Opportunity Information: Apply for RFA DE 11 001
Apply for RFA DE 11 001
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborative Research on the Transition From Acute to Chronic Pain New Models and Measures in Clinical and Preclinical Pain Research (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Feb 26, 2010 and posted on Feb 26, 2010.
- Applicants must submit their applications by Jun 22, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Special district governments Public housing authorities/Indian housing authorities For profit organizations other than small businesses Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Independent school districts Native American tribal governments (Federally recognized) City or township governments Private institutions of higher education Public and State controlled institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
This funding opportunity, titled "Collaborative Research on the Transition From Acute to Chronic Pain: New Models and Measures in Clinical and Preclinical Pain Research (R01)" (Funding Opportunity Number RFA-DE-11-001), is an NIH grant announcement led by the National Institute of Dental and Craniofacial Research (NIDCR). It focuses on a central problem in pain medicine and neuroscience: why some people recover normally after an acute pain episode while others go on to develop persistent, disabling chronic pain. The core intent is to push the field toward a clearer, mechanistic understanding of the biological and behavioral factors that drive this transition, with the long-term practical aim of enabling earlier intervention and the creation of better treatments that stop acute pain from becoming chronic.
A major theme of the announcement is collaboration and multidisciplinary team science. The FOA is designed to bring together researchers with strong expertise in both basic (preclinical) and clinical pain research, while also pulling in specialists from outside the traditional pain field when their tools or concepts could unlock new progress. In practice, this could mean pairing clinicians who study patient pain trajectories with basic scientists working on neural circuits, immune signaling, or genetics, alongside collaborators from fields like computational biology, engineering, psychology, epidemiology, imaging, or biomarker discovery. The expectation is that these mixed teams will ask questions that cannot be answered well by a single discipline and will generate more innovative approaches than standard, siloed projects.
The FOA lays out three connected scientific objectives. First, it aims to assemble collaborative teams capable of pursuing novel, cross-cutting questions about how acute pain becomes chronic. Second, it calls for discovery-oriented work to identify the biological and behavioral mechanisms that actually drive the transition into a persistent dysfunctional pain condition, including risk factors that help explain individual differences in outcomes. Third, it emphasizes the development of improved models and measures of pain in both clinical and preclinical settings. This is a key point: the FOA is not only about describing pain outcomes, but also about creating or refining the experimental and clinical tools needed to detect, characterize, and predict the transition process. That can include new animal models that better reflect clinically relevant pain trajectories, more informative behavioral assays, improved phenotyping approaches in patients, and novel measurement strategies that can capture aspects of pain that are often missed by traditional scales.
The announcement explicitly encourages higher-risk projects, as long as the potential payoff is a genuine breakthrough. This signal matters because it suggests applicants can propose unconventional hypotheses, emerging technologies, or ambitious integrative designs, provided the overall plan is rigorous and the potential contribution to the field is substantial.
From a funding and administrative standpoint, the mechanism of support is the NIH R01 (research project grant). NIDCR planned to commit a total of $5,000,000 in total costs in fiscal year 2011 and anticipated making roughly 7 to 10 awards, depending on application quality and fund availability. The project period can be up to five years. While R01 budgets are not capped at a specific dollar amount in this announcement, budgets are expected to be well-justified and appropriate to the proposed scope of work.
The opportunity was posted February 26, 2010, with an original and current closing date of June 22, 2010, and an archive date of July 23, 2010. The activity category is Health, with CFDA 93.121 (Oral Diseases and Disorders Research), reflecting NIDCR's role and interests, though the scientific scope is framed broadly around pain transition mechanisms and measurement advances.
Eligibility is broad and includes many organization types: public and private institutions of higher education, nonprofits (including but not limited to 501(c)(3) organizations), for-profit organizations (other than small businesses, with small businesses also listed as eligible), local and state governments, tribal governments and tribal organizations, public housing authorities, independent school districts, and additional categories such as historically Black colleges and universities, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, faith-based or community-based organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities and regional organizations. There is no cost-sharing or matching requirement.
In short, this FOA is a targeted NIH R01 initiative intended to speed progress on one of the most consequential questions in pain research: the determinants of the shift from short-term pain to long-term chronic pain. It prioritizes collaborative, multidisciplinary science; encourages bold, potentially high-impact ideas; and seeks both mechanistic discoveries and better research models and measurement tools that can improve prediction, prevention, and treatment of chronic pain development.
Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The opportunity is titled "Collaborative Research on the Transition From Acute to Chronic Pain: New Models and Measures in Clinical and Preclinical Pain Research (R01)."
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-DE-11-001.
Which agency and NIH institute are leading this opportunity?
This is an NIH grant announcement led by the National Institute of Dental and Craniofacial Research (NIDCR).
What central research problem is this FOA trying to address?
The FOA focuses on why some people recover normally after an acute pain episode while others develop persistent, disabling chronic pain, and aims to improve mechanistic understanding of the biological and behavioral drivers of that transition.
What is the long-term practical goal of the research supported by this FOA?
The long-term aim is to enable earlier intervention and support the development of better treatments that can stop acute pain from becoming chronic.
What funding mechanism is being used?
The mechanism of support is the NIH R01 (research project grant).
How much funding was NIDCR planning to commit, and how many awards were expected?
NIDCR planned to commit a total of $5,000,000 in total costs in fiscal year 2011 and anticipated making about 7 to 10 awards, depending on application quality and availability of funds.
What is the maximum project period?
The project period can be up to five years.
Is there a specific budget cap for applications under this FOA?
No specific dollar cap is stated in the provided information. Budgets are expected to be well-justified and appropriate to the proposed scope of work.
What are the main scientific objectives of the FOA?
The FOA describes three connected objectives: (1) assembling collaborative teams to pursue cross-cutting questions about the transition from acute to chronic pain; (2) discovery-oriented research to identify biological and behavioral mechanisms and risk factors that drive the transition and explain individual differences; and (3) developing improved models and measures of pain in both clinical and preclinical settings.
Is collaboration required or strongly encouraged?
Collaboration and multidisciplinary team science are a major theme. The FOA is designed to bring together expertise in both basic (preclinical) and clinical pain research, and it also encourages participation by experts outside the traditional pain field when their methods could accelerate progress.
What kinds of disciplines or specialties does the FOA suggest bringing into collaborative teams?
In addition to clinical and basic pain research, the FOA examples include computational biology, engineering, psychology, epidemiology, imaging, and biomarker discovery, among other relevant areas.
Does the FOA support both clinical and preclinical research?
Yes. The announcement explicitly covers both clinical and preclinical pain research and stresses improved models and measures in both settings.
What does the FOA mean by developing "new models and measures"?
Based on the description provided, this includes efforts such as creating new animal models that better reflect clinically relevant pain trajectories, developing more informative behavioral assays, improving patient phenotyping approaches, and designing novel measurement strategies that capture aspects of pain that traditional scales may miss.
Is the FOA focused only on describing pain outcomes?
No. A stated emphasis is on creating or refining experimental and clinical tools needed to detect, characterize, and predict the transition process, alongside mechanistic discovery.
Are higher-risk projects allowed?
Yes. The FOA explicitly encourages higher-risk projects when the potential payoff could be a genuine breakthrough, as long as the plan is rigorous and the potential contribution is substantial.
What is the activity category and CFDA number listed for this opportunity?
The activity category is Health, and the CFDA number is 93.121 (Oral Diseases and Disorders Research).
When was the opportunity posted, and what were the key dates?
The opportunity was posted on February 26, 2010. The original and current closing date was June 22, 2010, and the archive date was July 23, 2010.
Is this opportunity still open based on the dates provided?
No. The closing date listed is June 22, 2010, and the FOA is shown as archived on July 23, 2010.
Who is eligible to apply?
Eligibility is broad and includes public and private institutions of higher education; nonprofit organizations (including 501(c)(3) entities); for-profit organizations (including small businesses, which are also listed as eligible); local and state governments; tribal governments and tribal organizations; public housing authorities; independent school districts; and a range of additional categories such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian serving institutions, faith-based and community-based organizations, U.S. territories or possessions, and non-U.S. (foreign) entities and regional organizations.
Are foreign (non-U.S.) organizations eligible?
Yes. Non-U.S. (foreign) entities and regional organizations are listed as eligible in the provided information.
Is cost sharing or matching required?
No. There is no cost-sharing or matching requirement.
What kind of research approach does the FOA prioritize?
The FOA prioritizes collaborative, multidisciplinary science that can answer questions not well addressed by a single discipline, with an emphasis on mechanistic discovery and better models and measurement tools to improve prediction and prevention of chronic pain development.
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