Clinical Coordinating Center for the Severe Asthma Research Program (SARP) (U10) | Apply Online

Opportunity Summary:

The funding opportunity RFA-HL-11-030 is a National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) request for applications to serve as the Clinical Coordinating Center (CCC) for the Severe Asthma Research Program (SARP). It uses a cooperative agreement mechanism (U10), meaning the awardee is expected to work closely with NHLBI and the rest of the SARP network in an active, collaborative partnership rather than operating as a fully independent, investigator-directed project. The overall program is designed around the idea that severe asthma is not a single uniform condition, but a complex and changing set of subphenotypes that vary between people and can shift over time. Because the biological drivers and the stability of these subphenotypes are not well understood, progress in targeted treatment and long-term management has been limited. This phase of SARP is intended to help reset how the field defines and studies severe asthma by focusing on molecular and cellular characterization over time in both children and adults.

A central scientific theme of the program is longitudinal, mechanistic research. Instead of relying primarily on cross-sectional snapshots, SARP is structured to track participants over time to understand how asthma phenotypes develop, persist, and fluctuate, and how those patterns relate to underlying biology. Investigators are expected to use mechanistic approaches and "evoked phenotype" strategies (ways of probing the system to reveal biological response patterns) to characterize developmental molecular, cellular, and physiologic phenotypes across the spectrum from mild to severe asthma. The practical goal is to enable better prediction of phenotype stability or change and to improve prediction of pharmacologic response, while also surfacing novel disease-modifying therapeutic targets. Importantly, the announcement makes clear what it is not trying to fund: cross-sectional studies as a primary design and therapeutic clinical trials are not the intent of this FOA.

The CCC role exists because the program is explicitly multi-center and heavily dependent on standardization and shared operations. SARP will include up to six Clinical Centers plus the CCC and a Steering Committee. Across those sites, SARP investigators will jointly define key research questions and implement a shared longitudinal protocol used at all participating centers, with common data elements collected for every SARP participant. The network will also support additional research questions that are distinct from the shared longitudinal protocol, which could be pursued using the shared protocol framework and/or subsets of participants from one or more centers. In that context, the CCC is expected to be the operational backbone that helps the network function as a unified study rather than a collection of parallel site projects, supporting the consistent implementation of the shared protocol and the harmonized capture of information across all centers.

Because the program aims to define asthma subphenotypes at a molecular and cellular level and link those findings to physiology and clinical features over time, it inherently requires broad scientific coordination. The FOA highlights the need for multidisciplinary collaboration and partnerships among asthma clinician-scientists and experts in immunology, pulmonary physiology, molecular genetics, molecular phenotyping, imaging, and bioinformatics. That emphasis signals that the CCC is likely to coordinate complex workflows and interfaces across domains, including standardized collection of clinical and physiologic measures, biospecimen and molecular data integration, and the kinds of data management practices needed to support longitudinal, multi-modal phenotyping.

From an administrative standpoint, the opportunity falls under the Health activity category and is tied to CFDA 93.838 (Lung Diseases Research). There is no cost-sharing or matching requirement. The posted date was May 26, 2010, with an original and current closing date of October 15, 2010, and an archive date of November 15, 2010. NHLBI estimated total funding for the broader effort at $31,500,000. Eligibility is broad and includes public and private institutions of higher education, nonprofit organizations (with and without 501(c)(3) status), for-profit organizations (including small businesses and other for-profits), state, county, city/township governments, special district governments, independent school districts, tribal governments and tribal organizations, and a range of mission-focused institution types such as HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian-serving institutions, U.S. territories or possessions, and faith-based or community-based organizations. The CCC solicitation runs in parallel with a separate FOA for the Clinical Centers (referenced as RFA-HL-11-018), underscoring that the CCC application is specifically for the coordinating function within an integrated network rather than for operating as one of the enrolling clinical sites.

In plain terms, this grant opportunity is about funding the central coordinating hub for a national, multi-center research program focused on understanding severe asthma as a set of evolving biological subtypes. The CCC is meant to make the shared longitudinal protocol feasible at scale, ensure consistency across sites, and support the collaborative structure needed to connect clinical trajectories with deep molecular and cellular phenotyping over time, ultimately helping the field move toward more stable phenotype definitions, better response prediction, and identification of disease-modifying targets.

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Previous opportunity: Clinical Centers for the Severe Asthma Research Program (SARP) (U10)

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