Opportunity Information: Apply for RFA HS 11 004
Apply for RFA HS 11 004
- The Agency for Health Care Research and Quality in the health sector is offering a public funding opportunity titled "Centers for Education and Research on Therapeutics (CERTs)( U19)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.226 Research on Healthcare Costs, Quality and Outcomes.
- This funding opportunity was created on Mar 14, 2011 and posted on Mar 14, 2011.
- Applicants must submit their applications by May 18, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $5,100,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal governments (Federally recognized) County governments City or township governments Public and State controlled institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Eligible Agencies of the Federal Government Faith based or Community based Organizations Indian/Native American Tribal Governments (Other than Federally Recognized).
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Opportunity Summary:
The Centers for Education and Research on Therapeutics (CERTs) (U19) funding opportunity, issued by the Agency for Healthcare Research and Quality (AHRQ), supports the creation or continuation of multi-project research centers focused on improving how therapeutics are studied, used, and integrated into real-world care. It is offered as a cooperative agreement (U19), which means awardees are expected to work closely with AHRQ and other federal partners rather than operating with the lighter-touch oversight typical of standard research grants. The overall intent is to build research centers that can generate practical evidence and tools around therapeutics and help move that evidence into clinical practice and policy.
Applications must propose a coherent, theme-based research center that runs for a five-year project period and includes a set of 3 to 5 major projects. These projects need to be tied together by a unifying center theme and, as a portfolio, must address at least three of five program interest areas. The five areas are: (1) comparative effectiveness research (studying which treatments work best for which patients under real-world conditions), (2) patient safety (identifying, preventing, and mitigating harms related to therapeutics), (3) tool development, enhancement, and/or validation (creating or improving measurement methods, data tools, decision supports, or analytic approaches used in therapeutics research and safety), (4) health care system interventions (testing system-level changes that influence prescribing, monitoring, adherence, outcomes, costs, or safety), and (5) translation of research findings into practice or policy (dissemination and implementation strategies that actually change care delivery, payer policies, or regulatory and organizational practices). These priorities reflect shared interests across AHRQ, the Food and Drug Administration (FDA), the Centers for Medicare and Medicaid Services (CMS), and other stakeholders involved in therapeutics, coverage decisions, and quality of care.
A key expectation is that each funded center will not just conduct a set of studies, but also establish a durable core infrastructure that supports the proposed projects and enables additional work beyond the initial project list. In practice, that means applicants are expected to plan for resources such as data capabilities, analytic and methodological support, stakeholder engagement structures, education and dissemination capacity, and administrative coordination that can attract or support future projects with other partners and funding sources. The announcement explicitly encourages partnerships with people and organizations involved in clinical care or in financing care, such as health systems, clinician groups, payers, or similar entities, because those relationships make it more likely that findings will be relevant, feasible to implement, and positioned to influence real decisions.
Another defining requirement is that applicants must submit at least two concept briefs describing important cross-cutting issues in therapeutics that could be addressed collaboratively with other CERTs research centers. These briefs are meant to identify shared challenges or opportunities that benefit from coordination across the network rather than being solved by a single center alone. Examples of topics include common methodologies, improving the quality use of therapeutics, policy issues related to therapeutics research and education, building meaningful external partnerships, and dissemination and implementation of CERTs findings. These concept briefs help shape cross-CERTs committees and working groups and can also seed annual collaborative projects or activities supported through the CERTs Scientific Forum (www.certs.hhs.gov). In other words, the program is structured to create both strong individual centers and an active national network that tackles shared therapeutics problems together.
From an administrative standpoint, the opportunity is identified as Funding Opportunity Number RFA HS 11 004, titled "Centers for Education and Research on Therapeutics (CERTs) (U19)." It is categorized as discretionary funding, with a health-focused activity category, and is listed under CFDA 93.226 (Research on Healthcare Costs, Quality and Outcomes). There is no cost sharing or matching requirement. The posting and creation date were March 14, 2011, with an original and current closing date of May 18, 2011, and an archive date of June 18, 2011. The estimated total funding amount listed is $5,100,000.
Eligibility is broad and includes public and state-controlled institutions of higher education, private institutions of higher education, city or township governments, county governments, federally recognized Native American tribal governments, and other Native American tribal organizations. The announcement also notes additional eligible applicants such as eligible federal agencies and faith-based or community-based organizations, with further clarification referenced in the full funding announcement.
In short, this CERTs U19 opportunity is designed for teams that can mount a coordinated, multi-project therapeutics research agenda with strong infrastructure, meaningful real-world partnerships, and a clear plan to both produce evidence and move it into practice and policy. It also requires applicants to contribute to a larger networked program by proposing cross-center ideas that can evolve into shared working groups and collaborative projects.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity funds Centers for Education and Research on Therapeutics (CERTs) through a U19 cooperative agreement issued by the Agency for Healthcare Research and Quality (AHRQ). It supports the creation or continuation of multi-project research centers focused on improving how therapeutics are studied, used, and integrated into real-world care.
What does "U19 cooperative agreement" mean in this program?
The award mechanism is a cooperative agreement (U19), meaning funded centers are expected to work closely with AHRQ and other federal partners. This is described as more active collaboration and involvement than the lighter-touch oversight typical of standard research grants.
What is the overall goal of the CERTs program described here?
The goal is to build theme-based research centers that generate practical evidence and tools about therapeutics and help move that evidence into clinical practice and policy. The program is structured to support both strong individual centers and a coordinated national network across CERTs sites.
How long is the project period?
Applications must propose a research center that runs for a five-year project period.
How many research projects must be included in an application?
Each application must include a set of 3 to 5 major projects.
Do the projects need to be connected to each other?
Yes. The projects must be tied together by a unifying center theme and presented as a coherent, theme-based research center.
Are there required topic areas the center must address?
Yes. As a portfolio, the proposed projects must address at least three of five program interest areas identified in the announcement.
What are the five program interest areas?
- Comparative effectiveness research: studying which treatments work best for which patients under real-world conditions.
- Patient safety: identifying, preventing, and mitigating harms related to therapeutics.
- Tool development, enhancement, and/or validation: creating or improving measurement methods, data tools, decision supports, or analytic approaches used in therapeutics research and safety.
- Health care system interventions: testing system-level changes that influence prescribing, monitoring, adherence, outcomes, costs, or safety.
- Translation of research findings into practice or policy: dissemination and implementation strategies that change care delivery, payer policies, or regulatory and organizational practices.
Do applicants have to cover all five interest areas?
No. The requirement stated is that the overall portfolio addresses at least three of the five program interest areas.
Which federal partners and stakeholders are connected to these priorities?
The priorities are described as reflecting shared interests across AHRQ, the Food and Drug Administration (FDA), the Centers for Medicare and Medicaid Services (CMS), and other stakeholders involved in therapeutics, coverage decisions, and quality of care.
Is building center infrastructure an expectation, or just the individual studies?
Building durable core infrastructure is a key expectation. The center is expected not only to conduct a set of studies, but also to establish resources that support the proposed projects and enable additional work beyond the initial project list.
What kinds of infrastructure resources are encouraged or expected?
The announcement points to resources such as data capabilities, analytic and methodological support, stakeholder engagement structures, education and dissemination capacity, and administrative coordination.
Does the program encourage partnerships outside the applicant institution?
Yes. The announcement explicitly encourages partnerships with people and organizations involved in clinical care or in financing care, such as health systems, clinician groups, payers, or similar entities, to increase relevance and feasibility and to better position findings to influence real decisions.
Are applicants required to propose cross-center collaborative ideas?
Yes. Applicants must submit at least two concept briefs describing important cross-cutting issues in therapeutics that could be addressed collaboratively with other CERTs research centers.
What are the concept briefs intended to accomplish?
The concept briefs are intended to identify shared challenges or opportunities that benefit from coordination across the CERTs network rather than being solved by a single center alone. They help shape cross-CERTs committees and working groups and can seed annual collaborative projects or activities supported through the CERTs Scientific Forum.
What types of topics can be covered in the required concept briefs?
Examples given include common methodologies, improving the quality use of therapeutics, policy issues related to therapeutics research and education, building meaningful external partnerships, and dissemination and implementation of CERTs findings.
What is the CERTs Scientific Forum referenced in the announcement?
The CERTs Scientific Forum is identified as a place where annual collaborative projects or activities may be supported and is referenced with the website www.certs.hhs.gov.
What is the Funding Opportunity Number and title?
The opportunity is Funding Opportunity Number RFA HS 11 004, titled "Centers for Education and Research on Therapeutics (CERTs) (U19)."
How is this opportunity categorized?
It is categorized as discretionary funding with a health-focused activity category.
What CFDA number is associated with this opportunity?
The CFDA listing provided is 93.226, described as Research on Healthcare Costs, Quality and Outcomes.
Is there a cost sharing or matching requirement?
No. The information provided states there is no cost sharing or matching requirement.
What is the estimated total funding amount listed?
The estimated total funding amount listed is $5,100,000.
What are the key dates for this funding opportunity?
The posting and creation date is March 14, 2011. The original and current closing date is May 18, 2011. The archive date is June 18, 2011.
Who is eligible to apply?
Eligibility is described as broad and includes:
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- City or township governments
- County governments
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
Are any other types of organizations mentioned as eligible?
Yes. The announcement also notes additional eligible applicants such as eligible federal agencies and faith-based or community-based organizations, with further clarification referenced in the full funding announcement.
What kind of applicant team is this opportunity designed for?
It is designed for teams that can mount a coordinated, multi-project therapeutics research agenda with strong infrastructure, meaningful real-world partnerships, and a clear plan to both produce evidence and move it into practice and policy, while also contributing to a larger networked program through cross-center concept briefs.
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