Chronic Illness Self Management in Children and Adolescents (R03) | Apply Online

Opportunity Summary:

The Chronic Illness Self Management in Children and Adolescents (R03) opportunity (Funding Opportunity Number PA-07-098) is a National Institutes of Health (NIH) discretionary grant announcement designed to support small, focused research projects that can advance how children and adolescents learn, sustain, and succeed at managing chronic illness. It is jointly supported by several NIH components, including the National Institute of Nursing Research (NINR), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Cancer Institute (NCI), and the Office of Dietary Supplements (ODS). The central aim is to generate evidence that improves both self-management behaviors and overall quality of life for young people living with long-term health conditions.

A defining feature of this FOA is its emphasis on self-management as a long-term developmental responsibility shared initially by families and gradually assumed by the child as they mature. The announcement highlights that chronic illness management is not a short-term task; instead, it is a lifelong process focused on maintaining health, preventing complications, and supporting day-to-day functioning. Because of that reality, the FOA encourages research that looks beyond purely clinical outcomes and examines the real-world factors that shape whether children and adolescents can consistently follow complex treatment regimens, monitor symptoms, make healthy decisions, and navigate school, peer relationships, and family life while living with chronic disease.

The scientific scope is intentionally broad and encourages biobehavioral research that situates the child within family and broader community dynamics. In practice, that means studies can examine how biological factors intersect with behavior and environment, as well as how family routines, caregiver involvement, stress, communication patterns, community resources, and cultural expectations influence adherence, symptom monitoring, coping skills, and transitions in responsibility from parent to child. The FOA also explicitly welcomes work on biological and technological contributors to effective self-management, alongside sociocultural, environmental, and behavioral mechanisms. This leaves room for studies that evaluate or refine tools and strategies such as monitoring devices, digital supports, education approaches, or other interventions, as long as the work ultimately targets improved self-management and quality of life.

Eligibility and target population requirements are clearly defined. The research must focus on chronic illnesses affecting children and adolescents ages 8 to 21, with developmental stage groupings left to the investigator’s discretion. The developmental framing matters because self-management expectations and capacities differ substantially across late childhood, early adolescence, and the transition to adulthood; the FOA allows applicants to define these stages in a way that matches their disease context and research design. At the same time, the FOA draws boundaries around what it will fund: studies centered on chronic mental illness or serious cognitive disability fall outside its scope, meaning projects should focus on other chronic health conditions and avoid designs where mental illness or major cognitive impairment is the primary condition under study.

From an administrative standpoint, this is an R03 mechanism, which typically supports smaller, time-limited projects that can establish feasibility, generate preliminary data, test measures, explore mechanisms, or pilot interventions that could later be scaled through larger NIH awards. The opportunity lists multiple receipt dates rather than a single deadline, directing applicants to the full announcement for the specific submission cycles. There is no cost-sharing or matching requirement.

A wide range of applicant organizations are eligible. Eligible domestic applicants include public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), small businesses, and various levels of government (state, county, city/township, special district governments), as well as public housing authorities/Indian housing authorities. The FOA also allows applications from federally recognized tribal governments and other Native American tribal organizations. Importantly, foreign institutions are eligible to apply, and eligible federal agencies may apply as well. The announcement also specifies that faith-based and community-based organizations are eligible, which can be particularly relevant for studies grounded in community settings or culturally tailored family interventions.

The opportunity is cataloged under multiple CFDA numbers reflecting the participating NIH institutes and topical alignment, including Nursing Research (93.361), Cancer Treatment Research (93.395), and Child Health and Human Development Extramural Research (93.865). The posting timeline indicates it was originally posted November 29, 2006, with an archive date of February 2, 2010, meaning it is an older FOA and prospective applicants should verify whether a current or reissued version exists or whether similar active NIH opportunities have replaced it. The official full announcement is linked through the NIH grants site (http://grants.nih.gov/grants/guide/pa-files/PA-07-098.html), and NIH Office of Extramural Research (OER) webmaster contact information is provided for access or linking issues.

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Previous opportunity: Collaborative Research for Molecular and Genomic Studies of Basic Behavior in Animal Models (R01)

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