grant focused on advancing clinical informatics through innovative research. It is titled "Research Grants in Clinical Informatics (R01 Clinical Trial Optional)" and is sponsored by the National Library of Medicine (NLM), part of the National Institutes of Health (NIH).
What is the main goal of the program?
The goal is to develop and rigorously evaluate new informatics methods and tools that can turn complex, messy, and heterogeneous clinical data into actionable knowledge that improves care delivery and health outcomes for clinicians, patients, health systems, and communities.
What is meant by "clinical informatics" in this opportunity?
In this context, clinical informatics refers to research that helps discover, organize, analyze, manage, and use health-related digital data (for example, EHR data and other clinical data streams) to support evidence-based decision-making, data-driven discovery, and more personalized or precision-oriented care.
Is a clinical trial required?
No. Clinical trials are optional under this opportunity. The core expectation is strong research that advances the science and practice of clinical informatics, whether or not a clinical trial is included.
What grant mechanism is used?
This is an R01 research grant mechanism.
What is the funding opportunity number?
The funding opportunity number is PAR-26-042.
What is the Assistance Listing (CFDA) number?
The Assistance Listing/CFDA number provided is 93.879.
How many awards are expected?
The opportunity is expected to make about 10 awards.
What is the maximum award amount (award ceiling)?
The listed award ceiling is $250,000 (as provided in the source data).
When was this opportunity created?
The opportunity was created on 2026-02-11.
What is the closing date for this opportunity?
The original closing date is 2029-03-05. This indicates a multi-year window during which applications may be accepted according to NIH submission cycles and the NOFO's schedule.
What types of projects is NLM looking to fund?
NLM is looking for projects that develop and rigorously evaluate genuinely innovative informatics methods and tools that improve the usability of clinical data and translate that data into knowledge that can improve healthcare delivery and outcomes.
What does NLM mean by "generalizability"?
Generalizability is a central theme of this opportunity. NLM emphasizes domain-independent approaches that can scale and be reused across diseases, institutions, and populations. Projects are expected to avoid being one-off solutions limited to a single hospital, specialty, or dataset and instead be designed for broad applicability and reproducibility.
What kinds of data does the NOFO highlight?
The NOFO highlights a wide range of health-related digital objects, including electronic health records (EHRs), unstructured clinical notes, imaging data, and patient-generated data (such as data from wearables, home monitoring, surveys, portals, or apps).
Are projects expected to work with messy or heterogeneous clinical data?
Yes. A key motivation of the program is that healthcare generates massive amounts of digital data, but much of it is difficult to use reliably. Competitive projects will typically address how to work with messy, heterogeneous clinical data to generate actionable insights.
What kinds of approaches or innovations are relevant?
The opportunity signals interest in new algorithms, architectures, standards approaches, and evaluation methods, as long as the work advances clinical informatics and includes rigorous evaluation.
Is implementation in real clinical settings important?
Yes. Proposals are expected to include a plan for implementation and assessment in realistic clinical environments, not just development of a prototype.
What types of outcomes or impacts does NLM want to see?
Examples of outcomes NLM signals interest in include improved clinical workflows, better decision support, stronger evidence generation from routine care data, and clearer pathways from raw data to usable clinical insights, with tools and methods that can be implemented and evaluated in real settings.
Who is eligible to apply?
Eligibility is broad and includes: state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofits (501(c)(3) and non-501(c)(3), excluding institutions of higher education where specified); for-profit organizations other than small businesses; small businesses; and other eligible entities as described in Section III of the NOFO.
Are international (non-U.S.) organizations allowed to apply?
Yes. Foreign (non-U.S.) organizations may apply, and U.S. organizations may include non-U.S. components. Foreign components (as defined in NIH policy) are permitted under NIH rules.
Are foreign subawards or subcontracts allowed under this opportunity?
No. NIH policy effective May 1, 2025 restricts awards involving foreign subawards or subcontracts unless the application is submitted to a NOFO specifically designated for funded international collaborations. Under this opportunity, applications that include foreign subawards/subcontracts are considered noncompliant and will not be reviewed for funding.
If foreign subawards are not allowed, what kinds of international involvement are still permitted?
The policy described does not prohibit unfunded international collaborations, allowed foreign components under NIH rules, payment for foreign consultants, or purchasing unique equipment or supplies from foreign vendors. Applicants need to structure any international involvement carefully to avoid disallowed foreign subaward/subcontract arrangements under this NOFO.
Can a U.S. organization include a non-U.S. component in the project?
Yes. The information provided states that U.S. organizations may include non-U.S. components, and foreign components (as defined in NIH policy) are permitted, as long as the application does not include foreign subawards/subcontracts that would make it noncompliant under this NOFO.
What happens if an application includes a foreign subaward or subcontract?
Applications that include foreign subawards/subcontracts under this opportunity are considered noncompliant and will not be reviewed for funding.
What is the program's overall emphasis: prototypes or adoptable solutions?
The program is positioned to fund work that accelerates scientific insight and converts innovation into tools and methods that could be adopted across multiple clinical settings, rather than remaining a one-off prototype.
Does the opportunity emphasize reproducibility?
Yes. The emphasis on generalizability includes designing methods that are broadly applicable and reproducible across diseases, institutions, and populations.
What kinds of healthcare stakeholders are expected to benefit from funded projects?
The opportunity is framed around benefiting clinicians, patients, health systems, and communities by making clinical data more usable and turning it into actionable knowledge that improves care and outcomes.
Is this opportunity limited to one disease area or clinical specialty?
No. A core theme is domain-independent work that can scale and be reused across diseases, institutions, and populations, rather than being tailored to a single specialty or site.
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