Opportunity Information: Apply for RFA GM 13 004
Apply for RFA GM 13 004
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborations for Macromolecular Interactions in Cells (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Mar 1, 2012 and posted on Mar 1, 2012.
- Applicants must submit their applications by Jun 14, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,800,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $250,000.00 in funding.
- Eligible applicants include: Private institutions of higher education For profit organizations other than small businesses Small businesses Public housing authorities/Indian housing authorities Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments Special district governments Native American tribal organizations (other than Federally recognized tribal governments) Public and State controlled institutions of higher education State governments Independent school districts Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Collaborations for Macromolecular Interactions in Cells (R01) (Funding Opportunity Number RFA-GM-13-004) is an NIH National Institute of General Medical Sciences (NIGMS) grant opportunity meant to spark interdisciplinary, team-based research projects focused on how macromolecules interact inside living cells and how those interactions drive cellular function. The central idea is to bring together investigators with complementary expertise so that key biological questions about macromolecular function in living systems can be tackled more effectively than they could be by a single lab working alone. Rather than emphasizing the invention of brand-new tools for their own sake, the program is geared toward collaborations where the payoff is deeper biological insight into cellular mechanisms governed by macromolecular complexes and networks.
The FOA specifically encourages collaborative arrangements that integrate additional research strategies into NIGMSs existing base of laboratories studying macromolecular function in cells. Projects can be structured in several ways: first, by combining capabilities across fields such as biochemistry, genetics, chemistry, pharmacology, or related disciplines where the novelty and impact are primarily in the biological discovery enabled by the partnership. Second, teams can use the award to apply established but demanding technologies that may be expensive, technically complex, or not yet widely adopted in mainstream cell biology, with examples including mass spectrometry and high-throughput screening. Third, the announcement welcomes efforts to develop, pilot, evaluate, and/or apply emerging technologies that could open new windows into macromolecular interactions, with superresolution light microscopy offered as an example. Fourth, it also allows feasibility studies or upstream research and development on early-stage technological concepts that are still unproven but have clear potential to become useful approaches for studying macromolecular interactions in cells. Taken together, the program supports both near-term biological applications of powerful methods and earlier exploratory work that could make future interaction-focused studies possible.
This is a discretionary grant opportunity using the NIH R01 funding mechanism, categorized under Health and associated with CFDA 93.859 (Biomedical Research and Research Training). The FOA indicated an estimated total funding level of $1,800,000 and an award ceiling of $250,000 (as provided in the source data). Cost sharing or matching is not required, which is typical for NIH research project grants and reduces barriers for institutions assembling multi-lab collaborations.
Eligibility is broad and includes many types of domestic U.S. organizations such as public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain non-501(c)(3) nonprofits), small businesses and other for-profit organizations (other than small businesses are also explicitly listed), and multiple levels of government entities (state, county, city or township, special district). The announcement also notes eligibility for a wide set of mission- and community-focused institutions and organizations, including HBCUs, Hispanic-serving institutions, tribally controlled colleges and universities, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, and U.S. territories or possessions. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, and foreign components of U.S. organizations are allowed, consistent with NIH policy definitions for foreign components.
Key dates listed in the opportunity record include a posted and created date of March 1, 2012, with an original and current closing date of June 14, 2012, and an archive date of July 15, 2012. The official announcement was hosted by NIH, with a reference link to the full FOA text at http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-13-004.html. For access or technical issues related to the posting, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
In practical terms, this FOA is aimed at collaborative science that connects mechanistic cell biology questions about macromolecular interactions with the right blend of complementary expertise and enabling methods. It supports teams that either bring advanced, proven platforms into interaction-focused cell research, test and adapt emerging approaches to make them usable for these questions, or explore higher-risk concepts that could become the next generation of ways to measure, perturb, or interpret macromolecular interactions in living cellular contexts.
Frequently Asked Questions (FAQs)
What is the name of this grant opportunity?
The opportunity is titled Collaborations for Macromolecular Interactions in Cells (R01).
What is the Funding Opportunity Number (FOA number)?
The Funding Opportunity Number is RFA-GM-13-004.
Which NIH Institute is offering this opportunity?
This funding opportunity is offered by the NIH National Institute of General Medical Sciences (NIGMS).
What is the main goal of this FOA?
The central goal is to spark interdisciplinary, team-based research that explains how macromolecules interact inside living cells and how those interactions drive cellular function. The program is designed around the idea that certain key biological questions can be answered more effectively through collaborations than through a single lab working alone.
What kinds of research does this program emphasize?
The emphasis is on biological insight into cellular mechanisms governed by macromolecular complexes and networks. Rather than prioritizing brand-new tool invention for its own sake, the FOA is geared toward collaborations where the payoff is a clearer understanding of macromolecular function and interactions in living systems.
Is this intended to be a collaborative program?
Yes. The FOA is explicitly aimed at collaborative arrangements that bring together investigators with complementary expertise to tackle questions about macromolecular interactions in cells.
How can projects be structured under this FOA?
The FOA describes several acceptable structures, including:
- Combining capabilities across disciplines (for example, biochemistry, genetics, chemistry, pharmacology, or related fields), where the novelty and impact are primarily in the biological discovery enabled by the partnership.
- Applying established but demanding technologies that may be expensive, technically complex, or not yet widely used in mainstream cell biology (examples given include mass spectrometry and high-throughput screening).
- Developing, piloting, evaluating, and/or applying emerging technologies that could open new windows into macromolecular interactions (an example given is superresolution light microscopy).
- Feasibility studies or early-stage research and development on unproven concepts that have clear potential to become useful approaches for studying macromolecular interactions in cells.
Does the FOA support both applied and exploratory work?
Yes. The description supports both (1) near-term biological applications of powerful methods and (2) earlier, exploratory or feasibility-stage work intended to make future interaction-focused studies possible.
What grant mechanism is used for this opportunity?
This is a discretionary grant opportunity using the NIH R01 (Research Project Grant) mechanism.
What is the program area or category associated with this FOA?
It is categorized under Health.
What CFDA number is associated with this opportunity?
The opportunity is associated with CFDA 93.859 (Biomedical Research and Research Training).
What is the estimated total funding level?
The FOA record indicates an estimated total funding level of $1,800,000.
Is there an award ceiling?
Yes. The opportunity record lists an award ceiling of $250,000 (as provided in the source data).
Is cost sharing or matching required?
No. The FOA record states that cost sharing or matching is not required.
Who is eligible to apply?
Eligibility is broad and includes many types of domestic U.S. organizations, such as:
- Public and private institutions of higher education
- Nonprofits, including 501(c)(3) organizations and certain non-501(c)(3) nonprofits
- Small businesses
- Other for-profit organizations (other than small businesses are also explicitly listed)
- Government entities including state, county, city or township, and special district governments
Are mission- and community-focused institutions included in the eligibility list?
Yes. The announcement notes eligibility for a wide set of institutions and organizations, including:
- HBCUs (Historically Black Colleges and Universities)
- Hispanic-serving institutions
- Tribally controlled colleges and universities
- Alaska Native and Native Hawaiian Serving Institutions
- Faith-based or community-based organizations
- Regional organizations
- U.S. territories or possessions
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The information provided states that non-U.S. entities (foreign institutions) are eligible to apply.
Are foreign components of U.S. organizations allowed?
Yes. The opportunity notes that foreign components of U.S. organizations are allowed, consistent with NIH policy definitions for foreign components.
When was this FOA posted and created?
The record lists a posted and created date of March 1, 2012.
What was the closing date for applications?
The record lists an original and current closing date of June 14, 2012.
When was the opportunity archived?
The archive date is listed as July 15, 2012.
Where can applicants find the full FOA text?
The FOA text is referenced at: http://grants.nih.gov/grants/guide/rfa-files/RFA-GM-13-004.html
Who should be contacted for access or technical issues related to the posting?
For access or technical issues related to the posting, the contact provided is the NIH Office of Extramural Research (OER) webmaster at FBOWebmaster@OD.NIH.GOV.
What kinds of technologies are mentioned as examples within the FOA description?
Examples mentioned include:
- Mass spectrometry
- High-throughput screening
- Superresolution light microscopy
Does this FOA focus on inventing brand-new tools?
The description indicates that the program is not primarily about inventing new tools for their own sake. Instead, it prioritizes collaborations where the main payoff is deeper biological insight into macromolecular interactions and cellular mechanisms, while still allowing development and evaluation of emerging technologies when they enable those biological goals.
What is the practical research focus of the program?
In practical terms, it supports collaborative science that connects mechanistic cell biology questions about macromolecular interactions with the right blend of complementary expertise and enabling methods, including both advanced proven platforms and higher-risk early concepts that could become future approaches for studying interactions in living cells.
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