Opportunity Information: Apply for RFA GM 13 005
Apply for RFA GM 13 005
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Research Networks for Macromolecular Interactions in Cells (U54)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859 Biomedical Research and Research Training.
- This funding opportunity was created on Mar 1, 2012 and posted on Mar 1, 2012.
- Applicants must submit their applications by Jun 14, 2012. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: Native American tribal organizations (other than Federally recognized tribal governments) Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Independent school districts Private institutions of higher education Small businesses For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education County governments State governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Public housing authorities/Indian housing authorities Public and State controlled institutions of higher education Special district governments City or township governments.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Institutions) are eligible to apply. Non domestic (non U.S.) components of U.S. Organizations are eligible to apply. Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
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Opportunity Summary:
Research Networks for Macromolecular Interactions in Cells (U54) is a National Institutes of Health (NIH) funding opportunity issued by the National Institute of General Medical Sciences (NIGMS) to build interdisciplinary, collaborative research networks focused on how macromolecules interact inside cells and how those interactions drive cellular function. The central idea is to bring together teams whose combined expertise can answer biological questions about macromolecular function in living systems more effectively than any single lab could do alone. These networks are meant to expand and strengthen the existing NIGMS-supported community working on macromolecular biology by intentionally integrating additional research strategies, methods, and perspectives into coordinated, team-based projects.
The FOA emphasizes collaboration that is biology-driven rather than technology-driven. In practice, applicants are encouraged to assemble networks where investigators complement one another across areas such as biochemistry, genetics, chemistry, pharmacology, and related fields, using that breadth to tackle complex questions about cellular macromolecular assemblies and interaction networks. A major motivation is to enable cell and molecular biology researchers to access capabilities that are difficult to establish or sustain in a single laboratory, whether because they require specialized expertise, high cost, or operational complexity.
Four main kinds of network activities are highlighted. First, teams can combine complementary scientific strengths to pursue innovative biology, where the novelty is primarily in the questions and mechanistic insight rather than in inventing brand-new instrumentation. Second, networks can apply proven but demanding or expensive technologies that are not yet widely used in cell biology, such as advanced mass spectrometry workflows or high-throughput screening approaches, especially when those methods can reveal interaction partners, dynamic complex composition, or functional consequences of perturbations. Third, networks can develop, pilot, evaluate, and/or apply emerging technologies, with superresolution light microscopy given as an example, reflecting an interest in pushing the boundaries of what can be measured or visualized in cells while still keeping a strong focus on biological discovery. Fourth, the FOA allows feasibility studies and early-stage research and development for new technological concepts that are not yet proven but could become valuable for studying macromolecular interactions, which gives teams room to test higher-risk ideas that may unlock new experimental angles later.
Administratively, this opportunity is offered as a cooperative agreement (U54), which typically indicates substantial NIH involvement during the project, often through coordination, oversight, or partnership-like interactions to help the network meet shared goals. The opportunity falls under the health funding activity category and is associated with CFDA number 93.859 (Biomedical Research and Research Training). No cost sharing or matching is required, lowering barriers for institutions that might otherwise struggle to meet match expectations. The estimated total funding amount listed is $1,500,000, with an award ceiling of $500,000, indicating support intended for sizeable, multi-investigator network efforts rather than small single-PI projects.
Eligibility is broad and includes many types of organizations. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) organizations as well as certain nonprofits without 501(c)(3) status), small businesses and other for-profit entities, and multiple levels of government (state, county, city/township, special district), along with independent school districts and public housing authorities/Indian housing authorities. The FOA explicitly includes a wide range of mission-driven and capacity-building institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and other tribal organizations and governments. Importantly, non-U.S. entities (foreign institutions) are eligible to apply, non-U.S. components of U.S. organizations may participate, and foreign components are allowed as defined by NIH policy, which supports truly international collaborations when scientifically justified.
Key timing details reflect that this is an archived opportunity from 2012. The FOA (RFA-GM-13-005) was posted and created on March 1, 2012, with an original and current closing date of June 14, 2012, and an archive date of July 15, 2012. The full announcement was made available through the NIH Grants Guide, and technical access issues were routed through the NIH Office of Extramural Research (OER) webmaster contact.
Overall, the program can be read as a push to create coordinated, interdisciplinary teams that can map, measure, and manipulate macromolecular interactions in the cellular context, using a mix of complementary expertise and appropriately scaled technology. The emphasis is not just on using sophisticated tools, but on using them in service of clearer mechanistic understanding of how molecular interactions organize biology inside living cells.
Frequently Asked Questions (FAQs)
What is the "Research Networks for Macromolecular Interactions in Cells (U54)" opportunity?
It is a National Institutes of Health (NIH) funding opportunity from the National Institute of General Medical Sciences (NIGMS) to build interdisciplinary, collaborative research networks focused on how macromolecules interact inside cells and how those interactions drive cellular function.
Which NIH institute is sponsoring this funding opportunity?
The opportunity is issued by NIGMS (National Institute of General Medical Sciences), which is part of the NIH.
What is the main goal of these research networks?
The main goal is to bring together teams with complementary expertise so they can answer biological questions about macromolecular function in living systems more effectively than any single laboratory could do alone.
What is meant by a "research network" in this FOA?
In this context, a research network is a coordinated, team-based collaboration that integrates multiple investigators and approaches to study macromolecular interactions in cells, with the intent of producing mechanistic biological insight through combined strengths.
Is the program focused on biology questions or on technology development?
The FOA emphasizes collaboration that is biology-driven rather than technology-driven. Technology is important, but it is expected to be used in service of biological discovery and mechanistic understanding in living systems.
What kinds of expertise or disciplines does the FOA encourage networks to include?
Applicants are encouraged to assemble networks with complementary expertise across areas such as biochemistry, genetics, chemistry, pharmacology, and related fields, and to integrate additional strategies, methods, and perspectives into coordinated projects.
Why does the FOA encourage team-based projects instead of single-lab projects?
A major motivation is to enable researchers to access capabilities that are difficult to establish or sustain in a single lab due to specialized expertise needs, high cost, or operational complexity.
What are the main types of activities supported by this network program?
The FOA highlights four kinds of activities: (1) combining complementary strengths to pursue innovative biology; (2) applying proven but demanding/expensive technologies not yet widely used in cell biology; (3) developing, piloting, evaluating, and/or applying emerging technologies (with superresolution light microscopy given as an example); and (4) conducting feasibility studies and early-stage R&D for new technological concepts that are not yet proven but could become valuable for studying macromolecular interactions.
Can the network use advanced technologies like mass spectrometry or high-throughput screening?
Yes. The FOA specifically mentions applying proven but demanding or expensive technologies that are not yet widely used in cell biology, including examples such as advanced mass spectrometry workflows and high-throughput screening approaches.
Does the FOA allow work on emerging technologies?
Yes. The FOA allows networks to develop, pilot, evaluate, and/or apply emerging technologies, and provides superresolution light microscopy as an example.
Does the FOA support high-risk feasibility studies for new technological concepts?
Yes. It allows feasibility studies and early-stage research and development for new technological concepts that are not yet proven, giving teams room to test higher-risk ideas that could enable future approaches to studying macromolecular interactions.
What is the funding mechanism for this opportunity?
The opportunity is offered as a cooperative agreement (U54).
What does it mean that this is a cooperative agreement (U54)?
A cooperative agreement (U54) typically indicates substantial NIH involvement during the project, often through coordination, oversight, or partnership-like interactions to help the network meet shared goals.
What is the CFDA number associated with this opportunity?
The associated CFDA number is 93.859 (Biomedical Research and Research Training).
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
How much funding is available under this opportunity?
The estimated total funding amount listed is $1,500,000.
What is the maximum award amount (award ceiling)?
The award ceiling is $500,000.
Does the funding level suggest this is intended for single-PI projects or larger teams?
The description indicates the support is intended for sizeable, multi-investigator network efforts rather than small single-PI projects.
What types of organizations are eligible to apply?
Eligibility is broad and includes public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without 501(c)(3) status), small businesses and other for-profit entities, and multiple levels of government (state, county, city/township, and special district), as well as independent school districts and public housing authorities/Indian housing authorities.
Are minority-serving and capacity-building institutions included in eligibility?
Yes. The FOA explicitly includes institutions such as Historically Black Colleges and Universities (HBCUs), Hispanic-Serving Institutions, Alaska Native and Native Hawaiian Serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), and other tribal organizations and governments.
Are non-U.S. (foreign) organizations eligible to apply?
Yes. The FOA states that non-U.S. entities (foreign institutions) are eligible to apply.
Can foreign components participate in projects led by U.S. organizations?
Yes. Non-U.S. components of U.S. organizations may participate, and foreign components are allowed as defined by NIH policy, supporting international collaborations when scientifically justified.
What is the FOA number for this opportunity?
The FOA is identified as RFA-GM-13-005.
Is this a current funding opportunity?
No. The information provided indicates this is an archived opportunity from 2012.
What are the key dates listed for this FOA?
The FOA was posted/created on March 1, 2012. The original and current closing date is June 14, 2012. The archive date is July 15, 2012.
Where was the full announcement made available?
The full announcement was made available through the NIH Grants Guide.
Who was referenced for technical access issues related to the announcement?
Technical access issues were routed through the NIH Office of Extramural Research (OER) webmaster contact.
What is the overarching scientific focus of the program?
The program focuses on mapping, measuring, and manipulating macromolecular interactions in the cellular context, aiming for clearer mechanistic understanding of how molecular interactions organize biology inside living cells.
Is the novelty expected to come from inventing brand-new instruments?
The FOA frames one major activity area as innovative biology where novelty is primarily in the questions and mechanistic insight, not necessarily in inventing brand-new instrumentation.
What kinds of biological insights are the supported approaches meant to enable?
The examples provided emphasize revealing interaction partners, dynamic complex composition, and functional consequences of perturbations, all aimed at understanding how macromolecular assemblies and interaction networks drive cellular function.
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