Opportunity Information: Apply for RFA GM 10 005
Apply for RFA GM 10 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers for High Throughput Structure Determination (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Aug 12, 2009 and posted on Jul 31, 2009.
- Applicants must submit their applications by Oct 28, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $28,000,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $8,000,000.00 in funding.
- Eligible applicants include: City or township governments Public housing authorities/Indian housing authorities Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Small businesses Special district governments Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education State governments Independent school districts Private institutions of higher education For profit organizations other than small businesses Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments).
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Centers for High Throughput Structure Determination (U54) funding opportunity (RFA-GM-10-005) is a National Institutes of Health program, administered through the National Institute of General Medical Sciences (NIGMS), aimed at building a set of major production-style structural biology centers that can operate at true high-throughput scale. The core idea is to create the backbone of the PSIBiology network, a continuation and evolution of capabilities developed under earlier phases of the Protein Structure Initiative (PSI). These centers are expected to deliver industrial-strength structural determination pipelines, with an illustrative benchmark of roughly 200 macromolecular structures per year deposited into the Protein Data Bank (PDB). In practical terms, NIGMS is looking for groups that can run end-to-end structure determination as an efficient, repeatable workflow, not just occasional, investigator-driven structure projects.
A key feature of this opportunity is that it is built around networked, coordinated science rather than isolated center grants. Awarded principal investigators are expected to play an active governance and coordination role as members of the PSIBiology Network Steering Committee. That means successful applicants are not only providing capacity (people, instrumentation, automation, informatics, and standardized processes), but also committing to joint planning, shared decision-making, and regular interaction with other PSIBiology components and NIH staff. The intent is to have the centers collectively operate as a national-scale resource for high-throughput enabled structural biology, with priorities and operational practices shaped through the network rather than set by any one site.
The mechanism of support is a U54 cooperative agreement, which signals substantial NIH programmatic involvement compared with a standard research project grant. Under a cooperative agreement, NIH staff are expected to be engaged in coordinating interactions across the multiple moving parts of the PSIBiology effort, helping align goals, facilitating collaboration, and ensuring that the network functions as an integrated enterprise. Applicants should read this as an expectation that milestones, data sharing, coordination, and operational transparency will matter, and that the centers will need to work in a highly collaborative and accountable way.
From a funding and scale perspective, NIGMS indicated an estimated total of up to $28,000,000 available through this announcement, with an anticipated 3 to 5 awards. The award ceiling listed is $8,000,000, reflecting that these are intended to be large, infrastructure- and production-oriented center awards capable of sustaining high-throughput pipelines and delivering a significant annual output of deposited structures. There is no cost sharing or matching requirement noted.
Eligibility is broad and includes many organization types typically eligible for NIH funding, spanning public and private institutions of higher education, nonprofit organizations (including both 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district, and independent school districts). The announcement also explicitly includes a range of institutions and organizational categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, tribal governments and tribal organizations (including certain non-federally recognized categories as specified), regional organizations, U.S. territories or possessions, faith-based and community-based organizations, eligible federal agencies, and public housing authorities/Indian housing authorities. The activity category is Health, and the CFDA number associated with this program is 93.859 (Biomedical Research and Research Training).
Administrative timing details in the source listing show the opportunity was posted July 31, 2009, created August 12, 2009, with an original closing date of October 9, 2009 and a current closing date of October 28, 2009, and an archive date of November 28, 2009. The full announcement was hosted through the NIH Grants Guide at the provided link (http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-10-005.html), with NIH Office of Extramural Research (OER) webmaster contacts included for access and linking issues.
In short, this FOA was designed to stand up a small number of large, highly capable, high-throughput structural biology centers that collectively anchor the PSIBiology network, deliver very high annual structure output to the PDB, and operate under a cooperative agreement model that emphasizes coordinated network governance and active NIH involvement.
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This opportunity is the "Centers for High Throughput Structure Determination (U54)" funding opportunity announcement (FOA) RFA-GM-10-005. It is an NIH program administered by the National Institute of General Medical Sciences (NIGMS) to establish major production-style structural biology centers that operate at true high-throughput scale.
Which NIH institute administers this FOA?
The FOA is administered through the National Institute of General Medical Sciences (NIGMS), which is part of the National Institutes of Health (NIH).
What is the main goal of the program?
The main goal is to build a set of large, high-capacity structural biology centers that can run end-to-end macromolecular structure determination as an efficient, repeatable, production-style pipeline. These centers are intended to form the backbone of the PSIBiology network, extending capabilities developed in earlier phases of the Protein Structure Initiative (PSI).
What is PSIBiology, and how does this FOA relate to it?
The FOA is designed to create the backbone of the PSIBiology network. The centers funded under this announcement are expected to be coordinated components of that network, rather than standalone centers operating independently.
What does "high-throughput" mean in the context of this FOA?
In this FOA, high-throughput refers to operating structure determination at industrial-strength, production scale, using efficient and repeatable workflows. The description emphasizes a pipeline approach (people, instrumentation, automation, informatics, and standardized processes) rather than occasional, investigator-driven structure projects.
Is there an expected output benchmark for funded centers?
Yes. An illustrative benchmark described in the opportunity is roughly 200 macromolecular structures per year deposited into the Protein Data Bank (PDB). This is presented as an example of the production-scale output NIGMS is seeking.
What is the Protein Data Bank (PDB) role in this program?
The FOA highlights that centers are expected to deposit macromolecular structures into the Protein Data Bank (PDB), with the benchmark of about 200 deposited structures per year used to illustrate the intended scale of output.
What is the award mechanism, and what does it imply?
The mechanism is a U54 cooperative agreement. A cooperative agreement signals substantial NIH programmatic involvement compared with a standard research project grant, including NIH engagement in coordination across the PSIBiology effort.
How is a U54 cooperative agreement different from a typical grant?
Based on the FOA description, the cooperative agreement structure indicates that NIH staff will be actively involved in coordinating interactions across the network, helping align goals, facilitating collaboration, and supporting integrated operation of PSIBiology components. This also implies that milestones, data sharing, coordination, and operational transparency are important expectations.
Are these meant to be isolated center grants or part of a coordinated network?
They are explicitly intended to be networked and coordinated. The FOA emphasizes coordinated science rather than isolated center efforts, with joint planning and shared decision-making across the PSIBiology network.
What governance or coordination responsibilities are expected of awardees?
Awarded principal investigators are expected to serve as members of the PSIBiology Network Steering Committee. This includes active governance and coordination responsibilities such as joint planning, shared decision-making, and regular interactions with other PSIBiology components and NIH staff.
What kinds of capabilities are applicants expected to provide?
The FOA indicates centers are expected to provide capacity for production-scale structural determination, including people, instrumentation, automation, informatics, and standardized processes that support an end-to-end, efficient, repeatable workflow.
How much total funding is available through this announcement?
NIGMS indicated an estimated total of up to $28,000,000 available through this announcement.
How many awards are anticipated?
The FOA anticipates making approximately 3 to 5 awards.
What is the maximum award size listed?
The award ceiling listed in the opportunity is $8,000,000.
Is there a cost sharing or matching requirement?
No cost sharing or matching requirement is noted in the information provided for this FOA.
Who is eligible to apply?
Eligibility is broad and includes many organization types typically eligible for NIH funding. This includes public and private institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and multiple levels of government (state, county, city/township, special district, and independent school districts).
Are minority-serving institutions and tribal organizations included in eligibility?
Yes. The eligibility description explicitly includes organizations and categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, tribally controlled colleges and universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, tribal governments and tribal organizations (including certain non-federally recognized categories as specified), and related eligible entities.
Are faith-based or community-based organizations eligible?
Yes. The eligibility list explicitly includes faith-based and community-based organizations.
Are U.S. territories or possessions mentioned as eligible?
Yes. The eligibility description includes U.S. territories or possessions.
Are federal agencies eligible to apply?
Yes. The eligibility list includes eligible federal agencies.
What is the activity category for this program?
The activity category identified for this opportunity is Health.
What is the CFDA number associated with this program?
The CFDA number provided for this program is 93.859 (Biomedical Research and Research Training).
When was the opportunity posted and created?
The listing indicates the opportunity was posted on July 31, 2009, and created on August 12, 2009.
What were the closing dates for this FOA?
The source listing shows an original closing date of October 9, 2009 and a current closing date of October 28, 2009.
When was the opportunity archived?
The archive date shown in the listing is November 28, 2009.
Where can applicants find the full announcement?
The full announcement was hosted through the NIH Grants Guide at: http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-10-005.html
Who is listed for technical website access or linking issues?
The information provided notes that NIH Office of Extramural Research (OER) webmaster contacts were included for access and linking issues.
What is the big picture expectation for how centers will operate?
The FOA describes an expectation that funded centers will operate as a national-scale resource for high-throughput enabled structural biology, with priorities and operational practices shaped through the PSIBiology network governance rather than set by any single site.
Does the FOA emphasize collaboration and accountability?
Yes. The cooperative agreement model and the networked structure described in the FOA emphasize collaboration, shared governance, coordination, milestone-driven work, data sharing, and operational transparency across the PSIBiology effort.
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