Opportunity Information: Apply for RFA EB 15 006
Apply for RFA EB 15 006
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "BRAIN Theories, Models and Methods for Analysis of Complex Data from the Brain (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.173 Research Related to Deafness and Communication Disorders 93.213 Research and Training in Complementary and Integrative Health 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs 93.286 Discovery and Applied Research for Technological Innovations to Improve Human Health 93.313 NIH Office of Research on Womens Health 93.853 Extramural Research Programs in the Neurosciences and Neurological Disorders 93.865 Child Health and Human Development Extramural Research 93.866 Aging Research 93.867 Vision Research.
- This funding opportunity was created on Jul 31, 2015 and posted on Jul 31, 2015.
- Applicants must submit their applications by Oct 21, 2015. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $6,000,000.00 to eligible and selected applicants.
- Eligible applicants include: State governments Native American tribal governments (Federally recognized) Small businesses Public housing authorities/Indian housing authorities County governments Public and State controlled institutions of higher education City or township governments Native American tribal organizations (other than Federally recognized tribal governments) For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts Special district governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The funding opportunity "BRAIN Theories, Models and Methods for Analysis of Complex Data from the Brain (R01)" (Funding Opportunity Number RFA-EB-15-006) is a National Institutes of Health (NIH) grant competition created under the broader goals of the BRAIN Initiative. Its central purpose is to push neuroscience forward by developing fundamentally new ways to make sense of the increasingly large, high-dimensional, and messy datasets produced by modern brain research. Rather than focusing on collecting more data, the FOA emphasizes the need for new intellectual and technical machinery to translate complex recordings and measurements into real understanding of how the brain works.
At its core, this FOA invites applications that propose new theories, computational models, and mathematical or statistical methods aimed at extracting principles of brain function from complex neuroscience data. The program is explicitly interested in approaches that can help researchers move from description to explanation: organizing disparate observations, identifying patterns that matter, testing mechanistic hypotheses, and making predictions that can be checked experimentally. Projects may center on building new conceptual frameworks that unify findings across experiments or scales, designing computational models that generate testable hypotheses and can guide the next experiments, or creating statistical and mathematical tools that can detect meaningful features in complex brain data and evaluate whether the data support or contradict a stated hypothesis about neural function.
A key expectation built into the announcement is that the methods, models, and approaches developed will not remain locked within a single lab. The FOA signals that outputs should be made widely available to the neuroscience community for use and modification, reflecting an emphasis on field-wide impact and reusability. In practice, that typically implies sharable software, accessible model implementations, clear documentation, and a design philosophy that supports adoption by other groups working on different datasets or brain systems.
This is an R01 mechanism, meaning it supports substantial, hypothesis-driven research projects with enough scope to develop and validate new analytic approaches. The opportunity is categorized as a discretionary grant, and it falls under broad public mission areas that include education, health, and social services, consistent with NIH biomedical research aims. The announcement lists multiple CFDA program numbers spanning neuroscience and related domains (for example, mental health, aging, vision research, neurological disorders, substance use, and technological innovations for human health), which signals that the work is intended to be broadly relevant across many NIH mission areas, not confined to one narrow disease or institute priority.
On eligibility, the FOA is expansive and inclusive. Eligible applicants include a wide range of domestic and non-domestic organizations: state, county, city, township, and special district governments; federally recognized tribal governments and other tribal organizations; public and private institutions of higher education; nonprofits (including 501(c)(3) and certain non-501(c)(3) entities); small businesses and other for-profit organizations; independent school districts; public housing authorities; and additional categories such as faith-based and community-based organizations, minority-serving institutions (including HBCUs, HSIs, AANAPISIs, TCCUs, Alaska Native and Native Hawaiian Serving Institutions), regional organizations, U.S. territories or possessions, eligible federal agencies, and foreign organizations. The FOA also states there is no cost sharing or matching requirement, which lowers the barrier for applicants who might otherwise struggle to meet mandatory non-federal match commitments.
In terms of timing and scale, the opportunity was posted and created on July 31, 2015, with an original and current closing date of October 21, 2015, and an archive date of November 21, 2015. The estimated total funding level listed is $6,000,000, indicating a moderate pool intended to support a set of awards rather than a single large center. The sponsoring agency is NIH, and the announcement provides a link to the full solicitation on the NIH grants site (http://grants.nih.gov/grants/guide/rfa-files/RFA-EB-15-006.html). For access or technical issues, the contact route provided is the NIH Office of Extramural Research (OER) webmaster.
Overall, the FOA is best understood as a call for foundational advances in the ideas and tools needed to interpret complex brain data, with an emphasis on rigorous theory, model-based reasoning, and modern statistical methodology, and with a clear expectation that the resulting products will be disseminated in a way that accelerates progress across the neuroscience community.
Frequently Asked Questions (FAQs)
What is the name of this funding opportunity?
The opportunity is titled "BRAIN Theories, Models and Methods for Analysis of Complex Data from the Brain (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-EB-15-006.
Which agency is sponsoring this grant competition?
The sponsoring agency is the National Institutes of Health (NIH).
How does this opportunity relate to the BRAIN Initiative?
This competition was created under the broader goals of the BRAIN Initiative and is aimed at enabling major advances in how complex brain data are interpreted and understood.
What is the central purpose of this FOA?
The central purpose is to push neuroscience forward by developing fundamentally new theories, computational models, and mathematical or statistical methods that can make sense of large, high-dimensional, and noisy neuroscience datasets and translate them into real understanding of how the brain works.
Is this FOA focused on collecting new data?
No. The emphasis is not on collecting more data. The focus is on creating new intellectual and technical approaches to analyze and interpret complex brain data that already exist or are being generated by modern neuroscience.
What kinds of projects does the FOA invite?
The FOA invites applications proposing new theories, computational models, and mathematical or statistical methods aimed at extracting principles of brain function from complex neuroscience data.
What does "move from description to explanation" mean in this context?
It refers to approaches that go beyond summarizing or visualizing data and instead help organize observations, identify meaningful patterns, test mechanistic hypotheses, and generate predictions that can be checked experimentally.
What are examples of the types of outputs this FOA is looking for?
Examples described in the announcement include new conceptual frameworks that unify findings across experiments or scales, computational models that produce testable hypotheses and guide future experiments, and statistical or mathematical tools that can detect meaningful features in complex brain data and evaluate whether data support or contradict a stated hypothesis about neural function.
Does the FOA expect tools and methods to be shared with other researchers?
Yes. A key expectation is that methods, models, and approaches developed should be made widely available to the neuroscience community for use and modification, reflecting an emphasis on broad impact and reusability.
What does "widely available" imply for project deliverables?
Based on the announcement language, it implies outputs should not remain locked within a single lab and should support community adoption. In practice, that typically means sharable software or model implementations, clear documentation, and designs that enable use by other groups working on different datasets or brain systems.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R01 mechanism.
What does the R01 mechanism indicate about project scope?
It indicates support for substantial, hypothesis-driven research projects with enough scope to develop and validate new analytic approaches.
What type of grant is this categorized as?
It is categorized as a discretionary grant.
What broad mission areas does this opportunity relate to?
It falls under broad public mission areas including education, health, and social services, consistent with NIH biomedical research aims.
Is the opportunity tied to a single disease area or NIH institute priority?
No. The announcement lists multiple CFDA program numbers spanning neuroscience and related domains, signaling that the intended relevance is broad across NIH mission areas rather than confined to one narrow disease area.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes domestic and non-domestic organizations, including various levels of government, tribal governments and organizations, public and private institutions of higher education, nonprofits, small businesses and other for-profit organizations, independent school districts, public housing authorities, and other categories such as faith-based and community-based organizations, minority-serving institutions, regional organizations, U.S. territories or possessions, eligible federal agencies, and foreign organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. The FOA explicitly includes foreign organizations among eligible applicants.
Are for-profit entities eligible to apply?
Yes. The eligible applicant types include small businesses and other for-profit organizations.
Are nonprofits eligible to apply?
Yes. The eligible applicant types include nonprofits, including 501(c)(3) and certain non-501(c)(3) entities.
Are minority-serving institutions explicitly included in eligibility?
Yes. The eligibility description explicitly includes minority-serving institutions, including HBCUs, HSIs, AANAPISIs, TCCUs, and Alaska Native and Native Hawaiian Serving Institutions.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was the opportunity posted?
The opportunity was posted (created) on July 31, 2015.
What was the closing date for applications?
The original and current closing date listed is October 21, 2015.
When was the opportunity archived?
The archive date listed is November 21, 2015.
How much total funding is estimated for this FOA?
The estimated total funding level listed is $6,000,000.
Does the total funding amount suggest one award or multiple awards?
The announcement describes the total as a moderate pool intended to support a set of awards rather than a single large center.
Where can applicants find the full solicitation text?
The announcement points to the NIH grants site at http://grants.nih.gov/grants/guide/rfa-files/RFA-EB-15-006.html.
Who should be contacted for access or technical issues related to the announcement?
For access or technical issues, the provided contact route is the NIH Office of Extramural Research (OER) webmaster.
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