Opportunity Information: Apply for PAR 06 355
Apply for PAR 06 355
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Building Translational Research in Integrative Behavioral Science (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242 Mental Health Research Grants 93.273 Alcohol Research Programs 93.279 Drug Abuse and Addiction Research Programs.
- This funding opportunity was created on Dec 5, 2008 and posted on Apr 13, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: Private institutions of higher education Special district governments County governments For profit organizations other than small businesses Independent school districts State governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Public and State controlled institutions of higher education.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government are eligible to apply. Faith based or community based organizations Indian/Native American Tribal Government (Federally Recognized) Indian/Native American Tribal Government (Other than Federally Recognized) Indian/Native American Tribally Designated Organization
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Opportunity Summary:
Building Translational Research in Integrative Behavioral Science (R21) is an NIH grant opportunity designed to push basic behavioral science findings into practical, clinically meaningful research on mental and behavioral disorders. The main idea is to bring together teams that do not always work closely: on one side, scientists focused on fundamental behavioral processes (for example, learning, decision-making, attention, self-regulation, stress responses, social behavior), and on the other side, researchers and practitioners focused on the real-world problems of etiology, diagnosis, treatment, prevention, and service delivery for mental illness and behavioral disorders, including alcohol and drug use disorders. The FOA is meant to strengthen two-way translation: using basic behavioral theory and methods to reduce illness burden, and also using clinical and disorder-focused research to refine and deepen basic understanding of how behavioral processes change when affected by psychiatric, substance use, and related behavioral conditions.
This program is issued jointly by the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It reflects a larger, long-term commitment by these institutes to build sustained translational partnerships that connect laboratory-based behavioral science with applied research that can improve outcomes for patients and communities. Projects are expected to be integrative and translational in nature, meaning they should do more than simply run parallel basic and clinical studies. Competitive applications typically make a clear case for how basic behavioral concepts or tools will be adapted, tested, or extended in disorder-relevant contexts, and how findings from those contexts will feed back into stronger behavioral theory, measurement, or mechanistic understanding.
The funding mechanism is the NIH R21 exploratory/developmental grant, which is intended for early-stage, high-impact, and potentially higher-risk projects that generate foundational data, proof-of-concept findings, or new collaborative directions. The maximum project period is two years. Budget limits are up to $275,000 in total direct costs over the two-year period, with no more than $200,000 in direct costs in any single year. The FOA notes that the actual number of awards and total dollars awarded depend on the volume of applications, scientific merit, overall quality, requested budgets and durations, and the funds available across the participating NIH institutes.
This R21 announcement runs in parallel with a companion FOA with the same scientific scope using the R24 mechanism (Resource-Related Research Project Grant). In practice, that signals NIH interest in both short, exploratory translational projects (R21) and larger resource-building or infrastructure-oriented efforts (R24), depending on what applicants propose and what best fits their goals.
Eligibility is broad. A wide range of applicant organizations can apply, including public or private universities and colleges, hospitals, laboratories, nonprofit and for-profit organizations, community-based organizations, state and local government entities, eligible federal agencies, and Indian/Native American tribal governments and tribally designated organizations (both federally recognized and other than federally recognized). The source information also indicates that foreign institutions are eligible to apply, which is not always the case for every NIH opportunity. There is no cost sharing or matching requirement.
For project leadership, any individual with the expertise, resources, and institutional support needed to carry out the proposed work may serve as Project Director/Principal Investigator (PD/PI). NIH emphasizes inclusive participation, explicitly encouraging applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities. Applicants are allowed to submit more than one application as long as each submission is scientifically distinct. As with standard NIH practice, applications are assigned to NIH Institutes and Centers according to Public Health Service referral guidelines and institute program interests, which matters because fit with NIMH, NIDA, or NIAAA priorities can influence where the application is reviewed and ultimately considered for funding.
Administrative details in the listing identify the opportunity as discretionary grant funding from the National Institutes of Health, with activity areas spanning mental health research, alcohol research, and drug abuse and addiction research (CFDA numbers 93.242, 93.273, and 93.279). The opportunity used multiple receipt dates rather than a single deadline, and the historical record shows it was originally posted April 13, 2006, with an archive date of June 1, 2009. The full announcement was hosted through the NIH Grants Guide under PAR-06-355.
FAQs: Building Translational Research in Integrative Behavioral Science (R21) (PAR-06-355)
What is this funding opportunity?
Building Translational Research in Integrative Behavioral Science (R21) is an NIH grant opportunity intended to move basic behavioral science findings into practical, clinically meaningful research focused on mental and behavioral disorders, including alcohol and drug use disorders.
What is the main purpose of the program?
The program is designed to strengthen two-way translation between basic behavioral science and real-world clinical and disorder-focused research. It supports projects that (1) apply basic behavioral theory and methods to reduce illness burden and (2) use findings from disorder-relevant contexts to refine behavioral theory, measurement, and mechanistic understanding.
What does "integrative and translational" mean in this FOA?
Projects are expected to be more than parallel basic and clinical studies. Competitive applications typically show how basic behavioral concepts, tools, or methods will be adapted, tested, or extended in disorder-relevant contexts, and how results from those contexts will feed back into improved basic understanding (for example, stronger theory, better measures, or clearer mechanisms).
What types of research teams is NIH trying to bring together?
The FOA emphasizes collaboration between (a) scientists studying fundamental behavioral processes and (b) researchers and practitioners working on etiology, diagnosis, treatment, prevention, and service delivery related to mental illness and behavioral disorders.
What examples of "basic behavioral processes" are mentioned?
The FOA provides examples such as learning, decision-making, attention, self-regulation, stress responses, and social behavior.
What problem areas or conditions are within scope?
The scope includes mental illness and behavioral disorders broadly, explicitly including alcohol and drug use disorders, and related behavioral conditions where psychiatric or substance use issues may alter behavioral processes.
Which NIH institutes participate in this opportunity?
This program is issued jointly by the National Institute of Mental Health (NIMH), the National Institute on Drug Abuse (NIDA), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What funding mechanism is used?
The FOA uses the NIH R21 exploratory/developmental grant mechanism, intended for early-stage, high-impact, and potentially higher-risk projects that generate foundational data, proof-of-concept results, or new collaborative directions.
How long can an R21 project last under this FOA?
The maximum project period is two years.
What are the budget limits?
Applicants may request up to $275,000 in total direct costs over the two-year period, with no more than $200,000 in direct costs in any single year.
Is cost sharing or matching required?
No. The opportunity states there is no cost sharing or matching requirement.
How many awards will NIH make?
The FOA indicates that the number of awards and total dollars depend on factors such as application volume, scientific merit, overall quality, requested budgets and durations, and available funds across the participating institutes.
Who is eligible to apply?
Eligibility is broad and includes public or private universities and colleges, hospitals, laboratories, nonprofit and for-profit organizations, community-based organizations, state and local government entities, eligible federal agencies, and Indian/Native American tribal governments and tribally designated organizations (both federally recognized and other than federally recognized).
Are foreign institutions eligible?
Yes. The source information indicates that foreign institutions are eligible to apply under this opportunity.
Who can serve as Project Director/Principal Investigator (PD/PI)?
Any individual with the expertise, resources, and institutional support necessary to carry out the proposed work may serve as PD/PI.
Does the FOA encourage applications from specific groups?
Yes. NIH explicitly encourages applications from individuals from underrepresented racial and ethnic groups and from individuals with disabilities.
Can an organization or investigator submit more than one application?
Yes. Applicants may submit more than one application as long as each application is scientifically distinct.
How are applications assigned within NIH?
Applications are assigned to NIH Institutes and Centers according to Public Health Service referral guidelines and institute program interests. This matters because fit with NIMH, NIDA, or NIAAA priorities can influence where the application is reviewed and considered for funding.
Is there a related or companion funding opportunity?
Yes. This R21 FOA runs in parallel with a companion FOA with the same scientific scope that uses the R24 mechanism (Resource-Related Research Project Grant). This signals interest in both short, exploratory translational projects (R21) and larger resource-building or infrastructure-oriented efforts (R24).
What is the activity area or subject matter classification for this opportunity?
The listing identifies discretionary grant funding from NIH with activity areas spanning mental health research, alcohol research, and drug abuse and addiction research.
What CFDA numbers are associated with the opportunity?
The CFDA numbers listed are 93.242, 93.273, and 93.279.
Does the opportunity have a single deadline?
No. The opportunity used multiple receipt dates rather than a single deadline.
What is the FOA identifier and where was it posted?
The full announcement was posted through the NIH Grants Guide under PAR-06-355.
When was this opportunity originally posted and when was it archived?
The historical record shows it was originally posted on April 13, 2006, and has an archive date of June 1, 2009.
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Applicants also applied for:
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| In vivo Cancer Imaging Exploratory/Developmental Grants (R21) Apply for PA 06 371 Funding Number: PA 06 371 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
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| Developmental Projects in Complementary Approaches to Cancer Care (R21) Apply for PA 06 400 Funding Number: PA 06 400 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Studies of Energy Balance and Cancer in Humans (R21) Apply for PA 06 405 Funding Number: PA 06 405 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Phased Innovation Research in Cancer Prognosis and Prediction (R21/R33) Apply for PA 06 434 Funding Number: PA 06 434 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Phase II Developmental Research in Cancer Prognosis and Prediction (R33) Apply for PA 06 435 Funding Number: PA 06 435 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| The Development of Frontal Cortex and Limbic System and their roles in Drug Abuse or Mental Health (R21) Apply for PA 06 445 Funding Number: PA 06 445 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Drug Abuse Dissertation Research Epidemiology, Prevention, Treatment, Services, and Women and Sex/Gender Differences (R36) Apply for PAR 06 476 Funding Number: PAR 06 476 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Behavioral and Integrative Treatment Development Program (R21) Apply for PA 06 487 Funding Number: PA 06 487 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Behavioral and Integrative Treatment Development Program (R03) Apply for PA 06 488 Funding Number: PA 06 488 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R21) Apply for PA 06 496 Funding Number: PA 06 496 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Health Services Research on Practice Improvement Utilizing Community Treatment Programs within the National Drug Abuse Clinical Trials Network (CTN) (R03) Apply for PA 06 497 Funding Number: PA 06 497 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Exfoliated Cells and Circulating DNA in Cancer Detection and Diagnosis(R21) Apply for PA 06 499 Funding Number: PA 06 499 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R03) Apply for PA 06 502 Funding Number: PA 06 502 Agency: National Institutes of Health Category: Education Health Funding Amount: $50,000 |
| Pathophysiology of Bisphosphonates associated Osteonecrosis of the Jaw (R21) Apply for PA 06 501 Funding Number: PA 06 501 Agency: National Institutes of Health Category: Education Health Funding Amount: $200,000 |
| National Cancer Institute (NCI) Cancer Education and Career Development Program (R25) Apply for PAR 06 511 Funding Number: PAR 06 511 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R21) Apply for PA 06 461 Funding Number: PA 06 461 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R33) Apply for PA 06 462 Funding Number: PA 06 462 Agency: National Institutes of Health Category: Education Health Funding Amount: $500,000 |
| Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (Phased Innovation Award R21/R33) Apply for PA 06 463 Funding Number: PA 06 463 Agency: National Institutes of Health Category: Education Health Funding Amount: Case Dependent |
| Dissemination and Implementation Research in Health (R03) Apply for PAR 06 520 Funding Number: PAR 06 520 Agency: National Institutes of Health Category: Education Health Funding Amount: $250,000 |
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