Opportunity Information: Apply for PA 07 185
Apply for PA 07 185
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical Studies of Bisphosphonate Therapy and Osteonecrosis of the Jaws (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121 Oral Diseases and Disorders Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Dec 18, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education City or township governments Native American tribal governments (Federally recognized) Native American tribal organizations (other than Federally recognized tribal governments) Small businesses County governments Private institutions of higher education For profit organizations other than small businesses Special district governments Independent school districts.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health (NIH), released a funding opportunity titled "Clinical Studies of Bisphosphonate Therapy and Osteonecrosis of the Jaws (R01)" under Funding Opportunity Number PA 07-185. The core goal of this announcement is to support clinical research that clarifies whether, how, and under what conditions bisphosphonate therapy is associated with osteonecrosis of the jaws (ONJ), a serious condition involving exposed or non-healing jawbone that has been reported in some patients receiving these medications. Bisphosphonates are widely used in medicine, particularly to treat osteoporosis and to reduce skeletal complications in cancers that affect bone, so the public health relevance is tied to balancing strong therapeutic benefits with a clearer understanding of rare but severe adverse outcomes in oral and craniofacial tissues.
This opportunity uses the NIH Research Project Grant (R01) mechanism, which is typically intended for more mature, hypothesis-driven projects with a well-developed research plan, appropriate preliminary evidence, and the capacity to execute multi-year studies. The announcement also notes that it runs in parallel with a related FOA (PAR 06-556) that solicits applications under the R21 mechanism. In practice, that means NIH was supporting the same general scientific topic through two complementary pathways: R01 projects aimed at more definitive clinical investigations, and R21 projects aimed at earlier-stage, exploratory, or higher-risk studies that could generate key data needed for later, larger trials.
Rather than setting a fixed budget cap or a set number of awards, NIH indicates that award size and duration will vary depending on the scope of each proposed study. The total funding and the number of funded projects are contingent on several factors typical for NIH competitions: the mix of applications received under the relevant mechanisms, the scientific and technical merit and overall quality of those applications, the proposed project periods, and the requested costs. This structure is common when the agency expects a range of study designs, from smaller observational clinical studies to larger longitudinal cohorts or multi-site efforts, each carrying different cost profiles.
From an administrative standpoint, this is a discretionary grant in the health research category and is listed under CFDA 93.121 (Oral Diseases and Disorders Research). There is no cost sharing or matching requirement, which reduces barriers for applicants who might not have institutional resources to commit matching funds. The FOA was originally posted on December 18, 2006, with multiple receipt dates (rather than a single deadline), meaning applications could be submitted on several standard NIH due dates during the active period. The opportunity ultimately archived on December 6, 2009, indicating it is no longer open for new submissions, but it remains useful as a reference point for how NIH framed research needs around bisphosphonates and ONJ during that period.
Eligibility is broad and includes many types of organizations: public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations (including small businesses), state and local governments, U.S. territories and subdivisions such as counties and special district governments, independent school districts, public housing authorities/Indian housing authorities, and Native American tribal governments and tribal organizations. The announcement also explicitly states that foreign institutions are eligible to apply, and that eligible federal agencies may apply as well. Faith-based and community-based organizations are included as eligible applicants, reflecting NIH policy that eligibility is primarily tied to organizational capacity and compliance rather than organizational affiliation.
Applicants interested in the full details, including scientific scope, recommended research topics, application instructions, and review considerations, were directed to the complete announcement on the NIH grants site (PA 07-185). For technical difficulties accessing or linking to the announcement, NIH provided support through the Office of Extramural Research (OER) webmaster contact.
Frequently Asked Questions (FAQs)
What is the title and funding opportunity number for this grant?
The opportunity is titled "Clinical Studies of Bisphosphonate Therapy and Osteonecrosis of the Jaws (R01)" and it was published under Funding Opportunity Number PA 07-185.
Which NIH institute issued this funding opportunity?
The funding opportunity was issued by the National Institute of Dental and Craniofacial Research (NIDCR), which is part of the National Institutes of Health (NIH).
What is the main goal of this announcement?
The core goal is to support clinical research that clarifies whether, how, and under what conditions bisphosphonate therapy is associated with osteonecrosis of the jaws (ONJ).
What condition is being studied in relation to bisphosphonate therapy?
The announcement focuses on osteonecrosis of the jaws (ONJ), described as a serious condition involving exposed or non-healing jawbone that has been reported in some patients receiving bisphosphonate medications.
Why is this research considered important for public health?
Bisphosphonates are widely used to treat osteoporosis and to reduce skeletal complications in cancers that affect bone. The public health relevance is tied to balancing these strong therapeutic benefits with a clearer understanding of rare but severe adverse outcomes in oral and craniofacial tissues.
What grant mechanism does this opportunity use?
This opportunity uses the NIH Research Project Grant (R01) mechanism.
What does it mean that this is an R01 opportunity?
As described in the announcement summary, the R01 mechanism is typically intended for more mature, hypothesis-driven projects with a well-developed research plan, appropriate preliminary evidence, and the capacity to execute multi-year studies.
Is there a related opportunity for exploratory or early-stage projects?
Yes. The announcement notes it runs in parallel with a related FOA (PAR 06-556) that solicits applications under the R21 mechanism, which NIH used to support earlier-stage, exploratory, or higher-risk studies on the same general scientific topic.
Does this grant have a fixed budget cap or a set number of awards?
No. NIH indicated that award size and duration would vary depending on the scope of each proposed study, and it did not set a fixed budget cap or a set number of awards.
What factors determine how many awards are made and at what funding levels?
According to the announcement summary, total funding and the number of funded projects depend on typical NIH competition factors such as: the mix of applications received under the relevant mechanisms, the scientific and technical merit and overall quality of applications, the proposed project periods, and the requested costs.
What kinds of clinical study designs could fit under this opportunity?
The description indicates NIH expected a range of study designs, from smaller observational clinical studies to larger longitudinal cohorts or multi-site efforts, with different cost profiles depending on study scope.
What type of grant is this considered from an administrative standpoint?
It is described as a discretionary grant in the health research category.
What CFDA number is associated with this opportunity?
This opportunity is listed under CFDA 93.121 (Oral Diseases and Disorders Research).
Is cost sharing or matching required?
No. The announcement specifies there is no cost sharing or matching requirement.
When was the opportunity originally posted?
The FOA was originally posted on December 18, 2006.
Was there a single deadline, or were there multiple submission dates?
There were multiple receipt dates rather than a single deadline, meaning applications could be submitted on several standard NIH due dates during the active period.
Is this funding opportunity still open for new submissions?
No. The opportunity ultimately archived on December 6, 2009, which indicates it is no longer open for new submissions.
Why might this archived FOA still be useful?
Even though it is no longer open, it can still serve as a reference point for how NIH framed research needs around bisphosphonates and ONJ during that period.
Who is eligible to apply?
Eligibility is broad and includes a wide range of organizations, including: public and private institutions of higher education; nonprofit organizations (with and without 501(c)(3) status); for-profit organizations (including small businesses); state and local governments; U.S. territories and subdivisions (such as counties and special district governments); independent school districts; public housing authorities/Indian housing authorities; and Native American tribal governments and tribal organizations.
Are faith-based and community-based organizations eligible?
Yes. The announcement explicitly includes faith-based and community-based organizations as eligible applicants.
Are foreign institutions eligible to apply?
Yes. The announcement explicitly states that foreign institutions are eligible to apply.
Can U.S. federal agencies apply?
Yes. The announcement states that eligible federal agencies may apply as well.
Where were applicants directed to find full details and instructions?
Applicants were directed to the complete announcement on the NIH grants site under PA 07-185 for full details such as scientific scope, recommended research topics, application instructions, and review considerations.
Who was listed as a contact for technical difficulties accessing the announcement?
For technical difficulties accessing or linking to the announcement, NIH provided support through the Office of Extramural Research (OER) webmaster contact.
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Applicants also applied for:
Applicants who have applied for this opportunity (PA 07 185) also looked into and applied for these:
| Funding Opportunity |
|---|
| Epidemiological Research on Disorders of Hearing, Balance, Smell, Taste, Voice, Speech, and Language (R01) Apply for PA 07 251 Funding Number: PA 07 251 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Proteomics in Auditory Developmental and Disease Processes (R01) Apply for PA 07 252 Funding Number: PA 07 252 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Immunology of Biofilms (R01) Apply for PA 07 288 Funding Number: PA 07 288 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIDCD Small Grant Program (R03) Apply for PAR 07 287 Funding Number: PAR 07 287 Agency: National Institutes of Health Category: Health Funding Amount: $100,000 |
| Advances in Polycystic Kidney Disease (R01) Apply for PA 07 293 Funding Number: PA 07 293 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Preliminary Investigations Leading To Optimal Trials In Neurology (R01) Apply for PAR 07 294 Funding Number: PAR 07 294 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Hypersensitivity Pneumonitis Early Identification and Mechanisms of Disease (R01) Apply for PA 07 300 Funding Number: PA 07 300 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Mental Health Consequences Of Violence And Trauma (R01) Apply for PA 07 312 Funding Number: PA 07 312 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Mental Health Consequences of Violence and Trauma (R03) Apply for PA 07 313 Funding Number: PA 07 313 Agency: National Institutes of Health Category: Health Funding Amount: $50,000 |
| Mental Health Consequences Of Violence And Trauma (R34) Apply for PAR 07 315 Funding Number: PAR 07 315 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Mental Health Consequences Of Violence And Trauma (R21) Apply for PA 07 314 Funding Number: PA 07 314 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Stress Management Interventions to Reduce Risk of Coronary Artery Disease (R01) Apply for PA 07 322 Funding Number: PA 07 322 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Hyperglycemic Exacerbation of Ischemia/Reperfusion Injury after Ischemic Insult (R01) Apply for PA 07 323 Funding Number: PA 07 323 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Alcohol Use Disorders Treatment, Services Research, and Recovery (R03) Apply for PA 07 215 Funding Number: PA 07 215 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Pilot and Feasibility Studies on Oral Health Promotion Research across the Life Span (R21) Apply for PA 07 223 Funding Number: PA 07 223 Agency: National Institutes of Health Category: Health Funding Amount: $200,000 |
| Planning Grant for Oral Health Promotion across the Life Span (R21) Apply for PAR 07 224 Funding Number: PAR 07 224 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Oral Health Promotion Research across the Lifespan (R01) Apply for PA 07 225 Funding Number: PA 07 225 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| HIV Treatment Adherence Research (R34) Apply for PAR 07 341 Funding Number: PAR 07 341 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Collaborative Neurological Sciences (CNS) Award (S11) Apply for PAR 07 357 Funding Number: PAR 07 357 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Molecular Mechanisms of Development and Reversal of Alcohol Induced Liver Fibrosis (R01) Apply for PA 07 360 Funding Number: PA 07 360 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
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