Opportunity Information: Apply for RFA HL 11 002
Apply for RFA HL 11 002
- The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Common Pathogenetic Mechanisms of Lung Cancer and COPD (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.396 Cancer Biology Research 93.838 Lung Diseases Research.
- This funding opportunity was created on Mar 2, 2010 and posted on Mar 2, 2010.
- Applicants must submit their applications by Jun 18, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The funding agency has allocated a total of $24,000,000.00 to eligible and selected applicants.
- The number of recipients for this funding is limited to 8 candidate(s).
- Eligible applicants include: County governments City or township governments Native American tribal organizations (other than Federally recognized tribal governments) Independent school districts Private institutions of higher education State governments Others (see text field entitled Additional Information on Eligibility for clarification) Public housing authorities/Indian housing authorities For profit organizations other than small businesses Small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Special district governments Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education.
- Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Indian/Native American Tribal Governments (Other than Federally Recognized) Non domestic (non U.S.) Entities (Foreign Organizations) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:
The Common Pathogenetic Mechanisms of Lung Cancer and COPD (R01) funding opportunity (RFA-HL-11-002) is a National Institutes of Health discretionary grant initiative jointly sponsored by the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI). It supports investigator-driven R01 research projects aimed at explaining why lung cancer and Chronic Obstructive Pulmonary Disease (COPD) so often occur in the same individuals and share overlapping risk profiles, especially in the context of exposures like cigarette smoke. The central scientific goal is to identify the fundamental etiopathogenetic links between the two diseases, rather than studying them as isolated conditions, and to use those insights to clarify disease origins, progression, and potentially future prevention or early detection strategies.
The FOA is focused on two major lines of inquiry. First, it seeks studies that define the genotypic and phenotypic features that determine individual susceptibility, meaning the inherited genetic factors and observable traits or biological signatures that may predispose certain people to develop COPD, lung cancer, or both. Second, it encourages research that maps the shared biochemical, molecular, and immunological pathways involved in the initiation and progression of both diseases. In practical terms, the NIH is looking for mechanistic work that can explain common processes such as chronic inflammation, immune dysregulation, oxidative stress, tissue remodeling, altered cell signaling, impaired repair mechanisms, or other convergent pathways that could plausibly drive both COPD pathology and tumor development in the lung.
The mechanism of support is the standard NIH Research Project Grant (R01), which is designed to fund hypothesis-driven, multi-year research programs carried out by a defined research team at an eligible institution. No cost sharing or matching is required. The anticipated federal investment totals up to $24,000,000 in total costs over four years, with NHLBI intending to commit up to $12,000,000 and NCI also intending to commit up to $12,000,000 across that same period. The program projected up to eight total awards, indicating a competitive funding environment aimed at a relatively small number of high-impact projects.
Eligibility is broad and includes a wide range of domestic and non-domestic institutions and organizations. Eligible applicants include public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status, other than institutions of higher education), for-profit organizations (including small businesses and other than small businesses), and multiple levels of government (state, county, city/township, special district). The FOA also explicitly includes many mission-focused and underrepresented-serving entities, such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, tribal governments (federally recognized and other than federally recognized), and faith-based or community-based organizations. It also allows non-U.S. entities (foreign organizations), regional organizations, and U.S. territories or possessions, reflecting an intent to attract strong science regardless of geography, provided the application aligns with NIH requirements.
From an administrative standpoint, the opportunity was posted and created on March 2, 2010, with an original and current closing date of June 18, 2010, and an archive date of July 19, 2010. The activity sits at the intersection of lung disease and cancer research and is associated with CFDA numbers covering cancer cause and prevention research (93.393), cancer biology research (93.396), and lung diseases research (93.838). The official announcement and full details were provided through the NIH Grants Guide, and technical access questions were routed to the NIH Office of Extramural Research webmaster contact.
FAQs: Common Pathogenetic Mechanisms of Lung Cancer and COPD (R01) - RFA-HL-11-002
What is this funding opportunity?
This is an NIH discretionary grant initiative titled "The Common Pathogenetic Mechanisms of Lung Cancer and COPD (R01)" (RFA-HL-11-002). It supports investigator-driven R01 research projects focused on shared disease mechanisms between lung cancer and Chronic Obstructive Pulmonary Disease (COPD).
Which NIH institutes are sponsoring this opportunity?
The opportunity is jointly sponsored by the National Heart, Lung, and Blood Institute (NHLBI) and the National Cancer Institute (NCI).
What is the main scientific purpose of the FOA?
The central goal is to explain why lung cancer and COPD frequently occur in the same individuals and share overlapping risk profiles, particularly in relation to exposures such as cigarette smoke. The FOA emphasizes identifying fundamental etiopathogenetic links between the two diseases rather than treating them as isolated conditions.
What type of research projects does it support?
It supports hypothesis-driven, multi-year R01 research programs carried out by a defined research team at an eligible institution. The projects are expected to be mechanistic and aimed at clarifying disease origins and progression, and potentially informing future prevention or early detection strategies.
What are the two major lines of inquiry emphasized by the FOA?
The FOA focuses on: (1) defining genotypic and phenotypic features that determine individual susceptibility to COPD, lung cancer, or both; and (2) mapping shared biochemical, molecular, and immunological pathways involved in initiation and progression of both diseases.
What does "genotypic and phenotypic features" mean in the context of this FOA?
In this FOA, genotypic features refer to inherited genetic factors, while phenotypic features refer to observable traits or biological signatures that may predispose individuals to develop COPD, lung cancer, or both.
What kinds of shared mechanisms or pathways are of interest?
The NIH is looking for mechanistic explanations of convergent processes that could plausibly drive both COPD pathology and lung tumor development. Examples mentioned include chronic inflammation, immune dysregulation, oxidative stress, tissue remodeling, altered cell signaling, and impaired repair mechanisms.
Is the FOA specifically interested in exposure-related risk, such as cigarette smoke?
Yes. The opportunity highlights overlapping risk profiles "especially in the context of exposures like cigarette smoke" as a key motivation for investigating shared mechanisms.
What is the funding mechanism?
The mechanism of support is the NIH Research Project Grant (R01).
How much total funding is anticipated for this initiative?
The anticipated federal investment is up to $24,000,000 in total costs over four years.
How is the total investment split between NHLBI and NCI?
NHLBI intended to commit up to $12,000,000 and NCI also intended to commit up to $12,000,000 over the same four-year period.
How many awards were expected?
The program projected up to eight total awards, suggesting a competitive environment focused on a relatively small number of high-impact projects.
Is cost sharing or matching required?
No. The FOA states that no cost sharing or matching is required.
Who is eligible to apply?
Eligibility is broad and includes domestic and non-domestic institutions and organizations, including higher education institutions, nonprofit and for-profit organizations, and multiple levels of government.
Are institutions of higher education eligible?
Yes. Eligible applicants include both public and state-controlled institutions of higher education and private institutions of higher education.
Are nonprofit organizations eligible?
Yes. Nonprofit organizations are eligible, including those with and without 501(c)(3) status (other than institutions of higher education).
Are for-profit organizations eligible?
Yes. For-profit organizations are eligible, including small businesses and other than small businesses.
Are government entities eligible?
Yes. Eligibility includes state governments, county governments, city or township governments, and special district governments.
Are underrepresented-serving and mission-focused institutions included?
Yes. The FOA explicitly includes entities such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and tribal governments (federally recognized and other than federally recognized).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly included among eligible applicants.
Can non-U.S. organizations apply?
Yes. The FOA allows non-U.S. entities (foreign organizations), as well as regional organizations, and applicants from U.S. territories or possessions.
What are the key dates for this opportunity?
The opportunity was posted and created on March 2, 2010. The original and current closing date was June 18, 2010. The archive date was July 19, 2010.
Is this opportunity still open?
Based on the provided dates (closing date June 18, 2010 and archive date July 19, 2010), this FOA is not open for new applications.
Which CFDA numbers are associated with this FOA?
The FOA is associated with CFDA numbers 93.393 (cancer cause and prevention research), 93.396 (cancer biology research), and 93.838 (lung diseases research).
Where were the official announcement and full details posted?
The official announcement and full details were provided through the NIH Grants Guide.
Who was the contact for technical access questions?
Technical access questions were routed to the NIH Office of Extramural Research webmaster contact.
What is the overall research theme tying projects together?
The overarching theme is understanding shared etiopathogenetic mechanisms linking COPD and lung cancer, including why they co-occur, how shared pathways may drive both disease processes, and how these insights could clarify disease origins and progression.
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