Opportunity Information: Apply for PA 15 317
Apply for PA 15 317
- The National Institutes of Health in the food and nutrition health sector is offering a public funding opportunity titled "Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research.
- This funding opportunity was created on Jul 31, 2015 and posted on Jul 31, 2015.
- Applicants must submit their applications by Sep 7, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: City or township governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Private institutions of higher education Special district governments County governments Public housing authorities/Indian housing authorities State governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Independent school districts For profit organizations other than small businesses Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Asian American Native American Pacific Islander Serving Institutions (AANAPISISs) Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are not eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
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Opportunity Summary:
The funding opportunity PA 15 317, titled "Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21)," was a National Institutes of Health (NIH) discretionary grant program designed to support early-stage, exploratory clinical and translational research focused on digestive, liver, and nutrition-related diseases. The main goal was to help researchers generate initial human or clinically relevant evidence, establish proof of concept, or develop the preliminary data needed to justify a larger, more definitive clinical or translational study later on. As an R21 mechanism, it was geared toward innovative, high-impact ideas that may still be at an earlier stage of development, where smaller-scale funding can help clarify feasibility, refine study procedures, and demonstrate whether a research direction is promising.
This program specifically emphasized pilot and feasibility studies in digestive and liver diseases, aligning with the NIH mission area captured under CFDA 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research). While the title includes "Digestive Diseases and Nutrition," the focus described in the listing highlights clinical and translational work, meaning projects were expected to have a clear path toward improving diagnosis, prevention, treatment, clinical management, or understanding of human disease in ways that could ultimately affect patient care. In practical terms, the kinds of projects that typically fit an FOA like this include small early-phase clinical studies, the testing of new clinical approaches or tools in a limited population, the development and validation of clinically meaningful biomarkers, or the adaptation of laboratory discoveries into approaches that can be evaluated in humans or in settings that closely mirror clinical care. The emphasis on feasibility also suggests the FOA aimed to fund work that answers questions like whether recruitment is realistic, whether an intervention can be delivered as planned, whether measurements and outcomes can be captured reliably, and whether effect sizes or signals are strong enough to warrant a larger trial.
From an applicant standpoint, the opportunity was broadly available to a wide range of U.S.-based organizations, reflecting NIH's typical approach to expanding participation across academic, nonprofit, governmental, and private-sector research environments. Eligible applicants included public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (other than institutions of higher education), small businesses, and other for-profit entities (including those other than small businesses). Governmental entities at multiple levels were also eligible, including state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities or Indian housing authorities. The eligibility list also explicitly included various mission-driven and capacity-building institution types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), as well as faith-based or community-based organizations and regional organizations. In addition, certain eligible agencies of the federal government could apply. At the same time, the program drew a clear boundary around foreign participation: non-U.S. (foreign) institutions were not eligible to apply, non-U.S. components of U.S. organizations were not eligible, and foreign components (as defined by NIH policy) were not allowed.
Financially, the grant had an award ceiling listed at $200,000, and it did not require cost sharing or matching, which generally lowers barriers for institutions that may not have discretionary funds to contribute. The listing identifies the funding instrument as a grant and classifies it within the funding activity category of food and nutrition/health, consistent with NIH support for biomedical and clinical research that intersects digestive health, metabolic processes, and nutrition-related factors.
In terms of timing and status, the opportunity was posted and created on July 31, 2015. The original and current closing date shown is September 7, 2018, and the archive date is October 8, 2018. That means the FOA is no longer active for new submissions under that specific announcement, and prospective applicants would typically need to look for a reissued FOA, a related active NIH funding announcement, or the current NIDDK/NIH R21 options that match the same scientific intent.
Administrative details in the listing point applicants to the full announcement on the NIH Grants Guide website, and provide a general NIH Office of Extramural Research (OER) webmaster contact for access or linking issues. The sponsoring agency is the National Institutes of Health, and the overall intent is straightforward: help investigators move promising digestive and liver disease clinical and translational concepts from an idea or early data stage into a position where they can compete for larger, later-phase clinical or translational funding.
FAQs: PA-15-317 Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21)
What is PA-15-317?
PA-15-317 was a National Institutes of Health (NIH) discretionary grant funding opportunity titled "Pilot and Feasibility Clinical and Translational Research Studies in Digestive Diseases and Nutrition (R21)." It supported early-stage, exploratory clinical and translational research in digestive diseases, liver diseases, and nutrition-related conditions.
What was the main purpose of this funding opportunity?
The program was designed to help researchers generate initial human or clinically relevant evidence, establish proof of concept, and produce preliminary data needed to justify a larger, more definitive clinical or translational study later on.
What grant mechanism did this opportunity use?
This opportunity used the NIH R21 mechanism, which is commonly used for innovative, high-impact ideas that are still at an earlier stage of development and need smaller-scale support to test feasibility and early signals.
What kinds of research did PA-15-317 emphasize?
It emphasized pilot and feasibility clinical and translational studies related to digestive diseases, liver diseases, and nutrition. Projects were expected to have a clear path toward improving diagnosis, prevention, treatment, clinical management, or understanding of human disease in ways that could ultimately affect patient care.
What does "clinical and translational" mean in the context of this opportunity?
Based on the listing description, clinical and translational work meant projects that move discoveries toward human application or clinically relevant settings, with an emphasis on generating evidence or practical knowledge that could inform patient care or set up a larger study.
What types of studies were likely a fit for this FOA?
Examples described as typically fitting an FOA like this included small early-phase clinical studies, testing new clinical approaches or tools in a limited population, development and validation of clinically meaningful biomarkers, and adapting laboratory discoveries into approaches that can be evaluated in humans or in settings closely mirroring clinical care.
What does "pilot and feasibility" mean for applicant projects?
The focus on feasibility suggests projects were meant to answer practical early questions such as whether recruitment is realistic, whether an intervention can be delivered as planned, whether measurements and outcomes can be captured reliably, and whether signals or effect sizes are strong enough to justify a larger trial or study.
What NIH mission area or program category did this align with?
The opportunity aligned with the NIH mission area referenced under CFDA 93.847, "Diabetes, Digestive, and Kidney Diseases Extramural Research."
What was the funding instrument for PA-15-317?
The listing identifies the funding instrument as a grant.
What was the award ceiling for this opportunity?
The listing shows an award ceiling of $200,000.
Was cost sharing or matching required?
No. The opportunity did not require cost sharing or matching.
Who was eligible to apply?
Eligibility was broad and included many U.S.-based organization types, such as public and state-controlled institutions of higher education, private institutions of higher education, nonprofits with or without 501(c)(3) status (other than institutions of higher education), small businesses, and other for-profit entities (including those other than small businesses).
Were government entities eligible to apply?
Yes. Eligible governmental entities included state governments, county governments, city or township governments, special district governments, independent school districts, and public housing authorities or Indian housing authorities. Certain eligible agencies of the federal government were also included.
Did the eligibility list include capacity-building or mission-driven institution types?
Yes. The listing explicitly included Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs). It also included faith-based or community-based organizations and regional organizations.
Were foreign (non-U.S.) institutions eligible to apply?
No. The program drew a clear boundary around foreign participation: non-U.S. (foreign) institutions were not eligible to apply.
Could a U.S. organization apply if it had a non-U.S. component?
No. Non-U.S. components of U.S. organizations were not eligible under this opportunity.
Were foreign components allowed under NIH policy for this FOA?
No. Foreign components (as defined by NIH policy) were not allowed.
What funding activity category was associated with this opportunity?
The listing classified the funding activity category as food and nutrition/health, consistent with NIH biomedical and clinical research connected to digestive health, metabolism, and nutrition-related factors.
When was PA-15-317 posted?
The opportunity was posted (and created) on July 31, 2015.
What was the closing date for applications?
The original and current closing date shown in the listing was September 7, 2018.
When was the opportunity archived?
The archive date listed was October 8, 2018.
Is PA-15-317 still active?
No. Based on the closing and archive dates provided, the FOA is no longer active for new submissions under that specific announcement.
If PA-15-317 is closed, what should prospective applicants do instead?
The listing indicates that prospective applicants would typically need to look for a reissued FOA, a related active NIH funding announcement, or current NIH/NIDDK R21 options that match the same scientific intent.
Which agency sponsored this opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
Where were applicants directed for the full announcement details?
Administrative details in the listing pointed applicants to the full announcement on the NIH Grants Guide website.
Who was listed as a contact for access or linking issues?
The listing provided a general NIH Office of Extramural Research (OER) webmaster contact for access or linking issues.
What was the overall intent of this grant program?
The overall intent was to help investigators move promising digestive and liver disease clinical and translational concepts from an idea or early data stage into a position where they could compete for larger, later-phase clinical or translational funding.
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| Understanding the Pathogenesis and Etiology of Type 1 Diabetes Using Biosamples and Subjects from Clinical Studies (DP3) Apply for RFA DK 15 018 Funding Number: RFA DK 15 018 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $1,600,000 |
| Urological Epidemiology (UroEpi) Institutional Research Career Development Program (K12) Apply for RFA DK 15 007 Funding Number: RFA DK 15 007 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Urological Epidemiology (UroEpi) Research Training Program (T32) Apply for RFA DK 15 008 Funding Number: RFA DK 15 008 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| NIDDK Cooperative Hematology Specialized Core Centers (U54) Apply for RFA DK 15 021 Funding Number: RFA DK 15 021 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $650,000 |
| Urinary Stone Disease Research Network Scientific Data Research Center (USDRN SDRC) (Collaborative U01) Apply for RFA DK 15 005 Funding Number: RFA DK 15 005 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $700,000 |
| Urinary Stone Disease Research Network Clinical Centers (USDRN CCs) (Collaborative U01) Apply for RFA DK 15 004 Funding Number: RFA DK 15 004 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $450,000 |
| Behavioral Health Economics Research Program Apply for BHER 001 Funding Number: BHER 001 Agency: Economic Research Service Category: Food and Nutrition Health Funding Amount: $30,000 |
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| Secondary Analyses in Obesity, Diabetes, Digestive and Kidney Diseases (R21) Apply for PA 06 151 Funding Number: PA 06 151 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
| Small Grant Program for NIDDK K08/K23 Recipients (R03) Apply for PAR 06 172 Funding Number: PAR 06 172 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $50,000 |
| Pilot And Feasibility Clinical Research Studies In Digestive Diseases And Nutrition Apply for PA 06 301 Funding Number: PA 06 301 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: $200,000 |
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| Proteomics Diabetes, Obesity, And Endocrine, Digestive, Kidney, Urologic, And Hematologic Diseases (R01) Apply for PA 07 016 Funding Number: PA 07 016 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Ancillary Studies to Major Ongoing NIDDK and NHLBI Clinical Research Studies (R01) Apply for PAR 07 024 Funding Number: PAR 07 024 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Non Invasive Methods for Diagnosis and Progression of Diabetes, Kidney, Urological, Hematological and Digestive Diseases (R01) Apply for PA 07 025 Funding Number: PA 07 025 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
| Health Disparities in NIDDK Diseases (R01) Apply for PA 07 027 Funding Number: PA 07 027 Agency: National Institutes of Health Category: Food and Nutrition Health Funding Amount: Case Dependent |
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