Community Clinical Oncology Program Groups (U10) | Apply Online

Opportunity Summary:

The Community Clinical Oncology Program Groups (U10) funding opportunity (RFA-CA-11-006) is a National Institutes of Health, National Cancer Institute cooperative agreement aimed at strengthening and expanding the NCI-supported Community Clinical Oncology Program (CCOP) Network through organizations that function as "accrual groups." In practical terms, the program is designed to support institutions and community-based oncology partners that can enroll (accrue) patients and participants into NCI-supported clinical trials and related research, especially in settings outside major academic medical centers. CCOP, originally established in 1983, was built around the idea that high-quality cancer clinical research should be conducted where many patients actually receive care: in the community. This FOA focuses on enabling community oncology systems to participate meaningfully in state-of-the-art cancer prevention, cancer control, and cancer treatment trials, while also helping research findings move faster into routine clinical practice.

The core goals of the CCOP Network described in the announcement center on three connected outcomes. First, the network seeks to accelerate the development of interventions that prevent or treat cancer, as well as interventions that address cancer-related symptoms, by increasing enrollment into clinical trials. Higher accrual generally means trials can answer research questions sooner and with stronger evidence, which can speed improvements in care. Second, the network aims to foster higher quality cancer care in community settings by promoting the adoption of results generated from clinical trials. The underlying concept is that when community clinicians are active partners in trials, it becomes easier to implement evidence-based practices locally once results are available. Third, the CCOP Network emphasizes increasing participation of minority and underserved populations in cancer clinical trials and associated research, reflecting longstanding concerns that clinical research participation often does not match the diversity of the populations affected by cancer. By supporting community-based accrual groups, the program intends to reduce barriers to participation and improve the representativeness of research findings.

From an administrative standpoint, this opportunity uses a cooperative agreement mechanism (U10), which typically indicates substantial programmatic involvement by the funding agency compared with a standard grant. While the announcement text provided does not spell out operational details, the cooperative agreement structure usually means awardees work closely with NCI staff on expectations such as trial activation, performance metrics, reporting, and adherence to network policies and procedures. The FOA notes that the CCOP Network has three components and that each component has its own separate FOA, positioning this particular announcement specifically for CCOP "Groups" serving as accrual organizations within the broader network.

The opportunity was posted on May 24, 2011, with an original and current closing date of July 27, 2011, and it was archived on August 27, 2011. The estimated total funding listed is $14,300,000. It falls under the broad activity areas of education and health, and it is associated with multiple CFDA program areas tied to the cancer research continuum: 93.393 (Cancer Cause and Prevention Research), 93.394 (Cancer Detection and Diagnosis Research), 93.395 (Cancer Treatment Research), and 93.399 (Cancer Control). The announcement indicates there is no cost-sharing or matching requirement, meaning applicants are not required to commit their own funds as a condition of the award.

Eligibility is broad across U.S.-based organizational types, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), and for-profit organizations other than small businesses. The eligibility language also explicitly includes a wide range of community-focused and mission-driven institutions such as faith-based or community-based organizations, regional organizations, and eligible federal agencies. It further calls out specific categories of institutions often emphasized in federal capacity-building and equity efforts, including Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, tribally controlled colleges and universities (TCCUs), and tribal governments and tribal organizations (including federally recognized tribal governments and other tribal government structures). U.S. territories or possessions are also included as eligible. At the same time, the FOA clearly excludes non-U.S. entities: foreign organizations are not eligible to apply, and foreign components of U.S. organizations are not allowed, reinforcing that the supported accrual and operations are intended to be domestic.

Overall, this FOA is best understood as an effort to expand the reach and impact of NCI clinical research by formally integrating community oncology practices and their patient populations into a national clinical trials infrastructure. The emphasis on accrual, translation of trial results into community care, and increased inclusion of minority and underserved populations signals that applicants were expected not only to enroll participants effectively, but also to demonstrate the capability to deliver high-quality research participation in real-world community settings and to strengthen equitable access to trials. For full details, the announcement directs applicants to the NIH Grants Guide posting for RFA-CA-11-006 and provides NIH Office of Extramural Research webmaster contacts for technical access issues.

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