Opportunity Information: Apply for RFA HL 11 015
Apply for RFA HL 11 015
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases Stage I(CADET I) (P50)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.838 Lung Diseases Research.
- This funding opportunity was created on Feb 26, 2010 and posted on Feb 26, 2010.
- Applicants must submit their applications by May 12, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $30,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- The number of recipients for this funding is limited to 30 candidate(s).
- Eligible applicants include: City or township governments Small businesses Special district governments Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Independent school districts Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) State governments County governments Native American tribal governments (Federally recognized).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases Stage I (CADET I) funding opportunity (RFA-HL-11-015) is a National Heart, Lung, and Blood Institute (NHLBI), NIH grant competition that supports the creation of clinical research centers focused on speeding up the development of new diagnostic tools and treatments for lung diseases and sleep-disordered breathing. The program is built around a translational idea: move discoveries grounded in basic disease mechanisms toward practical clinical use by using rational, pathobiology-driven strategies rather than trial-and-error development. In Stage I specifically, the emphasis is on exploring and vetting promising biological targets, then generating enough evidence to decide which targets are realistic candidates for mechanism-based approaches that could later become real-world modalities for prevention, diagnosis, or therapy.
CADET I is positioned as the front end of a two-stage program. Stage I funds the early clinical-center work needed to explore and validate targets, while a later Stage II (CADET II) will support more advanced development through separate, forthcoming companion announcements for additional Clinical Research Centers (CRCs) and a Data Coordinating Center (DCC). Those Stage II competitions are described as open competitions, and groups funded in CADET I are allowed to apply for Stage II CRC awards. In other words, CADET I can function as an on-ramp for teams that want to prove feasibility and readiness before competing for the next phase, but participation in Stage I does not appear to be the only route into Stage II.
The award mechanism is the NIH P50, which is typically used for specialized center programs. For CADET I, the total program funding is capped at 30 million dollars, contingent on appropriations and NHLBI availability. The agency anticipated making up to 30 awards, which signals an intent to fund a relatively broad set of centers pursuing diverse lung and sleep-related targets rather than a small number of very large centers.
In terms of project structure and budget, CADET I awards are short and focused. The project period is limited to 2 years. Applicants may request up to 300,000 dollars per year in direct costs (with the note that this limit is exclusive of indirect costs associated with consortia), for a maximum of 600,000 dollars in direct costs over the full two-year period. NHLBI also makes clear that actual award sizes may vary based on the proposed work, and that the final number of awards and total dollars will depend on application volume, scientific quality, project duration, and requested costs. Like most federal opportunities, awards are explicitly contingent on both available funds and a sufficient pool of highly meritorious applications.
Eligibility is broad and spans many organizational types that commonly participate in biomedical research and clinical translation. Eligible applicants include public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township), as well as special district governments and independent school districts. The eligibility language also highlights inclusion of specific institution types and community-serving organizations, such as historically Black colleges and universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), federally recognized and other tribal organizations, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. There is no cost sharing or matching requirement listed for this opportunity.
Administratively, the opportunity was posted February 26, 2010, with an original (and current) closing date of May 12, 2010, and an archive date of June 12, 2010. The program is associated with CFDA 93.838 (Lung Diseases Research) and falls under the health funding activity category. For full details, NIH provided an announcement link through the NIH Grants Guide, and technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs): CADET I (RFA-HL-11-015)
What is the CADET I funding opportunity?
CADET I stands for the Centers for Advanced Diagnostics and Experimental Therapeutics in Lung Diseases Stage I. It is an NHLBI (NIH) grant competition (RFA-HL-11-015) that supports creating clinical research centers focused on accelerating new diagnostic tools and treatments for lung diseases and sleep-disordered breathing.
What is the main goal of CADET I?
The main goal is to speed up development of new diagnostics and therapeutics by moving discoveries grounded in basic disease mechanisms toward practical clinical use, using rational, pathobiology-driven strategies rather than trial-and-error development.
What is the focus of Stage I specifically?
Stage I emphasizes exploring and vetting promising biological targets and generating enough evidence to determine which targets are realistic candidates for mechanism-based approaches that could later become real-world modalities for prevention, diagnosis, or therapy.
How does CADET I relate to CADET II?
CADET I is described as the front end of a two-stage program. Stage I funds early work to explore and validate targets, while a later Stage II (CADET II) is expected to support more advanced development through separate, forthcoming companion announcements for additional Clinical Research Centers (CRCs) and a Data Coordinating Center (DCC).
Do CADET I awardees have an advantage or special path into Stage II?
Groups funded in CADET I are allowed to apply for Stage II CRC awards. Stage II competitions are described as open competitions, and Stage I is positioned as an on-ramp for teams that want to prove feasibility and readiness before competing for the next phase. Participation in Stage I does not appear to be the only route into Stage II.
What NIH grant mechanism is used for CADET I?
The award mechanism is the NIH P50, which is typically used for specialized center programs.
How much total funding is available for the overall CADET I program?
Total program funding is capped at $30,000,000, contingent on appropriations and NHLBI availability.
How many awards does NHLBI expect to make?
NHLBI anticipated making up to 30 awards, indicating an intent to fund a broad set of centers pursuing diverse lung and sleep-related targets.
What is the project period for a CADET I award?
The project period is limited to 2 years.
What is the maximum budget allowed per year?
Applicants may request up to $300,000 per year in direct costs. The stated limit is exclusive of indirect costs associated with consortia.
What is the maximum budget allowed over the full project period?
The maximum is $600,000 in direct costs over the full two-year period.
Are all awards expected to be the same size?
No. NHLBI indicates award sizes may vary based on the proposed work. The final number of awards and total dollars will depend on application volume, scientific quality, project duration, and requested costs.
Is funding guaranteed once an application is submitted?
No. Like most federal opportunities, awards are contingent on available funds and on receiving a sufficient pool of highly meritorious applications.
Who is eligible to apply?
Eligibility is broad and includes: public and private institutions of higher education; nonprofit organizations (including 501(c)(3) and non-501(c)(3)); for-profit organizations (including small businesses and other for-profits); and multiple levels of government (state, county, city/township), as well as special district governments and independent school districts.
Are any specific institution types or community-serving organizations explicitly included?
Yes. The eligibility language highlights inclusion of HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), federally recognized and other tribal organizations, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions.
Is cost sharing or matching required?
No cost sharing or matching requirement is listed for this opportunity.
What research areas does this opportunity cover?
The opportunity is focused on lung diseases and sleep-disordered breathing, specifically supporting clinical research centers aiming to advance diagnostics and experimental therapeutics through translational, mechanism-informed approaches.
When was the opportunity posted and when does it close?
The opportunity was posted on February 26, 2010. The closing date is May 12, 2010.
What is the archive date?
The archive date is June 12, 2010.
What is the CFDA number associated with this opportunity?
The program is associated with CFDA 93.838 (Lung Diseases Research).
What is the funding activity category?
It falls under the health funding activity category.
Where were applicants directed for full details?
NIH provided an announcement link through the NIH Grants Guide for full details.
Who should be contacted for technical access issues related to the announcement?
Technical access issues were directed to the NIH Office of Extramural Research (OER) webmaster contact.
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