Opportunity Information: Apply for RFA CA 11 007

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Community Clinical Oncology Program Research Bases (U10)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.399 Cancer Control.
  • This funding opportunity was created on May 24, 2011 and posted on May 24, 2011.
  • Applicants must submit their applications by Jul 28, 2011. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $42,600,000.00 to eligible and selected applicants.
  • Eligible applicants include: Private institutions of higher education For profit organizations other than small businesses Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education Others (see text field entitled Additional Information on Eligibility for clarification) Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Public and State controlled institutions of higher education Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Regional Organizations Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession Non domestic (non U.S.) Entities (Foreign Organizations) are not eligible to apply. Foreign (non U.S.) components of U.S. Organizations are not allowed.
Apply for RFA CA 11 007

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Opportunity Summary:

The Community Clinical Oncology Program (CCOP) Research Bases (U10) funding opportunity (RFA-CA-11-007) was issued by the National Institutes of Health (NIH), specifically through the National Cancer Institute (NCI), to support institutions that would function as the central "research base" hubs within the NCI-supported CCOP Network. The larger purpose of CCOP was to bring high-quality, cutting-edge cancer clinical research into community settings by actively involving community oncologists and the patient populations they serve, rather than limiting major trials to large academic medical centers. In practical terms, this program was designed to speed the translation of research into everyday oncology practice and to broaden access to cancer prevention, cancer control, and cancer treatment trials for patients who receive care in community clinics.

Within the CCOP Network, this particular announcement focused on the Research Bases component, which plays a distinct role compared to the other two network components. CCOP Groups (also called CCOPs) are the community-based providers and practices that enroll, or accrue, patients and participants onto NCI-approved clinical trials. Minority-Based CCOPs are similar in function to CCOP Groups but are specifically organized around communities with a high proportion of minority patients, with the goal of improving participation and representation of underserved populations in clinical research. The CCOP Research Bases supported under this FOA are the entities responsible for designing and conducting the trials themselves, coordinating their implementation across participating community sites, managing and analyzing trial data, and reporting results. In other words, these Research Bases serve as the scientific and operational backbone of the community trial network, ensuring that trials are properly developed, run consistently across sites, and evaluated rigorously.

A key structural requirement in this announcement is that applicants proposing to be CCOP Research Bases had to be located either at an NCI-supported Clinical Cooperative Group or at an NCI-designated Cancer Center. That condition reflects the expectation that Research Bases would have the established infrastructure and expertise needed for multicenter clinical trial development and oversight, including protocol development capacity, regulatory compliance, data management systems, statistical analysis support, and experience coordinating multiple participating sites. The FOA also emphasizes that the trials in scope span cancer prevention, detection/diagnosis, treatment, and control, aligning with multiple cancer-related CFDA program areas (93.393, 93.394, 93.395, and 93.399).

From a funding mechanics standpoint, this opportunity used the U10 cooperative agreement mechanism, meaning it was not a simple grant where the awardee operates independently; instead, it implies substantial scientific or programmatic involvement by NCI during the conduct of the funded activities. The opportunity was categorized as discretionary funding, and it did not require cost sharing or matching funds. The estimated total funding level listed for the announcement was $42,600,000, reflecting the scale of infrastructure and network coordination expected for Research Bases supporting national community oncology trials.

Eligibility was broad across many types of U.S.-based institutions and organizations, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, tribal governments and tribal organizations, faith-based and community-based organizations, and several categories of minority-serving institutions (such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities). Regional organizations and eligible federal agencies were also included among eligible applicants as described. At the same time, the FOA clearly excluded non-U.S. entities: foreign organizations were not eligible to apply, and foreign components of U.S. organizations were not allowed.

In terms of timing and status, the FOA was posted and created on May 24, 2011, with an original and final application due date of July 28, 2011. The opportunity was later archived on August 28, 2011. The official full announcement was made available through the NIH Grants Guide (via the link provided in the source text), and NIH Office of Extramural Research (OER) webmaster contact information was included for technical access or linking issues.

Overall, this announcement sought to fund the entities that would originate and manage the clinical trial portfolio for the CCOP Network, ensuring that community oncologists could enroll patients onto NCI-approved studies that were centrally designed, coordinated, and analyzed by well-equipped Research Bases situated within major NCI-supported research structures.

Frequently Asked Questions (FAQs)

What is the CCOP Research Bases (U10) funding opportunity (RFA-CA-11-007)?

This funding opportunity was issued by the National Institutes of Health (NIH) through the National Cancer Institute (NCI) to support institutions that would serve as the central "research base" hubs within the NCI-supported Community Clinical Oncology Program (CCOP) Network. These funded Research Bases were expected to provide the scientific and operational backbone for community-based cancer clinical research.

What was the purpose of the broader CCOP program?

The broader purpose of CCOP was to bring high-quality, cutting-edge cancer clinical research into community settings by actively involving community oncologists and the patient populations they serve. CCOP aimed to speed the translation of research findings into everyday oncology practice and broaden access to cancer prevention, cancer control, and cancer treatment trials for patients receiving care in community clinics.

What role does a CCOP Research Base play within the CCOP Network?

CCOP Research Bases were responsible for designing and conducting clinical trials, coordinating trial implementation across participating community sites, managing and analyzing trial data, and reporting results. In practical terms, they originated and managed the clinical trial portfolio and ensured consistent, rigorous execution and evaluation across multiple community locations.

How are CCOP Research Bases different from CCOP Groups?

CCOP Groups (also called CCOPs) are the community-based providers and practices that enroll (accrue) patients and participants onto NCI-approved clinical trials. By contrast, CCOP Research Bases design and run the trials themselves and coordinate and analyze the work across the community sites.

How are CCOP Research Bases different from Minority-Based CCOPs?

Minority-Based CCOPs function similarly to CCOP Groups in that they accrue patients onto NCI-approved clinical trials, but they are specifically organized around communities with a high proportion of minority patients to improve participation and representation of underserved populations in clinical research. Research Bases, meanwhile, develop and manage the trials across sites.

What kinds of clinical trials and research areas were within scope for this announcement?

The FOA emphasized trials spanning cancer prevention, detection/diagnosis, treatment, and control. It also aligned with multiple cancer-related CFDA program areas: 93.393, 93.394, 93.395, and 93.399.

Where did a proposed CCOP Research Base have to be located?

Applicants proposing to be CCOP Research Bases had to be located either at an NCI-supported Clinical Cooperative Group or at an NCI-designated Cancer Center. This requirement reflected the expectation that Research Bases would already have the infrastructure and expertise needed to develop and oversee multicenter clinical trials.

Why was location at an NCI-supported Cooperative Group or NCI-designated Cancer Center required?

The FOA expected Research Bases to have established infrastructure and expertise for multicenter trial development and oversight, such as protocol development capacity, regulatory compliance, data management systems, statistical analysis support, and experience coordinating multiple participating sites. Locating the Research Base at an NCI-supported Cooperative Group or an NCI-designated Cancer Center was intended to ensure those capabilities were in place.

What funding mechanism was used for this opportunity?

This opportunity used the U10 cooperative agreement mechanism. A cooperative agreement is not a standard grant in which the awardee operates independently; it implies substantial scientific or programmatic involvement by NCI during the conduct of the funded activities.

Does the U10 cooperative agreement mean NCI would be involved during the project?

Yes. The U10 cooperative agreement mechanism indicates substantial scientific or programmatic involvement by NCI during the conduct of the funded activities.

Was this opportunity discretionary funding?

Yes. The announcement was categorized as discretionary funding.

Was cost sharing or matching required?

No. The FOA did not require cost sharing or matching funds.

What was the estimated total funding level for the announcement?

The estimated total funding level listed for the announcement was $42,600,000. This reflected the scale of infrastructure and network coordination expected for Research Bases supporting national community oncology trials.

What types of organizations were eligible to apply?

Eligibility included many types of U.S.-based institutions and organizations, including public and state-controlled institutions of higher education, private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), for-profit organizations other than small businesses, tribal governments and tribal organizations, faith-based and community-based organizations, and regional organizations. Several categories of minority-serving institutions were also included, such as HBCUs, Hispanic-serving institutions, Alaska Native and Native Hawaiian-serving institutions, and tribally controlled colleges and universities. Eligible federal agencies were also included as described in the FOA.

Were foreign organizations eligible to apply?

No. Foreign organizations were not eligible to apply.

Were foreign components of U.S. organizations allowed?

No. Foreign components of U.S. organizations were not allowed.

When was the FOA posted and when were applications due?

The FOA was posted and created on May 24, 2011. The original and final application due date was July 28, 2011.

What is the current status of this funding opportunity?

The opportunity was archived on August 28, 2011.

Where was the official full announcement made available?

The official full announcement was made available through the NIH Grants Guide (via the link provided in the source text).

Who was listed as a contact for technical access or linking issues?

NIH Office of Extramural Research (OER) webmaster contact information was included for technical access or linking issues.

What was the practical goal of funding CCOP Research Bases?

The practical goal was to fund entities that would originate and manage the clinical trial portfolio for the CCOP Network so that community oncologists could enroll patients onto NCI-approved studies that were centrally designed, coordinated, and analyzed by well-equipped Research Bases.

How did this program aim to impact patients receiving care in community clinics?

By enabling community oncologists and clinics to participate in NCI-approved trials, the program aimed to broaden access to cancer prevention, control, and treatment trials outside of large academic medical centers, helping bring research opportunities and leading-edge care options closer to where many patients already receive care.

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