Opportunity Information: Apply for RFA AA 17 014
Apply for RFA AA 17 014
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (U01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273.
- This funding opportunity was created on Sep 23, 2016.
- Applicants must submit their applications by Dec 02, 2016. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- The number of recipients for this funding is limited to 5 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Opportunity Summary:
The Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (U01) funding opportunity (RFA-AA-17-014) was a National Institutes of Health initiative under the Department of Health and Human Services, led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA). It was released to stimulate new, collaborative research focused on how alcohol use affects HIV/AIDS and a range of health conditions that frequently occur alongside HIV. The overarching aim was to improve how these interconnected problems are identified, analyzed, and treated, with a strong emphasis on research that can clarify mechanisms, inform clinical care, and ultimately improve outcomes for people living with HIV who also experience alcohol-related risks or alcohol use disorders.
A central feature of the announcement was its emphasis on building collaborations that bridge existing expertise. Specifically, the FOA sought to foster research partnerships between investigators already supported by NIAAA and investigators who were not currently part of NIAAA's HIV/AIDS research portfolio. In practical terms, the opportunity was designed to bring fresh perspectives and complementary skill sets into NIAAA-relevant HIV research, such as combining HIV clinical or epidemiologic expertise with alcohol research, behavioral science, implementation science, pharmacology, or comorbidity-focused clinical research. The expectation was that team science would accelerate progress on complex, real-world problems that sit at the intersection of HIV, alcohol, and other co-occurring conditions.
In terms of scientific scope, the FOA targeted research on HIV/AIDS and comorbidities that are influenced by alcohol use. Examples highlighted in the announcement included hepatitis C virus (HCV), tuberculosis (TB), depression, HIV-associated neurocognitive disorders (HAND), and other substance use. It also explicitly pointed to medication polypharmacy, reflecting concern about the clinical complexity many people with HIV face when managing antiretroviral therapy alongside treatments for mental health conditions, infectious comorbidities, pain, and substance use disorders. Research responsive to the FOA would therefore be expected to address not only HIV outcomes, but also the ways alcohol can worsen comorbidity risk, complicate treatment adherence, interact with medications, or intensify behavioral and biological pathways that drive disease progression and poorer health.
The funding mechanism was a cooperative agreement (U01), which generally indicates a more substantial level of scientific or programmatic involvement by the NIH compared with a standard research project grant. The cooperative agreement structure is commonly used when NIH anticipates the need for close coordination, collaboration across sites or disciplines, shared resources, or harmonized methods to meet the program's goals. Under this structure, awardees typically conduct the research, but with active engagement from the funding institute to facilitate collaboration, align efforts with program priorities, and support progress toward the initiative's objectives.
The opportunity fell under the Health funding activity category and was associated with CFDA number 93.273. The award ceiling listed for this FOA was $500,000, and the NIH expected to make about five awards, signaling a competitive program with a limited number of funded projects and a focus on relatively substantial, well-scoped collaborative studies. The announcement was created on September 23, 2016, with an original application closing date of December 2, 2016, placing it in the context of NIH's mid-2010s efforts to address HIV as a chronic condition complicated by behavioral health factors and multiple comorbidities.
Eligibility was broad and included many types of domestic entities, reflecting a desire to attract proposals from a wide scientific and service-delivery landscape. Eligible applicants included state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses, with additional eligibility details referenced in the FOA's supplemental text. This wide eligibility range would allow traditional academic research teams, community-engaged partnerships, healthcare systems, and other research-capable organizations to propose projects, including those positioned to study real-world clinical settings where HIV, alcohol use, and comorbidities intersect.
Overall, the FOA can be understood as an effort to push the field toward integrated, multidisciplinary HIV research that takes alcohol use seriously as a driver of risk, disease burden, and treatment complexity. By incentivizing collaborations between NIAAA-funded investigators and those new to NIAAA's HIV/AIDS efforts, the program aimed to catalyze novel approaches and expand the network of researchers tackling alcohol-related HIV comorbidities, with attention to both biological and behavioral dimensions and to the practical realities of treating patients managing multiple conditions and medications at once.
FAQs: Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (U01) - RFA-AA-17-014
What is RFA-AA-17-014?
RFA-AA-17-014 is a National Institutes of Health (NIH) funding opportunity announcement for the initiative titled "Collaborative Research in HIV/AIDS, Alcohol, and Related Comorbidities (U01)." It was released under the U.S. Department of Health and Human Services and led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
What was the main purpose of this funding opportunity?
The purpose was to stimulate new, collaborative research on how alcohol use affects HIV/AIDS and health conditions that commonly occur alongside HIV. The overall goal was to improve identification, analysis, and treatment of these interconnected problems, with an emphasis on clarifying mechanisms, informing clinical care, and improving outcomes for people living with HIV who also face alcohol-related risks or alcohol use disorders.
Which NIH institute led this initiative?
The initiative was led by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), an institute within NIH.
What type of funding mechanism was used?
This opportunity used a cooperative agreement mechanism (U01). A U01 typically involves substantial NIH scientific or programmatic involvement compared with a standard research project grant, and it is often used when close coordination, collaboration across sites or disciplines, shared resources, or harmonized methods are expected.
What does the cooperative agreement (U01) structure imply for awardees?
Under a U01, awardees generally conduct the research while NIH (through the funding institute) is actively engaged to facilitate collaboration, help align efforts with program priorities, and support progress toward the initiative's objectives.
What research areas were encouraged by the announcement?
The scientific scope focused on HIV/AIDS and comorbidities influenced by alcohol use. The announcement emphasized research that examines how alcohol can worsen comorbidity risk, complicate treatment adherence, interact with medications, or intensify behavioral and biological pathways linked to disease progression and poorer health outcomes.
What comorbidities were specifically mentioned as examples?
Examples highlighted included hepatitis C virus (HCV), tuberculosis (TB), depression, HIV-associated neurocognitive disorders (HAND), and other substance use. The announcement also pointed to medication polypharmacy as an important area of concern.
What is meant by medication polypharmacy in this context?
Medication polypharmacy refers to the clinical complexity of managing multiple medications at once. In this context, it reflects concerns about people with HIV who may be taking antiretroviral therapy alongside treatments for mental health conditions, infectious comorbidities, pain, and substance use disorders, and how alcohol use may complicate those regimens.
Why did the FOA emphasize collaboration?
The announcement aimed to accelerate progress on complex, real-world problems at the intersection of HIV, alcohol, and co-occurring conditions. It promoted "team science" and partnerships that bridge different areas of expertise, such as combining HIV clinical or epidemiologic strengths with alcohol research, behavioral science, implementation science, pharmacology, or comorbidity-focused clinical research.
What kinds of collaborations were specifically encouraged?
A central feature was encouraging partnerships between investigators already supported by NIAAA and investigators who were not currently part of NIAAA's HIV/AIDS research portfolio. The intent was to bring fresh perspectives and complementary skill sets into NIAAA-relevant HIV research.
What kinds of organizations were eligible to apply?
Eligibility was broad and included many domestic entities, including state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments and other tribal organizations; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. Additional eligibility details were referenced in the FOA's supplemental text.
Was this opportunity limited to academic institutions?
No. The eligible applicant list included universities, nonprofits, government entities, tribal governments and organizations, housing authorities, and for-profit entities (including small businesses), reflecting an intent to attract proposals from a wide research and service-delivery landscape.
What funding activity category was associated with this opportunity?
The opportunity fell under the Health funding activity category.
What CFDA number was associated with this initiative?
The FOA was associated with CFDA number 93.273.
What was the award ceiling for this FOA?
The award ceiling listed for this funding opportunity was $500,000.
How many awards were expected to be made?
NIH expected to make about five awards, indicating a competitive opportunity with a limited number of funded projects.
When was the announcement created and when did it close?
The announcement was created on September 23, 2016. The original application closing date was December 2, 2016.
What outcomes or impacts was the program trying to achieve?
The program aimed to push HIV research toward integrated, multidisciplinary approaches that treat alcohol use as a meaningful driver of risk, disease burden, and treatment complexity. By encouraging new collaborations, it sought to catalyze novel approaches, expand the network of researchers working on alcohol-related HIV comorbidities, and support research that could clarify mechanisms, inform clinical care, and improve health outcomes.
Did the FOA focus only on HIV outcomes?
No. While HIV/AIDS was central, the FOA emphasized research that also addresses comorbidities and the ways alcohol can worsen those conditions or complicate care, including adherence and medication interactions.
What types of expertise were mentioned as valuable for responsive research teams?
The announcement pointed to combining HIV clinical or epidemiologic expertise with complementary areas such as alcohol research, behavioral science, implementation science, pharmacology, and comorbidity-focused clinical research.
Why was this initiative positioned as important in the mid-2010s context?
It was framed as part of NIH's mid-2010s efforts to address HIV as a chronic condition complicated by behavioral health factors and multiple comorbidities, particularly where alcohol use can influence health trajectories and treatment complexity.
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