Opportunity Information: Apply for PA 11 179
Apply for PA 11 179
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Circadian Rhythms and Alcohol induced Tissue Injury (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273 Alcohol Research Programs.
- This funding opportunity was created on Mar 24, 2011 and posted on Mar 24, 2011.
- Applicants must submit their applications by May 7, 2013. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $200,000.00 in funding.
- Eligible applicants include: City or township governments Public housing authorities/Indian housing authorities State governments Special district governments Independent school districts Others (see text field entitled Additional Information on Eligibility for clarification) County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public and State controlled institutions of higher education Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Private institutions of higher education Small businesses For profit organizations other than small businesses.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Foreign (non U.S.) components of U.S. Organizations are allowed.
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Opportunity Summary:
The NIH funding opportunity titled "Circadian Rhythms and Alcohol induced Tissue Injury (R21)" (Funding Opportunity Number PA-11-179) supported exploratory, mechanistic research aimed at explaining how circadian biology contributes to alcohol-related organ damage. The central idea behind the announcement is that the circadian system is not just a simple "sleep clock," but a coordinated feedback network that links the central nervous system with peripheral clocks in organs throughout the body. Because alcohol can disrupt circadian rhythms and, at the same time, the body’s response to alcohol can vary depending on circadian timing, the FOA emphasized that understanding these interactions could reveal why and how alcohol exposure leads to tissue injury in specific organs or under specific metabolic conditions.
A major focus of the FOA was the role of central and peripheral oscillators in driving vulnerability or resilience to alcohol-induced injury. Applicants were encouraged to study how alcohol affects circadian regulation at the molecular and cellular level, and how circadian rhythms, in turn, modulate alcohol’s effects on tissues. The announcement highlighted that central and peripheral clocks may act independently or in combination, meaning that tissue injury could be influenced by brain-driven circadian signaling, organ-autonomous clock activity, or the interaction between both. The objective was to clarify molecular mechanisms linking these clock systems to downstream pathways of injury, with particular attention to how circadian regulation intersects with metabolism, metabolic dysfunction, and metabolic disorders.
Mechanistically, the FOA pointed researchers toward questions at the interface of circadian timing and metabolic control, reflecting the reality that many core circadian genes and pathways regulate energy balance, nutrient handling, and stress responses. Alcohol-related tissue injury often involves metabolic disruption (for example, altered lipid metabolism, oxidative stress, mitochondrial dysfunction, inflammation, and impaired repair processes), and circadian systems influence many of those same pathways. By prioritizing circadian connections with metabolism, the announcement essentially sought studies that could explain time-of-day differences in alcohol toxicity, identify clock-regulated metabolic nodes that worsen injury, or uncover how alcohol-induced clock disruption contributes to longer-term metabolic disease processes that amplify organ damage.
In terms of administrative features, this was a discretionary grant opportunity using the NIH R21 mechanism, which is commonly used to support early-stage, high-risk/high-reward projects that generate mechanistic insight or proof-of-concept data. The award ceiling listed was $200,000, and there was no cost sharing or matching requirement. The opportunity fell under the health funding activity category and was associated with CFDA number 93.273 (Alcohol Research Programs). The FOA was posted and created on March 24, 2011, with an original and final closing date of May 7, 2013, and an archive date of June 7, 2013, meaning it is no longer open for applications.
Eligibility was broad and included many types of domestic applicants such as state, county, city/township, and special district governments; public housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those specific categories); small businesses; and for-profit organizations other than small businesses. The FOA also explicitly allowed a wide range of additional eligible applicants, including Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), tribal governments and tribal organizations (including categories beyond federally recognized tribes as specified), faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and non-U.S. entities (foreign organizations). It also permitted foreign (non-U.S.) components of U.S. organizations, signaling openness to international collaboration or research capacity where scientifically justified.
The sponsoring agency was the National Institutes of Health, and the full announcement was hosted on the NIH grants guide site (link provided in the source). For technical access issues, the contact point listed was the NIH Office of Extramural Research (OER) Webmaster (FBOWebmaster@OD.NIH.GOV), indicating that inquiries were primarily about accessing the announcement rather than scientific program questions in the provided text. Overall, the opportunity was designed to push the field toward a clearer, molecular-level explanation of how circadian timing systems shape alcohol-related tissue damage, especially through pathways tied to metabolism and metabolic disease.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this NIH grant?
The opportunity is titled "Circadian Rhythms and Alcohol induced Tissue Injury (R21)" and the Funding Opportunity Number is PA-11-179.
What type of research was this funding opportunity trying to support?
This FOA supported exploratory, mechanistic research aimed at explaining how circadian biology contributes to alcohol-related organ (tissue) damage. The emphasis was on molecular and cellular mechanisms, including how alcohol disrupts circadian regulation and how circadian timing changes the body’s response to alcohol exposure.
What is the main scientific idea behind the announcement?
The FOA was built around the idea that the circadian system is more than a simple "sleep clock." It is described as a coordinated feedback network that links the central nervous system with peripheral clocks in organs throughout the body. Because alcohol can disrupt circadian rhythms, and because alcohol effects can vary depending on circadian timing, the FOA encouraged research to clarify how these interactions drive tissue injury.
What does the FOA mean by central and peripheral clocks?
In the context provided, "central" refers to circadian signaling driven by the central nervous system, while "peripheral" refers to organ-based, tissue-autonomous clocks found in organs throughout the body. The FOA highlighted that these oscillators may act independently or together, potentially influencing vulnerability or resilience to alcohol-induced injury.
What kinds of mechanisms or pathways were emphasized?
The FOA pointed researchers toward mechanistic questions where circadian timing intersects with metabolic control and metabolic dysfunction. It emphasized that many circadian genes and pathways regulate energy balance, nutrient handling, and stress responses, and that alcohol-related tissue injury often involves metabolic disruption and related biological stress pathways.
How did the FOA connect circadian rhythms to metabolism and metabolic disease?
The announcement prioritized circadian connections with metabolism because both circadian systems and alcohol-related tissue injury influence overlapping processes. It sought studies that could explain time-of-day differences in alcohol toxicity, identify clock-regulated metabolic nodes that worsen injury, or clarify how alcohol-induced circadian disruption contributes to longer-term metabolic disease processes that amplify organ damage.
What examples of metabolic disruption related to alcohol injury were mentioned?
The description gave examples including altered lipid metabolism, oxidative stress, mitochondrial dysfunction, inflammation, and impaired repair processes. These were presented as common components of alcohol-related tissue injury that also intersect with circadian regulation.
Did the FOA specify whether tissue injury is driven by the brain, by organs, or both?
It explicitly raised the possibility that tissue injury could be influenced by brain-driven circadian signaling, organ-autonomous (peripheral) clock activity, or the interaction between central and peripheral clock systems. The goal was to clarify molecular mechanisms linking these clock systems to downstream pathways of injury.
What grant mechanism was used?
This was an NIH R21 mechanism opportunity. The R21 is commonly used for early-stage, high-risk/high-reward projects designed to generate mechanistic insight or proof-of-concept data.
What was the maximum award amount listed?
The award ceiling listed was $200,000.
Was cost sharing or matching required?
No. The FOA stated there was no cost sharing or matching requirement.
What funding activity category was this opportunity under?
The opportunity fell under the health funding activity category.
What CFDA number was associated with this opportunity?
The FOA was associated with CFDA 93.273 (Alcohol Research Programs).
When was the FOA posted and when did it close?
It was posted and created on March 24, 2011. The original and final closing date was May 7, 2013, and the archive date was June 7, 2013.
Is this funding opportunity still open for applications?
No. Based on the final closing date (May 7, 2013) and the archive date (June 7, 2013), the opportunity is no longer open for applications.
Who sponsored this funding opportunity?
The sponsoring agency was the National Institutes of Health (NIH).
Where was the full announcement hosted?
The full announcement was hosted on the NIH grants guide site (a link was noted as being provided in the source information).
Who was eligible to apply?
Eligibility was broad. It included many types of domestic applicants such as state, county, city/township, and special district governments; public housing authorities; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those specific categories); small businesses; and for-profit organizations other than small businesses.
Were minority-serving institutions and tribal entities included as eligible applicants?
Yes. The FOA explicitly allowed applicants such as Alaska Native and Native Hawaiian Serving Institutions, Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), tribal governments, and tribal organizations (including categories beyond federally recognized tribes as specified in the FOA text summary provided).
Could faith-based or community-based organizations apply?
Yes. The eligibility list explicitly included faith-based or community-based organizations.
Were U.S. territories or possessions eligible?
Yes. The FOA included U.S. territories or possessions among eligible applicants.
Were foreign organizations eligible to apply?
Yes. The FOA included non-U.S. entities (foreign organizations) as eligible applicants, and it also permitted foreign (non-U.S.) components of U.S. organizations, indicating that international collaboration or research capacity could be included when scientifically justified.
What kinds of applicant organizations were explicitly included on the for-profit side?
The FOA included small businesses and for-profit organizations other than small businesses as eligible applicants.
What was the stated objective of the FOA in plain terms?
The objective was to push the field toward a clearer molecular-level explanation of how circadian timing systems shape alcohol-related tissue damage, with special attention to how circadian regulation intersects with metabolism, metabolic dysfunction, and metabolic disorders.
Did the provided information include a scientific program contact?
No scientific program contact was included in the text provided. The only listed contact in the provided information was for technical access issues related to the announcement.
Who was listed for technical access issues?
The contact point listed for technical access issues was the NIH Office of Extramural Research (OER) Webmaster at FBOWebmaster@OD.NIH.GOV.
What kinds of questions were applicants encouraged to pursue?
Applicants were encouraged to study how alcohol affects circadian regulation at the molecular and cellular level, how circadian rhythms modulate alcohol’s effects on tissues, and how central and peripheral oscillators contribute to vulnerability or resilience. The FOA also emphasized questions about time-of-day differences in alcohol toxicity and how alcohol-driven circadian disruption may contribute to metabolic disease processes that worsen organ damage.
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