Opportunity Information: Apply for PA 11 178
Apply for PA 11 178
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Circadian Rhythms and Alcohol induced Tissue Injury (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Mar 24, 2011 and posted on Mar 24, 2011.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts County governments Others (see text field entitled Additional Information on Eligibility for clarification) State governments City or township governments Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Private institutions of higher education Small businesses Public housing authorities/Indian housing authorities For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Opportunity Summary:
The Circadian Rhythms and Alcohol induced Tissue Injury (R01) funding opportunity (PA 11-178) was a National Institutes of Health (NIH) research grant announcement designed to support mechanistic, hypothesis-driven studies on how circadian biology contributes to alcohol-related organ and tissue damage. The central idea behind the FOA is that the body runs on an internal timekeeping system, and alcohol can both disrupt that system and have effects that vary depending on the time of day. Because circadian regulation influences core processes like metabolism, hormone signaling, inflammation, and cellular repair, NIH sought projects that could explain, at a molecular level, how interactions between circadian rhythms and alcohol exposure translate into tissue injury.
A major emphasis of the announcement is the circadian system as a coordinated network rather than a single clock. It highlights the interplay between the central nervous system clock (often associated with the master pacemaker in the brain) and peripheral clocks located in organs and tissues throughout the body. The FOA points out that central and peripheral oscillators may each contribute to alcohol-induced damage on their own, or they may work together in ways that amplify injury. Applications were therefore encouraged to look beyond simple associations and instead dissect specific pathways and feedback loops linking circadian timing to alcohol-related pathology.
The scientific objective was to deepen understanding of the molecular mechanisms of alcohol-induced tissue damage that specifically involve circadian rhythms, with particular attention to connections with metabolism and metabolic disorders. In practical terms, this means the FOA was aimed at studies exploring how alcohol interacts with circadian control of metabolic programs such as lipid handling, glucose regulation, mitochondrial function, oxidative stress responses, inflammatory signaling, and energy balance. Since metabolic disruption is a common thread in many alcohol-related diseases, NIH framed circadian-metabolic coupling as a promising lens for explaining why certain organs become vulnerable and why injury severity can differ depending on timing, dosing patterns, or underlying metabolic status.
This opportunity used the R01 mechanism, meaning it supported substantial, multi-year research projects typically suited for well-developed aims and rigorous experimental plans. It fell under the Health funding activity category, with CFDA number 93.273 (Alcohol Research Programs). There was no cost sharing or matching requirement, which is typical for many NIH research grants.
Eligibility was broad and included a wide range of potential applicants across academia, government, and the nonprofit and private sectors. Eligible applicants listed in the source include public and private institutions of higher education, public and state-controlled universities, nonprofits with or without 501(c)(3) status (excluding institutions of higher education where relevant), small businesses, for-profit organizations other than small businesses, independent school districts, and multiple levels of government (county, city/township, state, special district, and certain housing authorities). The FOA also explicitly included tribal governments and tribal organizations, including federally recognized tribal governments as well as other tribal entities, along with minority-serving and special-designation institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities. Faith-based and community-based organizations were also included as eligible. Importantly, the announcement allowed non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and foreign components of U.S. organizations, reflecting NIH openness to strong science regardless of geography when allowable under policy.
Administratively, the FOA was posted and created on March 24, 2011, with an original and current closing date listed as May 7, 2013, and it was archived on June 7, 2013. The announcement is associated with NIH, and the provided public link points to the NIH Grants Guide page for PA 11-178. For access issues or technical problems with the online announcement, the contact listed is the NIH Office of Extramural Research (OER) webmaster (FBOWebmaster@OD.NIH.GOV).
In summary, this FOA targeted research that could explain how internal biological timing systems shape, and are shaped by, alcohol exposure in ways that lead to organ damage. By prioritizing mechanistic studies of central and peripheral circadian oscillators and their ties to metabolism and metabolic disease, the program aimed to generate insights that could ultimately inform better prevention strategies, timing-aware interventions, or novel therapeutic targets for alcohol-induced tissue injury.
Frequently Asked Questions (FAQs)
What is the title and identifier of this funding opportunity?
The opportunity is titled "Circadian Rhythms and Alcohol induced Tissue Injury (R01)" and is identified as PA 11-178.
Which agency offered this grant opportunity?
This funding opportunity was offered through the National Institutes of Health (NIH).
What kind of grant mechanism is used?
The announcement uses the R01 mechanism, which is typically intended to support substantial, multi-year research projects with well-developed specific aims and rigorous experimental plans.
What overall research topic does the FOA focus on?
The FOA focuses on mechanistic, hypothesis-driven research on how circadian biology contributes to alcohol-related organ and tissue damage, including how alcohol can disrupt internal timing systems and how alcohol effects may vary by time of day.
What is the central scientific idea behind the FOA?
The central idea is that the body operates on an internal timekeeping system (circadian rhythms), and alcohol both affects that system and may cause different biological outcomes depending on timing. Because circadian regulation influences processes such as metabolism, hormone signaling, inflammation, and cellular repair, the FOA sought molecular-level explanations for how circadian timing and alcohol exposure interact to produce tissue injury.
Does the FOA prioritize mechanistic studies or observational associations?
The FOA emphasizes mechanistic work. It encourages applicants to go beyond simple associations and to dissect specific pathways and feedback loops that connect circadian timing to alcohol-related pathology.
How does the FOA describe the circadian system?
It frames the circadian system as a coordinated network rather than a single clock, highlighting interplay between a central nervous system clock (often linked to the master pacemaker in the brain) and peripheral clocks in organs and tissues throughout the body.
Are projects expected to look at central clocks, peripheral clocks, or both?
Applications were encouraged to consider that central and peripheral oscillators may each contribute to alcohol-induced damage independently, or they may interact in ways that amplify injury. This makes both central and peripheral circadian components relevant within the scope described.
What specific scientific objective is stated?
The stated objective is to deepen understanding of the molecular mechanisms of alcohol-induced tissue damage that specifically involve circadian rhythms, with particular attention to connections with metabolism and metabolic disorders.
Why is metabolism highlighted in this FOA?
The FOA identifies circadian-metabolic coupling as a promising lens because circadian regulation influences metabolic programs, and metabolic disruption is a common thread in many alcohol-related diseases. The FOA aims to explain organ vulnerability and differences in injury severity based on timing, dosing patterns, or metabolic status.
What kinds of biological processes are mentioned as being within scope?
The FOA references metabolic and related programs such as lipid handling, glucose regulation, mitochondrial function, oxidative stress responses, inflammatory signaling, and energy balance, in the context of how alcohol interacts with circadian control to contribute to tissue injury.
What is the funding activity category and CFDA number?
The funding activity category is Health. The CFDA number listed is 93.273 (Alcohol Research Programs).
Is cost sharing or matching required?
No. The announcement specifies that there is no cost sharing or matching requirement.
Who is eligible to apply?
Eligibility is broad and includes a wide range of applicants across academia, government, nonprofit, and private sectors, as described in the announcement.
Are colleges and universities eligible?
Yes. Eligible applicants include public and private institutions of higher education and public and state-controlled institutions of higher education.
Are nonprofit organizations eligible?
Yes. The eligible applicant types include nonprofits with or without 501(c)(3) status (excluding institutions of higher education where relevant).
Are for-profit organizations eligible?
Yes. The eligible applicant list includes small businesses and for-profit organizations other than small businesses.
Are K-12 or local education agencies eligible?
Independent school districts are listed among eligible applicants.
Which government entities are eligible?
The eligible list includes multiple levels of government, including county, city or township, state, special district governments, and certain housing authorities.
Are tribal governments and tribal organizations eligible?
Yes. The FOA explicitly includes federally recognized tribal governments and other tribal entities, as well as tribal organizations.
Are minority-serving institutions specifically included?
Yes. The eligibility description includes institutions such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and Tribally Controlled Colleges and Universities.
Are faith-based or community-based organizations eligible?
Yes. The FOA states that faith-based and community-based organizations are included as eligible applicants.
Are non-U.S. (foreign) organizations allowed to apply?
Yes. The FOA allows non-U.S. entities (foreign organizations), regional organizations, U.S. territories or possessions, and foreign components of U.S. organizations, reflecting openness to strong science regardless of geography when allowable under NIH policy.
When was this FOA posted, and what are the key dates provided?
The FOA was posted and created on March 24, 2011. The original and current closing date listed is May 7, 2013, and the opportunity was archived on June 7, 2013.
Where can applicants find the official announcement?
The information references the NIH Grants Guide page for PA 11-178 as the public link destination for the announcement.
Who should be contacted for access issues or technical problems with the online announcement?
The contact listed for access issues or technical problems is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What types of research outcomes was NIH hoping to enable through this FOA?
Based on the description, NIH aimed to generate molecular and mechanistic insights into how biological timing systems shape, and are shaped by, alcohol exposure in ways that cause organ damage, with the longer-term goal of informing prevention strategies, timing-aware interventions, or new therapeutic targets for alcohol-induced tissue injury.
Browse more opportunities from the same category: Health
Next opportunity: Circadian Rhythms and Alcohol induced Tissue Injury (R21)
Previous opportunity: Translational Research for the Development of Novel Interventions for Mental Disorders (R21/R33)
USGrants.org Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PA 11 178
[Watch] how do funding administrators access proposals?
Applicants also applied for:
Applicants who have applied for this opportunity (PA 11 178) also looked into and applied for these:
| Funding Opportunity |
|---|
| Circadian Rhythms and Alcohol induced Tissue Injury (R21) Apply for PA 11 179 Funding Number: PA 11 179 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Health Careers Opportunity Program Apply for HRSA 11 065 Funding Number: HRSA 11 065 Agency: Health Resources and Services Administration Category: Health Funding Amount: Case Dependent |
| Surveillance and Response to Seasonal and Pandemic Influenza by Regional Offices of the World Health Organization Apply for CDC RFA IP11 1104 Funding Number: CDC RFA IP11 1104 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $1,500,000 |
| Evaluation of Core Violence and Injury Prevention Program (Core VIPP) Apply for CDC RFA CE11 1106 Funding Number: CDC RFA CE11 1106 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $300,000 |
| Integrated Health Social Marketing Apply for RFA674 11 27 Funding Number: RFA674 11 27 Agency: South Africa USAID Pretoria Category: Health Funding Amount: $20,000,000 |
| Systems Approach to Immunity and Inflammation (U19) Apply for RFA AI 11 017 Funding Number: RFA AI 11 017 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Multidisciplinary Clinical Research Centers (P60) Apply for RFA AR 12 001 Funding Number: RFA AR 12 001 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Enhanced Comprehensive HIV Prevention Planning and Implementation for Metropolitan Statistical Areas Most Affected by HIV/AIDS Phase II Apply for CDC RFA PS11 1117 Funding Number: CDC RFA PS11 1117 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $600,000 |
| Integrated Economic, Dynamic Disease, Risk and Decision Analytic Modeling of Global and Domestic Policy Issues for Polio Apply for CDC RFA IP11 1102 Funding Number: CDC RFA IP11 1102 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Translation of Pluripotent Stem Cell Therapies for Blood Diseases (R01) Apply for PA 11 186 Funding Number: PA 11 186 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| A National Coalition to Enhance STD/HIV Prevention through Promotion of a Holistic Approach to Health and Wellness Apply for CDC RFA PS11 1112 Funding Number: CDC RFA PS11 1112 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $135,000 |
| Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery (UM1) Apply for RFA AI 11 002 Funding Number: RFA AI 11 002 Agency: National Institutes of Health Category: Health Funding Amount: $19,000,000 |
| Initiatives to Educate State Officials and Policy Makers about Priority Public Health Issues Related to the Prevention and Control of Sexually Transmitted Diseases (STDs) and Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome ( Apply for CDC RFA PS11 1118 Funding Number: CDC RFA PS11 1118 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: $250,000 |
| Eliminating Mother to Child HIV Transmission in the United States through Continuous Quality Improvement The FIMR HIV Prevention Methodology Apply for CDC RFA PS11 1116 Funding Number: CDC RFA PS11 1116 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| PPHF 2012 Immunization Capacity Building Assistance to Strengthen Public Health Immunization Infrastructure and Performance financed in part by 2012 Prevention and Public Health Funds Apply for CDC RFA IP11 1107PPHF11 Funding Number: CDC RFA IP11 1107PPHF11 Agency: Centers for Disease Control and Prevention Category: Health Funding Amount: Case Dependent |
| Next Generation PrEP II (R01) Apply for RFA AI 11 023 Funding Number: RFA AI 11 023 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Cooperative Agreements for Screening, Brief Intervention and Referral to Treatment Apply for TI 11 005 Funding Number: TI 11 005 Agency: Substance Abuse Mental Health Services Adminis. Category: Health Funding Amount: $1,666,000 |
| Limited Competition for the Continuation of Rare Diseases Clinical Research Consortia in the Rare Diseases Clinical Research Network (U54) Apply for PAR 11 187 Funding Number: PAR 11 187 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Optimizing Fidelity of Empirically Supported Behavioral Treatments for Mental Disorders (R21/R33) Apply for RFA MH 12 050 Funding Number: RFA MH 12 050 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Strengthening Angolan Systems for Health (SASH) Apply for RFA674 11 32 Funding Number: RFA674 11 32 Agency: South Africa USAID Pretoria Category: Health Funding Amount: $33,000,000 |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Subscribe to Leads
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PA 11 178", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.