Opportunity Information: Apply for W81XWH 09 PRCRP CTS
Apply for W81XWH 09 PRCRP CTS
- The Dept. of the Army USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Peer Reviewed Cancer Collaborative Translational Science Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420 Military Medical Research and Development.
- This funding opportunity was created on Aug 29, 2009 and posted on Jun 25, 2009.
- Applicants must submit their applications by Dec 9, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $3,400,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The DoD Peer Reviewed Cancer Research Program (PRCRP) Collaborative Translational Science Award (FY09) is a Department of the Army funding opportunity designed to push melanoma and other skin cancer research toward real clinical use, specifically for service members and their families who have been deployed to environments with high exposure risk. The central goal is to speed up translation by pairing clinicians and laboratory scientists in tightly integrated collaborations so that promising observations from the lab, the clinic, or population studies can be advanced into practical tools for patient care. The announcement makes it clear that the program is narrowly focused: no topic areas outside melanoma and other skin cancers tied to high-exposure deployments are allowed, and applications are evaluated heavily on how directly they fit the stated Focus Areas and how convincingly they explain military relevance.
The opportunity restricts submissions to two Focus Areas. The first concentrates on understanding the molecular and immunological effects of ultraviolet (UV) exposure, both at the cellular level and at the level of the human host. This can include mechanistic work on how UV damages cells, alters immune surveillance, or influences tumor initiation and progression in ways that matter clinically. The second Focus Area targets genetic epidemiology and susceptibility, meaning research that clarifies inherited or population-level risk factors that increase the likelihood of melanoma and related skin cancers, especially in the context of deployment-associated exposures. Applicants are expected to explicitly connect their hypothesis and approach to these areas and to the military deployment context; the burden is on the research team to spell out why the work matters for the armed forces rather than leaving reviewers to infer it.
A defining feature of this mechanism is the required collaborative structure. Projects must be led by a team of two or three independent investigators (referred to as partners) whose combined expertise makes the work possible in a way that would be difficult to achieve if each partner worked separately. At least one partner must bring direct experience in melanoma or other skin cancer research or in the clinical care of melanoma or skin cancer patients. The collaboration must be balanced in a meaningful way: the announcement emphasizes that all partners should have equal intellectual input into the research design and execution. Proposals where one person merely provides tissue samples, data access, or a patient pipeline without true scientific co-leadership do not meet the intent of the award and are unlikely to be competitive.
From a research scope standpoint, the award supports translational work that can plausibly move an insight toward clinical application. The source of the initial observation can be a laboratory discovery, clinician experience with patients (including anecdotal patterns that merit systematic testing), or population-based findings. Supported activities include preclinical studies using animal models, studies involving human subjects and/or human anatomical substances, correlative studies linked to an existing clinical trial, and projects aimed at developing clinical endpoints that can be used in clinical trials. A recurring expectation is bidirectional translation: the research plan should show a real "bench to bedside and bedside to bench" exchange, where clinical realities shape the lab questions and laboratory results feed back into clinically actionable next steps.
Administratively, the funding opportunity number is W81XWH-09-PRCRP-CTS and it was offered as a discretionary program using a Cooperative Agreement or Grant mechanism under CFDA 12.420 (Military Medical Research and Development). The posting date was June 25, 2009, with an application closing date of December 9, 2009, and an archive date of January 8, 2010. The program anticipated making about three awards, with an estimated total funding level of $3.4 million, and it did not require cost sharing or matching. Eligibility is listed as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement. For applicants needing technical assistance, the announcement provides contact points for the CDMRP help desk and related support channels.
FAQs: DoD PRCRP Collaborative Translational Science Award (FY09)
What is the name of this funding opportunity?
The opportunity is the DoD Peer Reviewed Cancer Research Program (PRCRP) Collaborative Translational Science Award (FY09).
What is the opportunity number?
The funding opportunity number is W81XWH-09-PRCRP-CTS.
Which federal organization is offering this award?
This is a Department of the Army funding opportunity under the Department of Defense (DoD).
What is the main purpose of this award?
The central goal is to accelerate translational melanoma and other skin cancer research into real clinical use by supporting tightly integrated collaborations between clinicians and laboratory scientists.
Who is the research intended to benefit?
The announcement emphasizes relevance to service members and their families, particularly those deployed to environments with high exposure risk tied to melanoma and other skin cancers.
How narrow is the program scope?
The program is described as narrowly focused. Topic areas outside melanoma and other skin cancers tied to high-exposure deployments are not allowed.
How important is military relevance in the review?
Military relevance is heavily emphasized. Applications are evaluated strongly on how directly they fit the stated Focus Areas and how convincingly they explain military relevance, rather than leaving reviewers to infer it.
What Focus Areas are allowed under this opportunity?
Submissions are restricted to two Focus Areas:
- Understanding the molecular and immunological effects of ultraviolet (UV) exposure at both the cellular level and the level of the human host.
- Genetic epidemiology and susceptibility, including inherited or population-level risk factors for melanoma and related skin cancers, especially in the context of deployment-associated exposures.
What kinds of UV-related topics fit Focus Area 1?
Examples described include mechanistic work on how UV damages cells, alters immune surveillance, or influences tumor initiation and progression in clinically meaningful ways.
What kinds of topics fit Focus Area 2 (genetic epidemiology and susceptibility)?
This Focus Area supports research clarifying inherited or population-level risk factors that increase the likelihood of melanoma and related skin cancers, with an explicit connection to deployment-associated exposures.
Do applicants need to explicitly connect the project to deployment context?
Yes. Applicants are expected to clearly connect the hypothesis and approach to the Focus Area(s) and to the military deployment context, and to state why the work matters for the armed forces.
What is the required team structure for this award?
Projects must be led by a team of two or three independent investigators (partners) whose combined expertise enables work that would be difficult to accomplish if each partner worked separately.
Is melanoma or skin cancer expertise required on the team?
Yes. At least one partner must have direct experience in melanoma or other skin cancer research or in the clinical care of melanoma or skin cancer patients.
How does the program define a strong collaboration?
The collaboration is expected to be balanced and meaningful, with all partners having equal intellectual input into research design and execution.
Are “support-only” collaborators acceptable (for example, only providing samples or patient access)?
The announcement states that proposals where one person mainly provides tissue samples, data access, or a patient pipeline without true scientific co-leadership do not meet the intent of the award and are unlikely to be competitive.
What type of research is supported (basic, translational, clinical)?
The award supports translational work intended to plausibly move an insight toward clinical application, including projects bridging laboratory, clinical, and population-based observations.
Where can the initial observation for a project come from?
The starting point can be a laboratory discovery, clinician experience with patients (including anecdotal patterns that merit systematic testing), or population-based findings.
What specific study activities are allowed under this mechanism?
Supported activities described in the announcement include:
- Preclinical studies using animal models
- Studies involving human subjects and/or human anatomical substances
- Correlative studies linked to an existing clinical trial
- Projects aimed at developing clinical endpoints that can be used in clinical trials
What does the program mean by “bidirectional translation”?
The research plan is expected to show a real exchange between bench and bedside: clinical realities should shape laboratory questions, and laboratory results should feed back into clinically actionable next steps.
What funding mechanism is used for this opportunity?
The opportunity was offered as a discretionary program using a Cooperative Agreement or Grant mechanism.
What is the CFDA number associated with this program?
The CFDA number is 12.420, titled Military Medical Research and Development.
When was the opportunity posted?
The posting date was June 25, 2009.
What was the application closing date?
The application closing date was December 9, 2009.
When was the opportunity archived?
The archive date was January 8, 2010.
How many awards were expected to be made?
The program anticipated making about three awards.
What was the estimated total funding level?
The estimated total funding level was $3.4 million.
Is cost sharing or matching required?
No. The announcement states that cost sharing or matching was not required.
Who is eligible to apply?
Eligibility is listed as unrestricted (open to any type of entity), subject to any additional clarifications in the full announcement.
What are applications evaluated on most heavily?
Based on the announcement summary, applications are weighed heavily on (1) alignment to the two allowed Focus Areas and (2) how clearly and convincingly the project establishes military relevance tied to high-exposure deployments and melanoma/other skin cancers.
Where can applicants get technical assistance?
The announcement provides contact points for the CDMRP help desk and related support channels for applicants needing technical assistance.
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