Collaborative Research for Molecular and Genomic Studies of Basic Behavior in Animal Models (R01) | Apply Online

Opportunity Summary:

The grant opportunity titled "Collaborative Research for Molecular and Genomic Studies of Basic Behavior in Animal Models (R01)" (Funding Opportunity Number PA 07 096) is an NIH discretionary funding announcement led by the National Institute of General Medical Sciences (NIGMS) and the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Its core aim is to push forward research on the basic biological mechanisms that drive behavior, using animal models, by bringing together teams that normally sit in different scientific camps. In practical terms, NIH is looking for genuinely collaborative projects that pair behavioral science expertise (how to measure and interpret behavior rigorously) with molecular biology and/or genomics expertise (how to interrogate genes, gene regulation, pathways, and molecular networks). The emphasis is on basic behavior and fundamental mechanisms rather than clinical trials or purely descriptive behavioral work.

The mechanism of support is the NIH R01 research project grant, which is the standard multi-year award used to fund hypothesis-driven or discovery-driven research programs. Because projects in this area can vary widely in complexity, cost, and timeline, the announcement does not set a single budget cap or a fixed project length across all applications. Instead, NIH indicates that both the size and duration of awards may differ from one funded project to another, depending on what is scientifically justified. Likewise, NIH does not commit to a specific number of awards or a set total funding amount under this announcement; awards ultimately depend on the volume of submissions, their scientific merit, how long they propose to run, and how much they cost.

Eligibility is broad and includes many institution types. U.S.-based applicants can include public or state-controlled institutions of higher education, private universities, and a range of designated institutions such as Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Alaska Native and Native Hawaiian Serving Institutions. The opportunity is also open to nonprofit organizations both with and without 501(c)(3) status (as long as they are not institutions of higher education when applying under those categories), as well as for-profit organizations, including small businesses and other for-profit entities. Importantly, foreign (non-U.S.) organizations are explicitly eligible to apply, which signals NIH interest in supporting strong international science when it aligns with the program goals.

From an administrative standpoint, this FOA is categorized under Health, Income Security and Social Services and is associated with CFDA numbers 93.859 (Biomedical Research and Research Training) and 93.865 (Child Health and Human Development Extramural Research). There is no cost sharing or matching requirement, meaning applicants are not required to provide institutional or third-party matching funds as a condition of eligibility. The announcement was originally posted on November 28, 2006, and it uses multiple receipt dates (rather than one single deadline), directing applicants to the full announcement for the specific submission cycles. The listing indicates an archive date of February 3, 2010, which generally means the announcement is no longer active in its original form, though similar NIH program areas and reissued FOAs may exist.

Overall, the opportunity is meant to encourage research teams to combine high-quality behavioral phenotyping in animal models with modern molecular and genomic approaches to uncover how biological systems produce and regulate behavior. The key programmatic theme is collaboration across disciplines, with the expectation that integrated expertise will enable questions to be addressed that would be difficult to tackle within a single laboratory or a single methodological tradition.

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