Opportunity Information: Apply for RFA GM 10 006
Apply for RFA GM 10 006
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers for Membrane Protein Structure Determination (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Aug 12, 2009 and posted on Jul 27, 2009.
- Applicants must submit their applications by Oct 28, 2009. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $8,000,000.00 to eligible and selected applicants.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) County governments Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Special district governments Public and State controlled institutions of higher education Small businesses Public housing authorities/Indian housing authorities Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) For profit organizations other than small businesses Independent school districts City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Centers for Membrane Protein Structure Determination (U54) funding opportunity (RFA-GM-10-006) is a National Institutes of Health program run through the National Institute of General Medical Sciences (NIGMS) to create specialized centers focused on determining the structures of membrane proteins. The main idea is to stand up a set of high-capacity, high-throughput centers that can reliably produce membrane protein structures and, in doing so, help drive the expanded goals of the NIGMS PSI:Biology network. In practical terms, these centers are meant to be core, networked hubs for technology-enabled structural biology, with an emphasis on scaling up workflows so that membrane protein structure determination becomes more systematic, efficient, and broadly useful to the biomedical community.
A key feature of the program is that it is organized as a cooperative agreement (U54), not a standard research grant. That distinction matters because NIH staff are expected to be actively involved in coordinating the broader initiative. Awardees are not operating in isolation; principal investigators of funded centers become members of the PSI:Biology Network Steering Committee and are expected to work closely with other funded investigators and NIH program staff. The cooperative structure reflects the reality that a distributed network of centers and related components needs ongoing coordination around priorities, standards, milestones, data sharing, and the overall management of the PSI:Biology effort.
The opportunity sits in the NIH health funding activity area and is associated with CFDA 93.859 (Biomedical Research and Research Training). NIGMS planned an estimated total of about $8,000,000 in funding under this announcement, with anticipated individual awards ranging broadly such that the total program would amount to roughly $8 million to $15 million, and with an expected number of awards in the range of about 4 to 10 centers. There is no cost sharing or matching requirement, which generally means applicants are not required to commit institutional funds as a formal condition of the award (though, as with many center-style applications, strong institutional support can still be an important practical advantage).
Eligibility is broad and includes many types of domestic organizations that commonly apply to NIH opportunities. Eligible applicants include public and private institutions of higher education, public and state-controlled institutions of higher education, nonprofit organizations (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses and other for-profits), and a wide range of government entities such as state governments, county governments, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities. The announcement also explicitly recognizes additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible agencies of the federal government, as well as tribal governments (federally recognized and other than federally recognized) and other Native American tribal organizations.
From a timeline standpoint, the opportunity was posted July 27, 2009, created August 12, 2009, with an original closing date of October 9, 2009, later reflected as October 28, 2009, and an archive date of November 28, 2009. The full announcement was hosted on the NIH grants site, and the notice provided standard NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues. Overall, the program can be understood as NIH’s push at that time to build coordinated, production-oriented membrane protein structure centers that plug into a larger national network, using a cooperative agreement model to ensure tight integration, shared goals, and consistent progress across the initiative.
Frequently Asked Questions (FAQs)
What is the Centers for Membrane Protein Structure Determination (U54) opportunity?
This opportunity (RFA-GM-10-006) is an NIH program run through the National Institute of General Medical Sciences (NIGMS) to create specialized centers focused on determining the structures of membrane proteins. The intent is to establish high-capacity, high-throughput centers that can reliably produce membrane protein structures and support the broader goals of the NIGMS PSI:Biology network.
What is the main purpose of these centers?
The centers are designed to function as production-oriented, technology-enabled hubs for structural biology. A central emphasis is scaling and standardizing workflows so membrane protein structure determination becomes more systematic, efficient, and broadly useful to the biomedical research community.
How does this program connect to PSI:Biology?
The centers are intended to plug into and help drive the expanded goals of the NIGMS PSI:Biology network. In practice, they operate as core, networked components within that initiative rather than as standalone projects.
What funding mechanism is used for this opportunity?
The program uses a cooperative agreement mechanism (U54), not a standard research grant mechanism. This is a key feature of the opportunity.
Why does it matter that this is a U54 cooperative agreement?
Because it is a cooperative agreement, NIH staff are expected to be actively involved in coordinating the broader initiative. The structure reflects the need for ongoing coordination across a distributed network of centers around priorities, standards, milestones, data sharing, and overall management of the PSI:Biology effort.
What coordination responsibilities are expected of awardees?
Awardees are not expected to operate in isolation. Principal investigators of funded centers become members of the PSI:Biology Network Steering Committee and are expected to work closely with other funded investigators and NIH program staff.
What NIH institute runs this opportunity?
The opportunity is run through the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH).
What is the CFDA number associated with this opportunity?
The opportunity is associated with CFDA 93.859 (Biomedical Research and Research Training).
How much funding was NIGMS planning to provide under this announcement?
NIGMS planned an estimated total of about $8,000,000 in funding under the announcement. The description also indicates anticipated individual awards could range broadly such that the overall program would amount to roughly $8 million to $15 million.
How many awards were expected to be made?
The expected number of awards was in the range of about 4 to 10 centers.
Is cost sharing or matching required?
No. The announcement indicates there is no cost sharing or matching requirement, meaning applicants are not required to commit institutional funds as a formal condition of the award.
Even without a cost-share requirement, does institutional support matter?
The notice notes that, as with many center-style applications, strong institutional support can still be an important practical advantage, even when it is not a formal cost-sharing requirement.
What types of organizations are eligible to apply?
Eligibility is broad and includes many types of domestic organizations that commonly apply to NIH opportunities, including higher education institutions, nonprofit organizations, for-profit organizations, and many categories of government entities.
Are colleges and universities eligible?
Yes. The eligible applicants list includes public and private institutions of higher education and public and state-controlled institutions of higher education.
Are nonprofit organizations eligible?
Yes. Eligibility includes nonprofit organizations, including both 501(c)(3) and non-501(c)(3) entities.
Are for-profit organizations eligible?
Yes. Eligibility includes for-profit organizations, including small businesses and other for-profits.
Are state and local government entities eligible?
Yes. The eligible categories include state governments, county governments, city or township governments, independent school districts, special district governments, and public housing authorities/Indian housing authorities.
Are U.S. territories or possessions eligible?
Yes. The eligibility description explicitly includes U.S. territories or possessions.
Are tribal governments and Native American organizations eligible?
Yes. Eligibility includes tribal governments (federally recognized and other than federally recognized) and other Native American tribal organizations.
Are minority-serving institutions called out as eligible?
Yes. The announcement explicitly recognizes categories including Alaska Native and Native Hawaiian Serving Institutions, Hispanic Serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly listed among eligible categories.
Are regional organizations eligible?
Yes. Regional organizations are explicitly listed among eligible categories.
Are federal government agencies eligible?
Yes. The eligibility description includes eligible agencies of the federal government.
When was the opportunity posted and created?
The opportunity was posted on July 27, 2009, and created on August 12, 2009.
What were the closing dates for the opportunity?
The original closing date is described as October 9, 2009, and it is later reflected as October 28, 2009.
When was the opportunity archived?
The archive date is listed as November 28, 2009.
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants site.
Who was listed as a contact for access or linking issues?
The notice provided standard NIH Office of Extramural Research (OER) webmaster contacts for access or linking issues.
In plain terms, what was NIH trying to accomplish with this initiative?
Overall, NIH was pushing to build coordinated, production-oriented membrane protein structure centers that connect into a larger national network. The cooperative agreement model was used to support tight integration, shared goals, and consistent progress across the initiative.
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