Opportunity Information: Apply for RFA DD 11 002
Apply for RFA DD 11 002
- The Centers for Disease Control and Prevention in the health sector is offering a public funding opportunity titled "Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Study to Explore Early Development (SEED) II (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.073 Birth Defects and Developmental Disabilities Prevention and Surveillance.
- This funding opportunity was created on Nov 18, 2010 and posted on Nov 18, 2010.
- Applicants must submit their applications by Jan 18, 2011 On time submission requires that applications be successfully submitted to Grants.gov and validated no later than 500 p.m. eastern time on the deadline date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $33,250,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $900,000.00 in funding.
- The number of recipients for this funding is limited to 6 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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Opportunity Summary:
The Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Study to Explore Early Development (SEED) II (U01) is a CDC funding opportunity designed to continue and expand a coordinated, multi-site research network focused on autism and related developmental disabilities. Structured as a cooperative agreement (U01), the program emphasizes active collaboration between the CDCs National Center on Birth Defects and Developmental Disabilities (NCBDDD) and the funded research sites, meaning the work is carried out with substantial federal scientific and programmatic involvement rather than as a fully independent investigator-initiated grant.
At its core, the opportunity supports two tightly linked efforts. First, it funds the continued operation of the CADDRE sites by sustaining their epidemiologic research capacity and enabling implementation of SEED Phase II. SEED is described as the primary collaborative activity of CADDRE and is built as a rigorous case-control study aimed at identifying genetic and environmental risk factors for autism. A defining feature of the SEED approach is its multiple-source, population-based ascertainment of both case and control groups, which is intended to strengthen representativeness and reduce bias by drawing participants from defined populations using more than one pathway to identify eligible children and families.
Second, the announcement provides support for continuation of the SEED Central Laboratory and Biosample Repository, along with implementation of reporting for SEED Phase II. This component signals that the study is not only collecting questionnaire or clinical data, but also managing centralized biospecimen handling and storage to support genetic, biomarker, and other laboratory-based analyses. Centralizing these functions helps standardize procedures across sites, improve quality control, and ensure that biosamples and associated data can be used consistently for pooled analyses and future research, subject to applicable rules and governance.
In terms of funding scale and structure, the CDC anticipated a total estimated funding amount of 33,250,000 across the life of the opportunity, with approximately 5,250,000 available in fiscal year 2011 to support six awards. The award ceiling is listed as 900,000, with no specified award floor. There is no cost sharing or matching requirement, which lowers barriers for applicants that may not have discretionary funds to contribute. The program falls under CFDA 93.073 (Birth Defects and Developmental Disabilities Prevention and Surveillance), aligning it with federal public health goals related to understanding, preventing, and monitoring developmental disabilities.
Eligibility is described as unrestricted (open to any type of entity), subject to clarifications in the full text of the announcement. This typically means a wide range of organizations could apply (for example, universities, nonprofits, research institutes, and certain governmental entities), provided they meet any detailed requirements laid out in the complete funding notice, such as demonstrated capacity to conduct population-based epidemiologic research, ability to recruit and evaluate participants, and readiness to follow standardized SEED protocols within a collaborative network.
Key administrative details include the Funding Opportunity Number RFA DD 11 002, a posted and creation date of November 18, 2010, and an application deadline of January 18, 2011. Applications were required to be submitted through Grants.gov and successfully validated by 5:00 p.m. Eastern Time on the deadline date, underscoring that both submission and system validation were necessary for on-time receipt. The opportunity was archived on February 17, 2011. For access issues or technical assistance related to the announcement, the listed contact was the CDC Procurement and Grants Office (PGO), Technical Information and Management Section (TIMS), reachable by phone at 770-488-2700.
Overall, this grant opportunity is best understood as an investment in maintaining a national, collaborative infrastructure for autism epidemiology and etiologic research, pairing field-based, population-grounded recruitment and phenotyping with centralized laboratory and biospecimen resources. The intent is to enable SEED Phase II to generate robust, comparable data across multiple sites so researchers can more effectively evaluate how genetic factors and environmental exposures may interact in early development and contribute to autism risk.
Frequently Asked Questions (FAQs)
What is the CADDRE SEED II (U01) funding opportunity?
This opportunity is a CDC cooperative agreement (U01) to continue and expand the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) network and to implement Study to Explore Early Development (SEED) Phase II. It is designed to support coordinated, multi-site research on autism and related developmental disabilities, with an emphasis on epidemiology and identifying genetic and environmental risk factors.
Which CDC program is associated with this opportunity?
The opportunity is associated with the CDC National Center on Birth Defects and Developmental Disabilities (NCBDDD), which is expected to have substantial scientific and programmatic involvement with funded sites.
What does it mean that this is a cooperative agreement (U01) instead of a traditional research grant?
As a U01 cooperative agreement, the work is carried out with substantial federal scientific and programmatic involvement. This means funded sites are expected to collaborate actively with CDC (NCBDDD) rather than operating as fully independent investigator-initiated projects.
What are the main components being funded?
The announcement supports two tightly linked efforts: (1) continued operation of the CADDRE sites to sustain epidemiologic research capacity and implement SEED Phase II, and (2) continuation of the SEED Central Laboratory and Biosample Repository, along with implementation of reporting for SEED Phase II.
What is SEED and what kind of study design does it use?
SEED (Study to Explore Early Development) is described as the primary collaborative activity of CADDRE. It is a rigorous case-control study intended to identify genetic and environmental risk factors for autism.
What is meant by "multiple-source, population-based ascertainment" in SEED?
It refers to identifying and recruiting both case and control groups from defined populations using more than one pathway (multiple sources). This approach is intended to strengthen representativeness and reduce bias compared with relying on a single recruitment source.
Does the opportunity involve biospecimens and lab analyses, or only questionnaires and clinical data?
It involves more than questionnaire or clinical data. The opportunity includes continuation of a Central Laboratory and Biosample Repository, indicating centralized biospecimen handling, storage, and support for genetic, biomarker, and other laboratory-based analyses.
Why is there a Central Laboratory and Biosample Repository?
Centralizing laboratory and repository functions is intended to standardize procedures across sites, improve quality control, and support consistent pooled analyses and future research use of biosamples and associated data, subject to applicable rules and governance.
How much funding was anticipated for this opportunity overall?
The CDC anticipated a total estimated funding amount of $33,250,000 across the life of the opportunity.
How much funding was available in fiscal year 2011 and how many awards were expected?
Approximately $5,250,000 was available in fiscal year 2011 to support six awards.
What was the award ceiling and was there an award floor?
The award ceiling was listed as $900,000, and there was no specified award floor.
Is cost sharing or matching required?
No. There is no cost sharing or matching requirement stated for this opportunity.
What is the CFDA number associated with this program?
The program falls under CFDA 93.073 (Birth Defects and Developmental Disabilities Prevention and Surveillance).
Who was eligible to apply?
Eligibility is described as unrestricted (open to any type of entity), subject to clarifications in the full text of the announcement. The description suggests that applicants would need the capacity to conduct population-based epidemiologic research, recruit and evaluate participants, and follow standardized SEED protocols in a collaborative network.
What is the Funding Opportunity Number?
The Funding Opportunity Number is RFA DD 11 002.
When was the opportunity posted and when was the application deadline?
The posted/creation date was November 18, 2010, and the application deadline was January 18, 2011.
How were applications required to be submitted?
Applications were required to be submitted through Grants.gov.
What does "successfully validated by 5:00 p.m. Eastern Time" mean for submission?
It means that submitting by the deadline was not enough on its own; the application also had to pass the Grants.gov system validation process by 5:00 p.m. Eastern Time on January 18, 2011 to be considered on time.
Is this funding opportunity still active?
No. The opportunity was archived on February 17, 2011.
Who could applicants contact for technical assistance with the announcement?
For access issues or technical assistance, the listed contact was the CDC Procurement and Grants Office (PGO), Technical Information and Management Section (TIMS), reachable by phone at 770-488-2700.
What is the overall purpose of investing in CADDRE and SEED Phase II?
The purpose is to maintain and strengthen a national collaborative infrastructure for autism epidemiology and etiologic research. The goal is to generate robust, comparable multi-site data and biospecimen resources to evaluate how genetic factors and environmental exposures may interact in early development and contribute to autism risk.
What types of activities were CADDRE sites expected to support under this opportunity?
Based on the description, sites were expected to sustain epidemiologic research capacity, implement SEED Phase II, recruit and evaluate participants from defined populations, and follow standardized protocols within a coordinated, multi-site network in active collaboration with CDC (NCBDDD).
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