Chronic Illness Self Management in Children and Adolescents (R01) | Apply Online

Opportunity Summary:

The Chronic Illness Self Management in Children and Adolescents (R01) funding opportunity (PA-07-097) is an NIH research grant announcement focused on improving self-management and quality of life for young people living with chronic physical health conditions. It is sponsored by multiple NIH partners, including the National Institute of Nursing Research (NINR), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), the National Cancer Institute (NCI), and the Office of Dietary Supplements (ODS). The central idea is that children and teens with chronic illnesses, along with their families, carry long-term responsibility for daily disease management, and research is needed to strengthen the skills, supports, and systems that make that management effective and sustainable over a lifetime.

The announcement encourages studies that look beyond medical treatment alone and instead investigate the real-world factors that shape whether self-management works in everyday life. A major emphasis is on biobehavioral research, especially research that examines children within the context of their families and the broader family-community environment. This means applicants are encouraged to consider how family routines, parenting practices, communication, school and neighborhood contexts, peer influences, and access to resources interact with a child or adolescent's biology, symptoms, and treatment demands. The goal is to generate knowledge and interventions that help young people maintain health, prevent complications, and improve overall well-being as they grow into adulthood.

Research topics can include biological and technological contributors to self-management, as well as sociocultural, environmental, and behavioral mechanisms. In practice, this could involve studying how developmental stage affects adherence, how technology (such as monitoring devices, mobile tools, or telehealth supports) can help families manage complex regimens, or how social determinants and cultural factors influence sustained behavior change. The FOA is intentionally broad in its scientific scope as long as the proposed work aims to improve self-management and quality of life for pediatric and adolescent populations with chronic illness and produces actionable insights or strategies that can be translated into better outcomes.

The eligible participant population is limited to children and adolescents ages 8 through 21, and investigators may group participants by developmental stage in ways that make sense for their study design (for example, middle childhood, early adolescence, late adolescence, and emerging adulthood). At the same time, the FOA clearly excludes certain areas: studies centered on chronic mental illness or serious cognitive disability are considered outside the scope. The emphasis is on chronic illnesses where self-management behaviors and family-supported management are key to preventing complications and promoting long-term health.

This opportunity uses the NIH Research Project Grant (R01) mechanism, which typically supports larger, more comprehensive research projects compared with smaller exploratory or pilot mechanisms. The FOA is described as running in parallel with companion announcements of the same scientific scope that use other mechanisms, specifically an R21 version (PA-07-099) and an R03 version (PA-07-098). That structure allows investigators to align the scale of their project with the appropriate grant type, while still addressing the same overall research goals.

Funding under this FOA is not guaranteed and depends on congressional appropriations, institute priorities, and the availability of funds, as well as the number and quality of applications received. In other words, awards are made competitively, and NIH anticipates making awards only if enough scientifically strong, relevant proposals are submitted.

Administratively, this is a discretionary grant opportunity posted on November 30, 2006, with multiple receipt dates rather than a single deadline, meaning applications can be submitted according to NIH’s standard recurring submission cycles (as specified in the full announcement). It does not require cost sharing or matching funds. The opportunity is listed under several CFDA numbers reflecting the participating NIH areas, including nursing research, cancer treatment research, and child health and human development research.

Eligibility is broad and includes many types of organizations that commonly apply for NIH funding. Eligible applicants include public and private institutions of higher education, nonprofits (including 501(c)(3) organizations and certain nonprofits without that status), state and local governments, tribal governments and tribal organizations, independent school districts, public housing authorities/Indian housing authorities, small businesses, and other for-profit organizations in some cases. The announcement also specifies that foreign institutions are eligible to apply, eligible federal agencies may apply, and faith-based or community-based organizations may apply, which expands the pool of potential applicants beyond traditional academic medical centers.

For applicants needing the official details, the full announcement is available through the NIH grants guide at http://grants.nih.gov/grants/guide/pa-files/PA-07-097.html. The notice also provides an NIH Office of Extramural Research (OER) contact email for technical problems accessing or linking to the announcement (FBOWebmaster@od.nih.gov).

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Next opportunity: Prioritizing Molecular Targets for Cancer Prevention with Nutritional Combinations (R01)

Previous opportunity: Chronic Illness Self Management in Children and Adolescents (R21)

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