Opportunity Information: Apply for RFA HL 11 032
Apply for RFA HL 11 032
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Utilization of a Human Lung Tissue Resource for Vascular Research (R03)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Oct 12, 2010 and posted on Oct 12, 2010.
- Applicants must submit their applications by Oct 14, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Independent school districts Public and State controlled institutions of higher education County governments Special district governments State governments Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) For profit organizations other than small businesses Public housing authorities/Indian housing authorities Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
Utilization of a Human Lung Tissue Resource for Vascular Research (R03) is a National Institutes of Health (NIH) funding opportunity (RFA-HL-11-032) focused on supporting smaller, targeted research projects that use human tissues and cells to answer important questions in vascular biology, with a strong emphasis on lung vascular disease. The central purpose is to speed up translational research, meaning studies that can help bridge the gap between basic laboratory findings and clinically relevant insights, particularly for conditions affecting the blood vessels of the lung.
A defining feature of this opportunity is access to human biospecimens collected through the Pulmonary Hypertension Breakthrough Initiative (PHBI). These biospecimens are intended to be the core resource for proposed projects, allowing investigators to work with human-derived material rather than relying only on animal models or synthetic systems. Applicants are encouraged to use these specimens to explore mechanistic questions in lung vascular biology, such as identifying or testing biological pathways that drive disease, clarifying how vascular remodeling occurs, or validating existing hypotheses about pulmonary arterial hypertension (PAH) pathogenesis. In practical terms, the program is designed to help researchers test whether ideas about PAH and related lung vascular disorders hold up when examined directly in human tissues and cells, which can strengthen the evidence base for future diagnostics, biomarkers, and therapeutic strategies.
While PAH and lung vascular disease are the main translational targets, the announcement also explicitly welcomes creative projects that use these same PHBI biospecimens to address broader vascular biology questions, as long as the work is still aligned with vascular research and makes strong scientific use of the resource. This leaves room for innovative approaches, including studies that might compare diseased and control tissues, investigate cell signaling and gene regulation in human vascular cells, examine inflammatory or metabolic contributions to vascular dysfunction, or apply new analytical methods to well-characterized human samples. The overall message is that NIH wants investigators to take advantage of a rare and valuable human lung tissue resource to generate evidence that is difficult to obtain by other means.
Administratively, this is a discretionary grant opportunity using the NIH R03 mechanism, which typically supports smaller-scope, shorter-duration projects compared with larger awards. The FOA was posted on October 12, 2010, with an original and final closing date of October 14, 2011, and it was archived on November 14, 2011. The estimated total funding level listed for the initiative is $1,500,000, and it does not require cost sharing or matching funds, which generally lowers barriers for applicants who may not have access to institutional matching resources.
Eligibility is broad and includes many types of organizations across the public, private, nonprofit, and educational sectors. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofits (both with and without 501(c)(3) status, other than institutions of higher education), small businesses, for-profit organizations other than small businesses, independent school districts, and multiple levels of government entities (state, county, city/township, special district). The FOA also recognizes additional eligible applicants such as federally recognized and other tribal governments and tribal organizations, Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), faith-based and community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies. This wide eligibility suggests the program was designed to encourage participation from diverse research environments, including institutions that serve underrepresented communities or operate in regions where specialized biomedical resources are less common.
For applicants looking for the full official details, NIH provided an additional information link to the full announcement page. NIH also listed the Office of Extramural Research (OER) webmaster contacts for technical issues accessing the opportunity online.
Frequently Asked Questions (FAQs)
What is the "Utilization of a Human Lung Tissue Resource for Vascular Research (R03)" opportunity?
It is a National Institutes of Health (NIH) funding opportunity announcement (FOA) identified as RFA-HL-11-032. It supports smaller, targeted research projects that use human tissues and cells to answer important questions in vascular biology, with a strong emphasis on lung vascular disease.
What is the main purpose of this NIH FOA?
The central purpose is to speed up translational research. In this context, that means research designed to help bridge basic laboratory findings and clinically relevant insights, particularly for diseases that affect the blood vessels of the lung.
What grant mechanism is used for this opportunity?
This opportunity uses the NIH R03 mechanism, which typically supports smaller-scope and shorter-duration projects compared with larger NIH awards.
What types of research projects is this FOA trying to support?
The FOA is intended to support focused projects in vascular biology that make strong scientific use of human tissues and cells. The program particularly encourages studies that can strengthen the evidence base for future diagnostics, biomarkers, and therapeutic strategies for lung vascular diseases.
What disease area is most strongly emphasized?
The announcement places a strong emphasis on lung vascular disease, including pulmonary arterial hypertension (PAH) as a key translational target.
What is the defining feature of this opportunity?
A defining feature is access to human biospecimens collected through the Pulmonary Hypertension Breakthrough Initiative (PHBI). These biospecimens are intended to be the core resource used in proposed projects.
Do proposed projects need to use PHBI biospecimens?
Based on the announcement description, PHBI biospecimens are intended to be the core resource for the proposed projects, and the FOA is designed around enabling investigators to work directly with human-derived material.
Why does NIH emphasize using human tissues and cells in this program?
The goal is to enable researchers to test ideas about PAH and related lung vascular disorders directly in human tissues and cells. This can help determine whether mechanistic hypotheses hold up in human-derived material, rather than relying only on animal models or synthetic systems.
What kinds of mechanistic questions could be addressed with these specimens?
The FOA highlights mechanistic work in lung vascular biology, such as identifying or testing biological pathways that drive disease, clarifying how vascular remodeling occurs, and validating existing hypotheses about PAH pathogenesis using human tissues and cells.
Are projects limited only to PAH?
No. While PAH and lung vascular disease are the main translational targets, the announcement also welcomes creative projects that use PHBI biospecimens to address broader vascular biology questions, as long as the work aligns with vascular research and makes strong scientific use of the resource.
What are examples of broader vascular biology topics that could fit, if they use PHBI biospecimens?
The description indicates that innovative approaches may include comparing diseased and control tissues, studying cell signaling and gene regulation in human vascular cells, examining inflammatory or metabolic contributions to vascular dysfunction, or applying new analytical methods to well-characterized human samples.
What is meant by "translational research" in this FOA?
In this FOA, translational research refers to studies intended to bridge the gap between basic laboratory findings and clinically relevant insights, particularly those that can inform understanding of lung vascular disease and support future development of diagnostics, biomarkers, or therapies.
How does this FOA aim to impact future diagnostics or treatments?
By encouraging researchers to validate mechanisms and hypotheses directly in human lung tissues and cells, the program aims to generate evidence that can strengthen the scientific foundation for future diagnostics, biomarkers, and therapeutic strategies.
What is the estimated total funding level for the initiative?
The estimated total funding level listed for the initiative is $1,500,000.
Is cost sharing or matching required?
No. The announcement specifies that cost sharing or matching funds are not required.
When was the FOA posted and when did it close?
The FOA was posted on October 12, 2010. The original and final closing date was October 14, 2011.
Is this funding opportunity still active?
No. The FOA was archived on November 14, 2011.
Who is eligible to apply?
Eligibility is broad and includes many organization types across public, private, nonprofit, and educational sectors, as well as small businesses, for-profit organizations (including those other than small businesses), independent school districts, and multiple levels of government entities.
Which higher education institutions are eligible?
Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education. The FOA also recognizes Alaska Native and Native Hawaiian Serving Institutions, Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, and Tribally Controlled Colleges and Universities (TCCUs).
Are nonprofit organizations eligible?
Yes. The FOA includes nonprofits with and without 501(c)(3) status (other than institutions of higher education) among eligible applicants.
Are small businesses and for-profit organizations eligible?
Yes. The eligibility list includes small businesses and for-profit organizations other than small businesses.
Are government entities eligible to apply?
Yes. The FOA includes multiple levels of government entities, including state governments, county governments, city or township governments, and special district governments. It also notes that eligible federal agencies may apply.
Are tribal governments and tribal organizations eligible?
Yes. The FOA recognizes federally recognized tribal governments, other tribal governments, and tribal organizations as eligible applicants.
Are U.S. territories and regional organizations included in eligibility?
Yes. The FOA includes U.S. territories or possessions and regional organizations among eligible applicants.
Are faith-based and community-based organizations eligible?
Yes. The FOA explicitly includes faith-based and community-based organizations.
Where can applicants find the official full details of the opportunity?
NIH provided an additional information link to the full announcement page for the official details.
Who should be contacted for technical issues accessing the opportunity online?
NIH listed the Office of Extramural Research (OER) webmaster contacts for technical issues related to accessing the opportunity online.
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