Cancer Center Support Grants (CCSGs) for NCI designated Cancer Centers (P30) | Apply Online

Opportunity Summary:

The Cancer Center Support Grants (CCSGs) funding opportunity (P30 mechanism) is a National Cancer Institute (NCI), NIH program designed to support NCI-designated Cancer Centers through either new (competing) or renewal (competing) applications. The central idea is not to fund individual research projects, but to strengthen and organize an institution's overall cancer research enterprise by providing resources, infrastructure, and coordination that allow a cancer center to operate as a unified, high-impact hub for cancer discovery and translation.

This FOA supports two categories of NCI-designated centers. The first is the Comprehensive Cancer Center, which must show meaningful depth and breadth across three major scientific domains: laboratory research, clinical research, and population-based research. Beyond simply having activity in each area, comprehensive centers are expected to demonstrate substantial transdisciplinary work that bridges these domains, for example connecting basic mechanistic discoveries to clinical trials and to population-level prevention or outcomes research. The second category is the Cancer Center (non-comprehensive), which may focus primarily on laboratory research, clinical research, population science, or a combination of these components, without necessarily meeting the full breadth and bridging expectations required for comprehensive designation.

Across both center types, the purpose is to consolidate and elevate the institution's cancer research capabilities by integrating strong programs in laboratory, clinical, and population research (as applicable) into a single coordinated, transdisciplinary enterprise. A key emphasis is working across institutional and departmental boundaries so that the center functions as an organizing structure that aligns scientific priorities, promotes collaboration, and reduces fragmentation. In practical terms, CCSGs are meant to help cancer centers become major engines for understanding cancer biology and for developing better approaches to cancer prevention, diagnosis, and treatment.

The FOA also makes clear what is expected of centers supported by the P30 CCSG mechanism. These cancer centers should serve as major sources of discovery and innovation, and they are expected to make significant contributions through the development and maintenance of shared resources that support research across the center (for example, core facilities, shared technologies, or coordinated support services that multiple investigators rely on). In addition, centers are expected to collaborate and coordinate with other NCI-funded programs and investigators, which reinforces the idea that the cancer center should function as part of a broader national research ecosystem rather than as a standalone institution. Another explicit expectation is dissemination of research findings for community benefit, reflecting the public-facing responsibility of NCI-designated centers to ensure that scientific advances translate into real-world improvements.

From an administrative and funding standpoint, this opportunity uses the NIH center grant (P30) mechanism, and awards are discretionary and contingent on both the availability of federal funds and the receipt of a sufficient number of meritorious applications. There is no cost sharing or matching requirement listed. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, and nonprofit organizations (both with and without 501(c)(3) status), as specified in the opportunity details.

Key identification details from the listing include Funding Opportunity Number PAR-11-005, CFDA number 93.397 (Cancer Centers Support Grants), and an original posting date of October 12, 2010. The opportunity was later archived (archive date October 8, 2013), with closing dates listed in the record as September 7, 2013 (current closing at the time) and September 25, 2014 (original closing). Additional program details were provided through the NIH Grants Guide link associated with the FOA, and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.

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