Opportunity Information: Apply for PA 07 099
Apply for PA 07 099
- The National Institutes of Health in the education health income security and social services sector is offering a public funding opportunity titled "Chronic Illness Self Management in Children and Adolescents (R21)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.361 Nursing Research 93.395 Cancer Treatment Research 93.865 Child Health and Human Development Extramural Research.
- This funding opportunity was created on Dec 5, 2008 and posted on Nov 30, 2006.
- Applicants must submit their applications by Multiple Receipt Dates See Link to Full Announcement for details.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Independent school districts Private institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments) City or township governments Others (see text field entitled Additional Information on Eligibility for clarification) Native American tribal governments (Federally recognized) Public housing authorities/Indian housing authorities County governments Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Public and State controlled institutions of higher education State governments.
- Foreign institutions are eligible to apply. Eligible agencies of the Federal Government can apply. Faith based or community based organizations can apply.
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Opportunity Summary:
The Chronic Illness Self Management in Children and Adolescents (R21) opportunity (Funding Opportunity Number PA-07-099) is a National Institutes of Health (NIH) exploratory/developmental grant program designed to support early-stage research that can improve self-management and quality of life for young people living with chronic physical illnesses. It is sponsored by several NIH components, including the National Institute of Nursing Research (NINR), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Cancer Institute (NCI), and the Office of Dietary Supplements (ODS). The central idea behind the announcement is that children diagnosed with long-term conditions, along with their families, must manage symptoms, treatments, and lifestyle adjustments over many years, and that better science is needed to understand what helps self-management succeed and endure across childhood, adolescence, and the transition to adulthood.
The FOA emphasizes research that looks beyond medical treatment alone and instead examines the real-world mix of influences that shape whether a child or adolescent can consistently manage a chronic illness. It specifically encourages biobehavioral studies that consider the child within their family system and within broader family-community dynamics, recognizing that daily routines, caregiving roles, communication patterns, school environments, and access to resources all affect health behaviors and outcomes. Applicants are invited to study biological and technological contributors (for example, physiologic factors, monitoring tools, adherence-support technologies), as well as sociocultural, environmental, and behavioral mechanisms that may explain why some children and families are able to maintain effective self-management over time while others struggle. The focus is on identifying modifiable factors and testing promising approaches that could reduce complications, support developmentally appropriate independence, and ultimately improve quality of life.
In terms of who and what can be studied, the scope is limited to children and adolescents with chronic illnesses between the ages of 8 and 21. Investigators have flexibility to group participants by developmental stages in a way that fits their scientific question, which is important because self-management skills, parental involvement, and social pressures can look very different at age 9 than at age 17 or 20. At the same time, the announcement clearly excludes studies focused on chronic mental illness or serious cognitive disability, placing the program squarely on chronic physical health conditions and related self-management challenges rather than psychiatric disorders or severe cognitive impairment.
This FOA uses the NIH R21 mechanism, meaning it is intended for exploratory or developmental projects that may be innovative, higher-risk, or in need of preliminary testing before a larger-scale trial or longitudinal study. It is part of a set of parallel announcements with the same scientific scope offered under different grant mechanisms: PA-07-097 for R01 (typically larger, more definitive studies) and PA-07-098 for R03 (often smaller pilot projects). Funding decisions depend on the availability of NIH funds and the number of strong applications received; the announcement does not promise a fixed number of awards, emphasizing competitiveness and scientific merit.
Eligibility is broad and includes many types of U.S. organizations such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3) entities), for-profit organizations (including small businesses), independent school districts, and various government entities at the city, county, special district, and state levels. The announcement also notes that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations are eligible as well. There is no cost-sharing or matching requirement. The opportunity was originally posted in late 2006, with multiple receipt dates (rather than a single deadline), and it was later archived in 2010, meaning it functioned as an active NIH program announcement during that period with recurring submission cycles.
Overall, PA-07-099 is best understood as a call for practical, scientifically grounded early-stage research aimed at helping young people with chronic illnesses develop and sustain the skills, supports, and routines required for long-term health. It encourages applicants to connect biology, behavior, family life, technology, and community context in ways that can produce actionable insights or testable interventions that move pediatric self-management forward.
Frequently Asked Questions (FAQs)
What is the Chronic Illness Self Management in Children and Adolescents (R21) opportunity?
It is an NIH exploratory/developmental research grant opportunity that supports early-stage studies aimed at improving self-management and quality of life for children and adolescents living with chronic physical illnesses. The funding opportunity number is PA-07-099, and it uses the NIH R21 mechanism.
What is the main purpose of PA-07-099?
The purpose is to support research that helps explain and improve how young people with chronic physical illnesses (and their families) manage symptoms, treatments, and lifestyle adjustments over time. The focus is on generating practical, scientifically grounded insights and testing promising approaches that can strengthen long-term self-management across childhood, adolescence, and the transition to adulthood.
Which NIH organizations sponsor or participate in this announcement?
The opportunity is sponsored by multiple NIH components, including the National Institute of Nursing Research (NINR), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Cancer Institute (NCI), and the Office of Dietary Supplements (ODS).
What kinds of research topics does the FOA encourage?
The FOA encourages research that goes beyond medical treatment alone and examines the mix of real-world influences that affect whether children and adolescents can consistently manage chronic illness over time. It emphasizes biobehavioral studies and invites work on biological, behavioral, technological, sociocultural, and environmental contributors that shape self-management and quality of life.
Does the announcement emphasize any particular research perspective or framework?
Yes. It emphasizes looking at the child within their family system and within broader family-community dynamics. It highlights how daily routines, caregiving roles, communication patterns, school environments, and access to resources can influence health behaviors and outcomes.
What is meant by “biobehavioral” research in the context of this FOA?
Based on the announcement description, biobehavioral research here refers to studies that connect biological and physiological factors with behavior and real-life context, such as family processes, community influences, and the tools or technologies that may support adherence and monitoring.
Are technology-related self-management supports within scope?
Yes. The FOA explicitly mentions technological contributors such as monitoring tools and adherence-support technologies as examples of factors applicants may study.
What types of factors is the FOA especially interested in identifying?
It is especially interested in modifiable factors and mechanisms that may explain why some children and families sustain effective self-management while others struggle. The intent is to support insights or approaches that could reduce complications, support developmentally appropriate independence, and improve quality of life.
Who can be studied under this FOA (age range)?
The scope is limited to children and adolescents with chronic illnesses between the ages of 8 and 21.
Can applicants define their own age or developmental groupings within 8 to 21?
Yes. Investigators have flexibility to group participants by developmental stages in ways that fit their scientific questions, recognizing that self-management and family involvement may look different across ages (for example, pre-adolescence versus later adolescence or early adulthood).
What types of conditions are included, and what is excluded?
The announcement is focused on chronic physical illnesses and related self-management challenges. It clearly excludes studies focused on chronic mental illness or serious cognitive disability.
Is the R21 mechanism intended for large, definitive clinical trials?
No. The FOA uses the NIH R21 mechanism, which is intended for exploratory or developmental projects. It is described as appropriate for innovative, higher-risk work and for preliminary testing before a larger-scale trial or longer-term study.
Are there related opportunities using other NIH grant mechanisms for the same scientific scope?
Yes. The FOA is part of a set of parallel announcements with the same scientific scope offered under different mechanisms: PA-07-097 (R01) and PA-07-098 (R03).
How are funding decisions made under this announcement?
Funding decisions depend on the availability of NIH funds and the number of strong applications received. The announcement does not promise a fixed number of awards and emphasizes competitiveness and scientific merit.
What types of organizations are eligible to apply?
Eligibility is broad and includes many types of U.S. organizations, such as public and private institutions of higher education, nonprofits (including 501(c)(3) and non-501(c)(3)), for-profit organizations (including small businesses), independent school districts, and government entities at the city, county, special district, and state levels.
Are foreign institutions eligible to apply?
Yes. The announcement notes that foreign institutions are eligible to apply.
Can federal agencies apply?
Yes. The announcement states that eligible federal agencies may apply.
Are faith-based or community-based organizations eligible?
Yes. The FOA specifies that faith-based and community-based organizations are eligible.
Is there a cost-sharing or matching requirement?
No. The announcement states there is no cost-sharing or matching requirement.
Were there single or multiple deadlines for submission?
The opportunity used multiple receipt dates rather than a single deadline, indicating recurring submission cycles during the time it was active.
When was the opportunity posted, and what does it mean that it was archived?
It was originally posted in late 2006 and later archived in 2010. “Archived” indicates it functioned as an active NIH program announcement during that period and is no longer active as a current funding opportunity.
What is the overall takeaway of PA-07-099?
It is a call for early-stage, practical research on pediatric and adolescent chronic illness self-management that integrates biology, behavior, family life, technology, and community context, with the goal of producing actionable insights or testable interventions that improve long-term health and quality of life.
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| Chronic Illness Self Management in Children and Adolescents (R01) Apply for PA 07 097 Funding Number: PA 07 097 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
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| The Influence of Religiosity and Spirituality on Health Risk Behaviors in Children and Adolescents (R01) Apply for PA 07 181 Funding Number: PA 07 181 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
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| Research on Social Work Practice and Concepts in Health (R01) Apply for PA 07 292 Funding Number: PA 07 292 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Developmental Psychopharmacology (R21) Apply for PA 07 222 Funding Number: PA 07 222 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Psychosocial/Behavioral Interventions and Services Research in Autism Spectrum Disorders (R34) Apply for PA 07 343 Funding Number: PA 07 343 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R21) Apply for PA 07 391 Funding Number: PA 07 391 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Reducing Health Disparities Among Minority and Underserved Children (R01) Apply for PA 07 392 Funding Number: PA 07 392 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
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| The Science and Ecology of Early Development (SEED) R03 Apply for PA 08 068 Funding Number: PA 08 068 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
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| Prevention Research with HIV Positive Individuals (R03) Apply for PA 08 108 Funding Number: PA 08 108 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Prevention Research with HIV Positive Individuals (R21) Apply for PA 08 109 Funding Number: PA 08 109 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
| Dissemination, Implementation, and Operational Research for HIV Prevention Interventions (R01) Apply for PA 08 166 Funding Number: PA 08 166 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Collaborative HIV/AIDS Studies in the Middle East and North Africa (R21) Apply for PAR 08 153 Funding Number: PAR 08 153 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: $200,000 |
| Technological Innovations for Interdisciplinary Research Incorporating the Behavioral and Social Sciences (SBIR R43/R44) Apply for PAR 08 202 Funding Number: PAR 08 202 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
| Impact of Health Communication Strategies on Dietary Behaviors (R01) Apply for PA 08 239 Funding Number: PA 08 239 Agency: National Institutes of Health Category: Education Health Income Security and Social Services Funding Amount: Case Dependent |
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