Opportunity Information: Apply for RFA CA 10 011

  • The National Institutes of Health in the education health sector is offering a public funding opportunity titled "Community Clinical Oncology Program Research Bases (U10)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393 Cancer Cause and Prevention Research 93.394 Cancer Detection and Diagnosis Research 93.395 Cancer Treatment Research 93.396 Cancer Biology Research 93.399 Cancer Control.
  • This funding opportunity was created on Jul 16, 2010 and posted on Jul 16, 2010.
  • Applicants must submit their applications by Sep 16, 2010. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • The funding agency has allocated a total of $1,500,000.00 to eligible and selected applicants.
  • The number of recipients for this funding is limited to 1 candidate(s).
  • Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification) Public and State controlled institutions of higher education Private institutions of higher education Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education Native American tribal governments (Federally recognized) Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education For profit organizations other than small businesses Native American tribal organizations (other than Federally recognized tribal governments).
  • Other Eligible Applicants include the following Alaska Native and Native Hawaiian Serving Institutions Eligible Agencies of the Federal Government Faith based or Community based Organizations Hispanic serving Institutions Historically Black Colleges and Universities (HBCUs) Tribally Controlled Colleges and Universities (TCCUs) U.S. Territory or Possession.
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Opportunity Summary:

The Community Clinical Oncology Program Research Bases (U10) opportunity (RFA-CA-10-011) is a National Cancer Institute (NCI), NIH funding announcement inviting applications from qualified institutions to serve as a Research Base within the NCI-supported Community Clinical Oncology Program (CCOP) Network. The central aim of CCOP is to expand the reach and quality of cancer clinical research by developing and running state-of-the-art clinical trials in cancer prevention, cancer control, and cancer treatment, while ensuring meaningful participation by community oncologists and the patient populations they care for. In practical terms, this program is meant to move high-quality clinical trials beyond large academic hospitals and into community settings, so that more patients can access trials and the results better reflect real-world populations.

CCOP is structured as a network with three interconnected components, each covered by its own funding announcement: CCOP Groups (community-based oncologists and practices that enroll patients onto NCI-approved trials), Minority-Based CCOPs (similar groups operating in communities with a high proportion of minority patients, focusing on improving minority participation in trials), and CCOP Research Bases (the focus of this FOA). The Research Base role is the hub of trial creation and execution: Research Bases design and conduct the clinical trials, provide the operational leadership to run them across the network, manage and analyze the resulting data, and disseminate findings through reporting and publication. In other words, Groups and Minority-Based Groups are primarily responsible for accruing participants, while Research Bases are responsible for the scientific and operational backbone that makes those trials possible and ensures they are rigorously analyzed and reported.

A key structural requirement is that CCOP Research Bases must be located either at an NCI-supported Clinical Cooperative Group or at an NCI-designated Cancer Center. This reflects the expectation that applicants already have the scientific infrastructure, cooperative group relationships, regulatory experience, and data management capacity needed to develop multicenter trials and oversee high-quality execution. Because the CCOP network components are funded through parallel announcements, applicants for a Research Base are expected to understand how their responsibilities connect with the community-based enrolling sites. The announcement explicitly notes related FOAs for the other components: RFA-CA-10-010 for CCOP Groups and RFA-CA-10-012 for Minority-Based CCOP Groups, and emphasizes that Research Base applicants should familiarize themselves with those companion opportunities to align expectations, workflows, and network functioning.

Funding is provided through the NIH U10 cooperative agreement mechanism, meaning this is an assistance award with substantial federal scientific and/or programmatic involvement. Compared with a traditional grant, a cooperative agreement typically involves closer collaboration with NCI on program priorities, trial oversight, performance expectations, and coordination across the network. The NCI anticipated making one award under this specific solicitation, with up to $1.5 million in total costs committed in fiscal year 2011, indicating a single, competitively selected Research Base to carry out the required leadership, trial development, coordination, data operations, and reporting functions for the CCOP network activities covered by the award.

Eligibility is broad and includes many types of organizations, such as public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), Native American tribal governments and tribal organizations, and a variety of mission-focused institutions and community-based entities. The eligibility list explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, and U.S. territories or possessions. Despite the broad eligibility categories, applicants still must meet the specific program requirement that the Research Base be located at an NCI-supported Clinical Cooperative Group or an NCI-designated Cancer Center.

Administratively, the opportunity was posted July 16, 2010, with an original and current closing date of September 16, 2010, and an archive date of October 17, 2010. It is categorized as discretionary funding and aligns with NIH cancer-related CFDA listings spanning prevention, detection and diagnosis, treatment, biology, and control research (93.393, 93.394, 93.395, 93.396, 93.399). There is no cost sharing or matching requirement stated. The full announcement was made available through the NIH grants guide, with technical access support routed through the NIH Office of Extramural Research (OER) webmaster contacts.

Frequently Asked Questions (FAQs)

What is the CCOP Research Bases (U10) funding opportunity?

This opportunity (RFA-CA-10-011) is a National Cancer Institute (NCI), NIH funding announcement inviting applications from qualified institutions to serve as a Research Base within the NCI-supported Community Clinical Oncology Program (CCOP) Network.

What is the main goal of the Community Clinical Oncology Program (CCOP)?

The central aim of CCOP is to expand the reach and quality of cancer clinical research by developing and running state-of-the-art clinical trials in cancer prevention, cancer control, and cancer treatment, while ensuring meaningful participation by community oncologists and the patient populations they care for.

Why does CCOP emphasize community settings for clinical trials?

CCOP is designed to move high-quality clinical trials beyond large academic hospitals and into community settings so more patients can access trials and so trial results better reflect real-world patient populations.

What are the three main components of the CCOP network?

CCOP is structured as a network with three interconnected components: CCOP Groups, Minority-Based CCOPs, and CCOP Research Bases (the focus of this funding opportunity). Each component is covered by its own funding announcement.

What does a CCOP Research Base do?

The Research Base serves as the hub of trial creation and execution. Research Bases design and conduct clinical trials, provide operational leadership to run them across the network, manage and analyze resulting data, and disseminate findings through reporting and publication.

How do CCOP Groups and Minority-Based CCOP Groups differ from Research Bases?

CCOP Groups and Minority-Based CCOP Groups are primarily responsible for accruing (enrolling) participants onto NCI-approved trials. Research Bases provide the scientific and operational backbone that enables those trials to be developed, coordinated, analyzed, and reported.

Where must a CCOP Research Base be located?

A key requirement is that a CCOP Research Base must be located either at an NCI-supported Clinical Cooperative Group or at an NCI-designated Cancer Center.

Why is there a location requirement for Research Bases?

The location requirement reflects the expectation that applicants already have the scientific infrastructure, cooperative group relationships, regulatory experience, and data management capacity needed to develop multicenter trials and oversee high-quality execution.

What funding mechanism is used for this opportunity?

Funding is provided through the NIH U10 cooperative agreement mechanism.

What does it mean that this is a U10 cooperative agreement?

A cooperative agreement is an assistance award with substantial federal scientific and/or programmatic involvement. Compared with a traditional grant, it typically involves closer collaboration with NCI on program priorities, trial oversight, performance expectations, and coordination across the network.

How many awards did NCI anticipate making under this solicitation?

NCI anticipated making one award under this specific solicitation.

What level of funding was anticipated?

Up to $1.5 million in total costs was committed in fiscal year 2011 for this solicitation.

Is cost sharing or matching required?

No cost sharing or matching requirement is stated in the information provided.

Who is eligible to apply?

Eligibility is broad and includes many types of organizations such as public and private institutions of higher education, nonprofit organizations (with or without 501(c)(3) status), for-profit organizations (other than small businesses), Native American tribal governments and tribal organizations, and a variety of mission-focused institutions and community-based entities.

Are minority-serving institutions included in the eligible applicant types?

Yes. The eligibility list explicitly includes Alaska Native and Native Hawaiian Serving Institutions, Hispanic-Serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and other community-based entities.

Are faith-based or community-based organizations eligible?

Yes. Faith-based or community-based organizations are explicitly included in the eligibility list.

Are U.S. territories or possessions eligible to apply?

Yes. U.S. territories or possessions are included among eligible entities.

Does broad eligibility remove the need to meet the Research Base location requirement?

No. Despite the broad eligibility categories, applicants still must meet the specific program requirement that the Research Base be located at an NCI-supported Clinical Cooperative Group or an NCI-designated Cancer Center.

Are there related funding announcements for the other CCOP components?

Yes. Related FOAs are noted for the other components: RFA-CA-10-010 for CCOP Groups and RFA-CA-10-012 for Minority-Based CCOP Groups.

Why should Research Base applicants review the companion CCOP funding announcements?

Because the CCOP network components are funded through parallel announcements, Research Base applicants are expected to understand how their responsibilities connect with community-based enrolling sites and to align expectations, workflows, and network functioning.

When was this opportunity posted and when did it close?

The opportunity was posted on July 16, 2010. The original and current closing date was September 16, 2010.

When was this announcement archived?

The archive date listed is October 17, 2010.

How is this funding opportunity categorized?

It is categorized as discretionary funding.

Which CFDA program areas are associated with this announcement?

It aligns with NIH cancer-related CFDA listings spanning prevention, detection and diagnosis, treatment, biology, and control research: 93.393, 93.394, 93.395, 93.396, and 93.399.

Where was the full announcement made available?

The full announcement was made available through the NIH grants guide.

Where is technical access support directed?

Technical access support is routed through the NIH Office of Extramural Research (OER) webmaster contacts.

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