Opportunity Information: Apply for RFA CA 09 025
Apply for RFA CA 09 025
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Cancer Intervention and Surveillance Modeling Network (CISNET) (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control.
- This funding opportunity was created on Jun 25, 2009 and posted on Jun 25, 2009.
- Applicants must submit their applications by Nov 3, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,400,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Private institutions of higher education Small businesses.
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Non domestic (non U.S.) Entities (Foreign Organizations) U.S. Territory or Possession Units of Local Governments
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Opportunity Summary:
The Cancer Intervention and Surveillance Modeling Network (CISNET) (U01) funding opportunity (RFA-CA-09-025) is a National Cancer Institute (NCI) cooperative agreement aimed at supporting teams that use simulation and related modeling approaches to answer practical cancer control questions. The core intent is twofold: first, to quantify and explain how major cancer control interventions such as screening, treatment advances, and prevention efforts have shaped national cancer incidence and mortality trends over time; and second, to translate modeling evidence into guidance that can help decision-makers choose the most efficient mix of existing and emerging technologies and strategies at national, regional, or local levels. In other words, the program is designed to connect real-world data and policy-relevant questions through rigorous modeling so that the public health impact of different interventions can be compared and prioritized.
This FOA continues and expands CISNET work in the four long-standing cancer sites (prostate, lung, colorectal, and breast) and adds two additional sites: cervical cancer and esophageal cancer. Beyond adding new organ sites, the announcement also encourages applicants to broaden CISNET into additional modeling areas identified within the FOA, as long as the work remains anchored in the program's comparative, intervention-focused mission. A defining feature is that projects are expected to cover a broad range of cancer control issues relevant to the chosen cancer site, rather than focusing narrowly on a single question, so that results can meaningfully inform planning and resource allocation.
The program emphasizes comparative modeling, meaning multiple modeling groups work in parallel on aligned questions and then compare results across models. This cross-model comparison is a central requirement, intended to reveal which conclusions are robust across different modeling structures and assumptions and where uncertainty remains. Because that type of work requires both breadth and coordinated effort, the FOA anticipates that each award will typically include collaboration among roughly two to five modeling groups. The structure is described as collaborative and interactive, reflecting an expectation of ongoing coordination among funded investigators and with NCI under the cooperative agreement format.
Applicants are allowed to apply existing models to new questions, extend models, or merge models, but the FOA explicitly does not support de novo model development. That limitation signals that the NCI is prioritizing immediate, decision-relevant analyses and comparisons built on established modeling platforms rather than funding the creation of brand-new models from scratch. The competition is open to all qualified investigators, regardless of whether they have participated in CISNET previously, which frames this as both a continuation of a known network and an opportunity for new teams with suitable capabilities to join.
Administratively, this is a discretionary funding opportunity using the NIH U01 cooperative agreement mechanism, which typically implies substantial programmatic involvement by the NIH compared with a standard research grant. The FOA listed an expectation of six awards and an estimated total funding level of $5.4 million. There is no cost sharing or matching requirement. The posting date and creation date were June 25, 2009, with an original and current closing date of November 3, 2009, and an archive date of December 4, 2009.
Eligibility is broad and includes public and private institutions of higher education, nonprofits with or without 501(c)(3) status (with the noted exclusions in the listing), for-profit organizations other than small businesses, small businesses, state governments, units of local government, U.S. territories or possessions, eligible federal agencies, and non-U.S. (foreign) organizations. The opportunity is associated with multiple CFDA program areas spanning cancer cause and prevention, detection and diagnosis, treatment, biology, and control (93.393, 93.394, 93.395, 93.396, 93.399), reflecting the cross-cutting nature of intervention and surveillance modeling. For full details, NCI provided an additional information link to the NIH grants guide page for RFA-CA-09-025, and NIH Office of Extramural Research contact points were listed for technical access issues.
Frequently Asked Questions (FAQs): Cancer Intervention and Surveillance Modeling Network (CISNET) (U01) - RFA-CA-09-025
What is this funding opportunity?
This opportunity is the National Cancer Institute (NCI) Cancer Intervention and Surveillance Modeling Network (CISNET) (U01) funding opportunity, RFA-CA-09-025. It uses the NIH U01 cooperative agreement mechanism to support teams that apply simulation and related modeling approaches to practical cancer control questions.
What is the main purpose of CISNET under this FOA?
The FOA has two core purposes: (1) to quantify and explain how major cancer control interventions (such as screening, treatment advances, and prevention efforts) have influenced national cancer incidence and mortality trends over time, and (2) to translate modeling evidence into guidance that helps decision-makers select efficient combinations of existing and emerging technologies and strategies at national, regional, or local levels.
What types of questions is the program meant to address?
The program is designed to connect real-world data to policy-relevant questions through rigorous modeling. The intent is to compare, prioritize, and assess the public health impact of different cancer control interventions and strategies.
Which cancer sites are included in this FOA?
This FOA continues and expands CISNET work in four long-standing cancer sites: prostate, lung, colorectal, and breast. It also adds two additional sites: cervical cancer and esophageal cancer.
Does the FOA allow applicants to propose additional modeling areas beyond these sites?
Yes. The announcement encourages applicants to broaden CISNET into additional modeling areas identified within the FOA, as long as the proposed work remains anchored in CISNET's comparative, intervention-focused mission.
Is CISNET focused on a single research question per award?
No. Projects are expected to cover a broad range of cancer control issues relevant to the chosen cancer site rather than focusing narrowly on a single question. The idea is to generate results that can inform planning and resource allocation in a meaningful way.
What does "comparative modeling" mean in this program?
Comparative modeling means that multiple modeling groups work in parallel on aligned questions and then compare results across models. Cross-model comparison is described as a central requirement intended to show which conclusions are robust across different modeling approaches and assumptions and where uncertainty remains.
Is cross-model comparison required?
Yes. Cross-model comparison is explicitly described as a central requirement of the program.
How many modeling groups are expected to collaborate on a typical award?
The FOA anticipates that each award will typically include collaboration among roughly two to five modeling groups.
What level of collaboration is expected among funded investigators?
The structure is described as collaborative and interactive, with an expectation of ongoing coordination among funded investigators and with NCI. This aligns with the cooperative agreement format (U01), which typically involves substantial NIH programmatic involvement compared with a standard research grant.
Can applicants use existing models?
Yes. Applicants are allowed to apply existing models to new questions, extend models, or merge models.
Does the FOA support building a brand-new model from scratch?
No. The FOA explicitly does not support de novo model development. The emphasis is on immediate, decision-relevant analyses and comparisons based on established modeling platforms.
Do applicants need to have participated in CISNET previously to apply?
No. The competition is open to all qualified investigators, regardless of whether they have participated in CISNET previously.
What funding mechanism is being used?
This is an NIH U01 cooperative agreement. It is described as a discretionary funding opportunity and implies substantial NIH (NCI) programmatic involvement.
How many awards does the FOA expect to make?
The FOA lists an expectation of six awards.
What is the estimated total funding level for this opportunity?
The FOA provides an estimated total funding level of $5.4 million.
Is cost sharing or matching required?
No. The FOA states there is no cost sharing or matching requirement.
When was this FOA posted and when did it close?
The posting date and creation date were June 25, 2009. The original and current closing date was November 3, 2009. The archive date was December 4, 2009.
Who is eligible to apply?
Eligibility is broad. It includes public and private institutions of higher education; nonprofits with or without 501(c)(3) status (with noted exclusions in the listing); for-profit organizations other than small businesses; small businesses; state governments; units of local government; U.S. territories or possessions; eligible federal agencies; and non-U.S. (foreign) organizations.
Are non-U.S. (foreign) organizations eligible?
Yes. Non-U.S. (foreign) organizations are included in the eligibility list.
Which federal agency is sponsoring this opportunity?
The sponsoring institute is the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH).
What CFDA program areas are associated with this opportunity?
The opportunity is associated with multiple CFDA program areas spanning cancer cause and prevention, detection and diagnosis, treatment, biology, and control. The CFDA numbers listed are 93.393, 93.394, 93.395, 93.396, and 93.399.
Where can applicants find the official FOA details?
NCI provided an additional information link to the NIH grants guide page for RFA-CA-09-025.
Who is listed for help with technical access issues?
NIH Office of Extramural Research contact points were listed for technical access issues.
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