Clinical Studies of Bisphoshonate Therapy and Osteonecrosis of the Jaws (R21) | Apply Online

Opportunity Summary:

The NIH funding opportunity PAR 06-556, titled "Clinical Studies of Bisphosphonate Therapy and Osteonecrosis of the Jaws (R21)," supports exploratory and early-stage clinical research focused on understanding, preventing, diagnosing, and managing osteonecrosis of the jaw associated with bisphosphonate therapy. Bisphosphonates are commonly used medications in conditions like osteoporosis and cancers with bone involvement, and this announcement targets clinical studies that can clarify how these drugs relate to jaw osteonecrosis and what can be done to reduce patient risk and improve outcomes. The overall emphasis is on developing new clinical insights and generating preliminary data that can lead to larger, more definitive studies later on.

This announcement uses the NIH Exploratory/Developmental Grant (R21) mechanism, which is typically intended for innovative, higher-risk projects that are still at an early stage and need support to test feasibility, refine methods, or establish proof of concept. NIH notes that this R21 opportunity is intended to run in parallel with another opportunity of the same scientific scope that would be issued under the R01 mechanism in the future, meaning investigators may be able to pursue a smaller, developmental project under the R21 and later expand into a full-scale R01 if the early findings justify it. The FOA makes clear that funding decisions depend on the availability of funds and on receiving enough strong, competitive applications.

The award structure is flexible because the NIH anticipates that proposed studies will vary widely in design, complexity, and cost. Even so, the listed award ceiling is $200,000, reflecting the R21's role in supporting smaller-scale clinical research rather than large multi-site trials. NIH also indicates that the size and duration of awards may vary depending on the specific project, and that the total amount ultimately awarded will reflect application quality, project duration, and proposed costs. There is no cost sharing or matching requirement, which lowers barriers for applicants who may not have additional funding to contribute.

From an eligibility standpoint, the announcement is broad and includes many types of domestic organizations, such as state and local governments, public and private institutions of higher education, nonprofits (including both 501(c)(3) and non-501(c)(3) organizations), small businesses, other for-profit organizations (other than small businesses), independent school districts, public housing authorities, and federally recognized and other tribal entities. A notable point is that foreign institutions are also eligible to apply, which can be important for international clinical cohorts or collaborations. Applicants are allowed to submit more than one application as long as each submission is scientifically distinct, enabling a research group to propose separate clinical angles or populations without forcing everything into a single project.

Administratively, this is a discretionary grant program in the health area, associated with CFDA 93.121 (Oral Diseases and Disorders Research), and is managed under the National Institutes of Health. The opportunity was posted on September 21, 2006, with multiple receipt dates rather than a single deadline, and it ultimately archived in early 2010 (with a listed current closing date of January 7, 2010, and an archive date of February 7, 2010). In practical terms, that means the specific FOA is no longer active today, but it remains a useful reference point for the kind of clinical questions NIH has solicited around bisphosphonate-related jaw osteonecrosis and for understanding how NIH structures exploratory clinical research support in this area.

For applicants or readers needing official details, NIH provided an additional information link to the full announcement on the NIH grants site and included contact information through the NIH Office of Extramural Research (OER) webmaster for access or technical issues related to the posting.

Browse more opportunities from the same agency: National Institutes of Health

Browse more opportunities from the same category: Health

Next opportunity: Community Based Participatory Research at NIMH (R21)

Previous opportunity: NIDDK Education Program Grants (R25)

USGrants.org Applicant Portal:

Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.

Apply for PAR 06 556

 

[Watch] how do funding administrators access proposals?

Applicants also applied for:

Applicants who have applied for this opportunity (PAR 06 556) also looked into and applied for these:

 

Grant application guides and resources

It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!

Apply for Grants

 

 

Premium leads for funding administrators, grant writers, and loan issuers

Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.

If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.

Subscribe to Leads

 

Request more information:

Would you like to learn more about this funding opportunity, similar opportunities to "PAR 06 556", eligibility, application service, and/or application tips? Submit an inquiry below:

Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.